Macrophage-dependent impairment of a^sub 2^-adrenergic autoreceptor inhibition of Ca^sup 2+^ channels in sympathetic neurons from DOCA-salt but not high-fat diet-induced hypertensive rats

DOCA-salt and obesity-related hypertension are associated with inflammation and sympathetic nervous system hyperactivity. Prejunctional α2-adrenergic receptors (α2ARs) provide negative feedback to norepinephrine release from sympathetic nerves through inhibition of N-type Ca2+ channels. Increased ne...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2018-04, Vol.314 (4), p.H863
Hauptverfasser:	Mui, Ryan K, Fernandes, Roxanne N, Garver, Hannah G, Rooijen, Nico Van, Galligan, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Arteries Bisphosphonates Blood pressure Calcium channels Calcium channels (N-type) Calcium ions Cell culture Channels Clodronic acid Desensitization Diet Ganglia High fat diet Hyperactivity Hypertension Inhibition Innervation Internalization Ions Macrophages Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes mRNA Negative feedback Nerves Neurons Neurotransmitters Norepinephrine Obesity Oxidative stress Proteins Rats Receptors Receptors (physiology) Rodents Salts Signaling Sympathetic nerves Sympathetic nervous system
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