Enhancing Analytical Separations Using Super-Resolution Microscopy

Enhancing Analytical Separations Using Super-Resolution Microscopy

Super-resolution microscopy is becoming an invaluable tool to investigate structure and dynamics driving protein interactions at interfaces. In this review, we highlight the applications of super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and s...

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Veröffentlicht in:Annual review of physical chemistry 2018-04, Vol.69 (1), p.353-375
Hauptverfasser: Moringo, Nicholas A, Shen, Hao, Bishop, Logan D.C, Wang, Wenxiao, Landes, Christy F
Format: Artikel
Sprache:eng
Schlagworte:
Adsorption
Chromatography
Desorption
Dynamic structural analysis
industrial drug purification
Microscopy
Organic chemistry
Proteins
single-molecule spectroscopy
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container_issue 1
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container_title Annual review of physical chemistry
container_volume 69
creator Moringo, Nicholas A
Shen, Hao
Bishop, Logan D.C
Wang, Wenxiao
Landes, Christy F
description Super-resolution microscopy is becoming an invaluable tool to investigate structure and dynamics driving protein interactions at interfaces. In this review, we highlight the applications of super-resolution microscopy for quantifying the physics and chemistry that occur between target proteins and stationary-phase supports during chromatographic separations. Our discussion concentrates on the newfound ability of super-resolved single-protein spectroscopy to inform theoretical parameters via quantification of adsorption-desorption dynamics, protein unfolding, and nanoconfined transport.
doi_str_mv 10.1146/annurev-physchem-052516-045018
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subjects Adsorption
Chromatography
Desorption
Dynamic structural analysis
industrial drug purification
Microscopy
Organic chemistry
Proteins
single-molecule spectroscopy
title Enhancing Analytical Separations Using Super-Resolution Microscopy
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