Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system

Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cel...

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Veröffentlicht in:The Lancet (British edition) 2000-10, Vol.356 (9240), p.1493-1494
Hauptverfasser: Slobod, Karen S, Taylor, Gregory H, Sandlund, John T, Furth, Priscilla, Helton, Kathleen J, Sixbey, John W
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container_end_page 1494
container_issue 9240
container_start_page 1493
container_title The Lancet (British edition)
container_volume 356
creator Slobod, Karen S
Taylor, Gregory H
Sandlund, John T
Furth, Priscilla
Helton, Kathleen J
Sixbey, John W
description Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.
doi_str_mv 10.1016/S0140-6736(00)02879-8
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Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(00)02879-8</identifier><identifier>PMID: 11081539</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adolescent ; Adult ; AIDS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral agents ; Antiviral agents ; Biological and medical sciences ; Brain - drug effects ; Brain - pathology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - virology ; Central nervous system ; Chemotherapy ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Drug resistance ; Drug therapy ; Edema ; Epstein-Barr virus ; Epstein-Barr Virus Infections - drug therapy ; Epstein-Barr Virus Infections - virology ; Female ; Herpesvirus 4, Human - drug effects ; HIV ; Human immunodeficiency virus ; Humans ; Hydroxyurea ; Hydroxyurea - therapeutic use ; Irradiation ; Lesions ; Lymphocytes ; Lymphoma ; Lymphoma, AIDS-Related - drug therapy ; Lymphoma, AIDS-Related - virology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system ; NMR ; Nuclear magnetic resonance ; Patients ; Pharmacology. 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subjects Acquired immune deficiency syndrome
Adolescent
Adult
AIDS
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral agents
Antiviral agents
Biological and medical sciences
Brain - drug effects
Brain - pathology
Brain Neoplasms - drug therapy
Brain Neoplasms - virology
Central nervous system
Chemotherapy
Cytotoxicity
Deoxyribonucleic acid
DNA
Drug dosages
Drug resistance
Drug therapy
Edema
Epstein-Barr virus
Epstein-Barr Virus Infections - drug therapy
Epstein-Barr Virus Infections - virology
Female
Herpesvirus 4, Human - drug effects
HIV
Human immunodeficiency virus
Humans
Hydroxyurea
Hydroxyurea - therapeutic use
Irradiation
Lesions
Lymphocytes
Lymphoma
Lymphoma, AIDS-Related - drug therapy
Lymphoma, AIDS-Related - virology
Magnetic Resonance Imaging
Male
Medical sciences
Nervous system
NMR
Nuclear magnetic resonance
Patients
Pharmacology. Drug treatments
Toxoplasmosis
Viruses
title Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system
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