Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI

Acetaminophen (APAP) is one of the most intensively studied compounds that causes hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal information on the distribution of APAP, its metabolites and GSH adducts in the liver tissue is not yet available. Here, we addres...

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Veröffentlicht in:	Archives of toxicology 2018-09, Vol.92 (9), p.2963-2977
Hauptverfasser:	Sezgin, Selahaddin, Hassan, Reham, Zühlke, Sebastian, Kuepfer, Lars, Hengstler, Jan G., Spiteller, Michael, Ghallab, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Adducts Analgesics Biomedical and Life Sciences Biomedicine Depletion Desorption Environmental Health Hepatotoxicity Intoxication Ionization Ions Liver Mass spectrometry Mass spectroscopy Metabolites Occupational Medicine/Industrial Medicine Organ Toxicity and Mechanisms Pharmacology/Toxicology Sulfates Time dependent analysis
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