Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system
Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cel...
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| Veröffentlicht in: | The Lancet (British edition) 2000-10, Vol.356 (9240), p.1493-1494 |
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| container_issue | 9240 |
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| creator | Slobod, Karen S Taylor, Gregory H Sandlund, John T Furth, Priscilla Helton, Kathleen J Sixbey, John W |
| description | Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers. |
| doi_str_mv | 10.1016/S0140-6736(00)02879-8 |
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Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(00)02879-8</identifier><identifier>PMID: 11081539</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Adolescent ; Adult ; AIDS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral agents ; Antiviral agents ; Biological and medical sciences ; Brain - drug effects ; Brain - pathology ; Brain Neoplasms - drug therapy ; Brain Neoplasms - virology ; Central nervous system ; Chemotherapy ; Cytotoxicity ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Drug resistance ; Drug therapy ; Edema ; Epstein-Barr virus ; Epstein-Barr Virus Infections - drug therapy ; Epstein-Barr Virus Infections - virology ; Female ; Herpesvirus 4, Human - drug effects ; HIV ; Human immunodeficiency virus ; Humans ; Hydroxyurea ; Hydroxyurea - therapeutic use ; Irradiation ; Lesions ; Lymphocytes ; Lymphoma ; Lymphoma, AIDS-Related - drug therapy ; Lymphoma, AIDS-Related - virology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system ; NMR ; Nuclear magnetic resonance ; Patients ; Pharmacology. 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Oct 28, 2000</rights><rights>Copyright Elsevier Limited Oct 28, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-2e910421351dafaf2e0a71ba029203aae34a6fa2eabc4bde8f6a1e368675786d3</citedby><cites>FETCH-LOGICAL-c509t-2e910421351dafaf2e0a71ba029203aae34a6fa2eabc4bde8f6a1e368675786d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199064961?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002,64392,64396,72476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1514864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11081539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slobod, Karen S</creatorcontrib><creatorcontrib>Taylor, Gregory H</creatorcontrib><creatorcontrib>Sandlund, John T</creatorcontrib><creatorcontrib>Furth, Priscilla</creatorcontrib><creatorcontrib>Helton, Kathleen J</creatorcontrib><creatorcontrib>Sixbey, John W</creatorcontrib><title>Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - virology</subject><subject>Central nervous system</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Drug resistance</subject><subject>Drug therapy</subject><subject>Edema</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - drug therapy</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Female</subject><subject>Herpesvirus 4, Human - drug effects</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Hydroxyurea</subject><subject>Hydroxyurea - therapeutic use</subject><subject>Irradiation</subject><subject>Lesions</subject><subject>Lymphocytes</subject><subject>Lymphoma</subject><subject>Lymphoma, AIDS-Related - drug therapy</subject><subject>Lymphoma, AIDS-Related - virology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Pharmacology. 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Antiparasitic agents</topic><topic>Antiretroviral agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - virology</topic><topic>Central nervous system</topic><topic>Chemotherapy</topic><topic>Cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Drug resistance</topic><topic>Drug therapy</topic><topic>Edema</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - drug therapy</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Female</topic><topic>Herpesvirus 4, Human - drug effects</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Hydroxyurea</topic><topic>Hydroxyurea - therapeutic use</topic><topic>Irradiation</topic><topic>Lesions</topic><topic>Lymphocytes</topic><topic>Lymphoma</topic><topic>Lymphoma, AIDS-Related - drug therapy</topic><topic>Lymphoma, AIDS-Related - virology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Pharmacology. 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system</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2000-10-28</date><risdate>2000</risdate><volume>356</volume><issue>9240</issue><spage>1493</spage><epage>1494</epage><pages>1493-1494</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Epstein-Barr virus (EBV) targeted therapeutic strategies for viral associated malignant diseases have received only perfunctory consideration, first, because latent herpesviruses have been intractable to antiviral chemotherapy and, second, because the role EBV has in maintenance of the malignant cell phenotype has been uncertain. Two patients with EBV related primary central nervous system lymphoma (PCNSL) in the setting of advanced AIDS, were treated with low dose hydroxyurea based on in vitro anti-EBV activity. The responses obtained here suggest the promise of antiviral approaches in select cancers.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11081539</pmid><doi>10.1016/S0140-6736(00)02879-8</doi><tpages>2</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome Adolescent Adult AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral agents Antiviral agents Biological and medical sciences Brain - drug effects Brain - pathology Brain Neoplasms - drug therapy Brain Neoplasms - virology Central nervous system Chemotherapy Cytotoxicity Deoxyribonucleic acid DNA Drug dosages Drug resistance Drug therapy Edema Epstein-Barr virus Epstein-Barr Virus Infections - drug therapy Epstein-Barr Virus Infections - virology Female Herpesvirus 4, Human - drug effects HIV Human immunodeficiency virus Humans Hydroxyurea Hydroxyurea - therapeutic use Irradiation Lesions Lymphocytes Lymphoma Lymphoma, AIDS-Related - drug therapy Lymphoma, AIDS-Related - virology Magnetic Resonance Imaging Male Medical sciences Nervous system NMR Nuclear magnetic resonance Patients Pharmacology. Drug treatments Toxoplasmosis Viruses |
| title | Epstein-Barr virus-targeted therapy for AIDS-related primary lymphoma of the central nervous system |
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