Endogenous and Exogenous Opioids in Pain
Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose. These compounds act on the endogenous opioid system, which comprises four G protein-coupled receptors (mu, delta, kappa, a...
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| Veröffentlicht in: | Annual review of neuroscience 2018-07, Vol.41 (1), p.453-473 |
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| container_title | Annual review of neuroscience |
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| creator | Corder, Gregory Castro, Daniel C Bruchas, Michael R Scherrer, Grégory |
| description | Opioids are the most commonly used and effective analgesic treatments for severe pain, but they have recently come under scrutiny owing to epidemic levels of abuse and overdose. These compounds act on the endogenous opioid system, which comprises four G protein-coupled receptors (mu, delta, kappa, and nociceptin) and four major peptide families (β-endorphin, enkephalins, dynorphins, and nociceptin orphanin FQ). In this review, we first describe the functional organization and pharmacology of the endogenous opioid system. We then summarize current knowledge on the signaling mechanisms by which opioids regulate neuronal function and neurotransmission. Finally, we discuss the loci of opioid analgesic action along peripheral and central pain pathways, emphasizing the pain-relieving properties of opioids against the affective dimension of the pain experience. |
| doi_str_mv | 10.1146/annurev-neuro-080317-061522 |
| format | Article |
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These compounds act on the endogenous opioid system, which comprises four G protein-coupled receptors (mu, delta, kappa, and nociceptin) and four major peptide families (β-endorphin, enkephalins, dynorphins, and nociceptin orphanin FQ). In this review, we first describe the functional organization and pharmacology of the endogenous opioid system. We then summarize current knowledge on the signaling mechanisms by which opioids regulate neuronal function and neurotransmission. 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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Abuse analgesia Analgesics Analgesics, Opioid - metabolism Analgesics, Opioid - therapeutic use Animals Enkephalins Functional morphology Humans Narcotics neuroanatomy Neurotransmission Nociceptin opioid Opioid receptors Overdose Pain Pain - drug therapy Pain - metabolism Pain Perception perception Perceptions Receptors, G-Protein-Coupled - metabolism Signaling |
| title | Endogenous and Exogenous Opioids in Pain |
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