Drug‐induced Proarrhythmia and Torsade de Pointes: A Primer for Students and Practitioners of Medicine and Pharmacy

Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety‐rela...

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Veröffentlicht in:	Journal of clinical pharmacology 2018-08, Vol.58 (8), p.997-1012
Hauptverfasser:	Turner, J. Rick, Rodriguez, Ignacio, Mantovani, Emily, Gintant, Gary, Kowey, Peter R., Klotzbaugh, Ralph J., Prasad, Krishna, Sager, Philip T., Stockbridge, Norman, Strnadova, Colette
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmia comprehensive in vitro proarrhythmia assay concentration‐response modeling Drug development Electrocardiography Human behavior Liability Pharmacy Proarrhythmic cardiac safety Prolongation Public health Regulatory agencies therapeutic use of QTc‐prolonging drugs thorough QT/QTc study Ventricle
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