Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats
Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (2...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2018-07, Vol.32 (7), p.e22162-n/a |
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| creator | Zaky, Hanan S. Gad, Amany M. Nemr, Ekram Hassan, Wedad Abd El‐Raouf, Ola M. Ali, Aza A. |
| description | Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C. longa, N. sativa, or both, respectively, 1 h before the administration of both the drugs for 21 days. SV and/or paracetamol significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, relative liver/body weight ratio, malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐α), and caspase‐3 (Casp‐3) while significantly decreased albumin, total protein, glutathione (GSH) reduced, GSH peroxidase, and superoxide dismutase (SOD). Preadministration of C. longa and/or N. sativa caused protective effect against the hepatotoxicity induced by both drugs. |
| doi_str_mv | 10.1002/jbt.22162 |
| format | Article |
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Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C. longa, N. sativa, or both, respectively, 1 h before the administration of both the drugs for 21 days. SV and/or paracetamol significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, relative liver/body weight ratio, malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐α), and caspase‐3 (Casp‐3) while significantly decreased albumin, total protein, glutathione (GSH) reduced, GSH peroxidase, and superoxide dismutase (SOD). Preadministration of C. longa and/or N. sativa caused protective effect against the hepatotoxicity induced by both drugs.</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.22162</identifier><identifier>PMID: 29799656</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alanine ; Alanine transaminase ; Alkaline phosphatase ; Analgesics ; Aspartate aminotransferase ; Bilirubin ; Body weight ; Caspase ; Curcuma longa ; Drugs ; Fuel consumption ; Glutathione ; Hepatotoxicity ; Liver ; Malondialdehyde ; Natural products ; Nigella sativa ; Paracetamol ; Peroxidase ; Proteins ; Rats ; Rodents ; Sodium ; Sodium valproate ; Superoxide dismutase ; Toxicity ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Valproic acid</subject><ispartof>Journal of biochemical and molecular toxicology, 2018-07, Vol.32 (7), p.e22162-n/a</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3792-8c640e8e971e9704e99e3cde309f833d7062848a577a67d14e074ce03d018b393</citedby><cites>FETCH-LOGICAL-c3792-8c640e8e971e9704e99e3cde309f833d7062848a577a67d14e074ce03d018b393</cites><orcidid>0000-0002-6175-184X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.22162$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.22162$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29799656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaky, Hanan S.</creatorcontrib><creatorcontrib>Gad, Amany M.</creatorcontrib><creatorcontrib>Nemr, Ekram</creatorcontrib><creatorcontrib>Hassan, Wedad</creatorcontrib><creatorcontrib>Abd El‐Raouf, Ola M.</creatorcontrib><creatorcontrib>Ali, Aza A.</creatorcontrib><title>Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J Biochem Mol Toxicol</addtitle><description>Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C. longa, N. sativa, or both, respectively, 1 h before the administration of both the drugs for 21 days. SV and/or paracetamol significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, relative liver/body weight ratio, malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐α), and caspase‐3 (Casp‐3) while significantly decreased albumin, total protein, glutathione (GSH) reduced, GSH peroxidase, and superoxide dismutase (SOD). Preadministration of C. longa and/or N. sativa caused protective effect against the hepatotoxicity induced by both drugs.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alkaline phosphatase</subject><subject>Analgesics</subject><subject>Aspartate aminotransferase</subject><subject>Bilirubin</subject><subject>Body weight</subject><subject>Caspase</subject><subject>Curcuma longa</subject><subject>Drugs</subject><subject>Fuel consumption</subject><subject>Glutathione</subject><subject>Hepatotoxicity</subject><subject>Liver</subject><subject>Malondialdehyde</subject><subject>Natural products</subject><subject>Nigella sativa</subject><subject>Paracetamol</subject><subject>Peroxidase</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Sodium valproate</subject><subject>Superoxide dismutase</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Valproic acid</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kL1u2zAURomgQeykHfoCBYFOGWRfUhIpjm2QXzjo4s4CRV6hMiTRJak22vroYewkWweCBO75ziU-Qj4zWDEAvt41ccU5E_yELBkolUEh2IfDu8yEkLAg5yHsAKBUsjwjC66kUqIUS_Lv0dmp19H5mWLboomBupYGNyAddZy87uneJ-YwGOkv3Cc4uqfOdHGm3ZgmaGkzU-OGpkuRLlEHg-2mgf7RfYrriFSPlu611wajHlyfotTrGD6S01b3AT-93hfk58319uou2_y4vb_6tslMLhXPKiMKwAqVZOlAgUphbizmoNoqz60Ewaui0qWUWkjLCgRZGITcAquaXOUX5OvRm77ze8IQ652b_JhW1hwk55Us5Qt1eaSMdyF4bOu97wbt55pB_dJ1nbquD10n9surcWoGtO_kW7kJWB-Bv12P8_9N9cP37VH5DELsiiU</recordid><startdate>201807</startdate><enddate>201807</enddate><creator>Zaky, Hanan S.</creator><creator>Gad, Amany M.</creator><creator>Nemr, Ekram</creator><creator>Hassan, Wedad</creator><creator>Abd El‐Raouf, Ola M.</creator><creator>Ali, Aza A.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-6175-184X</orcidid></search><sort><creationdate>201807</creationdate><title>Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats</title><author>Zaky, Hanan S. ; Gad, Amany M. ; Nemr, Ekram ; Hassan, Wedad ; Abd El‐Raouf, Ola M. ; Ali, Aza A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3792-8c640e8e971e9704e99e3cde309f833d7062848a577a67d14e074ce03d018b393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alkaline phosphatase</topic><topic>Analgesics</topic><topic>Aspartate aminotransferase</topic><topic>Bilirubin</topic><topic>Body weight</topic><topic>Caspase</topic><topic>Curcuma longa</topic><topic>Drugs</topic><topic>Fuel consumption</topic><topic>Glutathione</topic><topic>Hepatotoxicity</topic><topic>Liver</topic><topic>Malondialdehyde</topic><topic>Natural products</topic><topic>Nigella sativa</topic><topic>Paracetamol</topic><topic>Peroxidase</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Sodium valproate</topic><topic>Superoxide dismutase</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Valproic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaky, Hanan S.</creatorcontrib><creatorcontrib>Gad, Amany M.</creatorcontrib><creatorcontrib>Nemr, Ekram</creatorcontrib><creatorcontrib>Hassan, Wedad</creatorcontrib><creatorcontrib>Abd El‐Raouf, Ola M.</creatorcontrib><creatorcontrib>Ali, Aza A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaky, Hanan S.</au><au>Gad, Amany M.</au><au>Nemr, Ekram</au><au>Hassan, Wedad</au><au>Abd El‐Raouf, Ola M.</au><au>Ali, Aza A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J Biochem Mol Toxicol</addtitle><date>2018-07</date><risdate>2018</risdate><volume>32</volume><issue>7</issue><spage>e22162</spage><epage>n/a</epage><pages>e22162-n/a</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>Possible hepatoprotective effect of Curcuma longa and/or Nigella sativa against hepatotoxicity induced by coadministration of sodium valproate (SV) and paracetamol was studied. Rats were divided into 10 groups, control groups 1, 2, 3, and 4 received vehicles, C. longa (200 mg/kg, p.o.), N. sativa (250 mg/kg, p.o.), or both herbs for 21 days, respectively. Toxicity groups 5, 6, and 7 received SV (300 mg/kg, i.p.), paracetamol (1000 mg/kg, p.o.) for the last 4 days or both for 21 days, respectively. Protection groups 8, 9, and 10 received C. longa, N. sativa, or both, respectively, 1 h before the administration of both the drugs for 21 days. SV and/or paracetamol significantly increased aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, relative liver/body weight ratio, malondialdehyde (MDA), tumor necrosis factor alpha (TNF‐α), and caspase‐3 (Casp‐3) while significantly decreased albumin, total protein, glutathione (GSH) reduced, GSH peroxidase, and superoxide dismutase (SOD). Preadministration of C. longa and/or N. sativa caused protective effect against the hepatotoxicity induced by both drugs.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29799656</pmid><doi>10.1002/jbt.22162</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6175-184X</orcidid></addata></record> |
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| subjects | Alanine Alanine transaminase Alkaline phosphatase Analgesics Aspartate aminotransferase Bilirubin Body weight Caspase Curcuma longa Drugs Fuel consumption Glutathione Hepatotoxicity Liver Malondialdehyde Natural products Nigella sativa Paracetamol Peroxidase Proteins Rats Rodents Sodium Sodium valproate Superoxide dismutase Toxicity Tumor necrosis factor-TNF Tumor necrosis factor-α Valproic acid |
| title | Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats |
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