Intrahepatic hepatitis B virus large surface antigen induces hepatocyte hyperploidy via failure of cytokinesis

Hepatitis B virus (HBV) is an aetiological factor for liver cirrhosis and hepatocellular carcinoma (HCC). Despite current antiviral therapies that successfully reduce the viral load in patients with chronic hepatitis B, persistent hepatitis B surface antigen (HBsAg) remains a risk factor for HCC. To...

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Veröffentlicht in:	The Journal of pathology 2018-08, Vol.245 (4), p.502-513
Hauptverfasser:	Li, Tian‐Neng, Wu, Yi‐Ju, Tsai, Hung‐Wen, Sun, Cheng‐Pu, Wu, Yi‐Hsuan, Wu, Hui‐Lin, Pei, Yi‐Ning, Lu, Kuan‐Ying, Yen, Tim Ting‐Chung, Chang, Chien‐Wen, Chan, Hong‐Lin, Tao, Mi‐Hua, Liou, Jun‐Yang, Chang, Margaret Dah‐Tsyr, Su, Ih‐Jen, Wang, Lily Hui‐Ching
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antiviral agents Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - virology Cell Cycle Proteins - metabolism Cell Transformation, Viral Chromatin Cirrhosis Cytokinesis Deoxyribonucleic acid Disease Models, Animal DNA DNA Damage G2 Phase Cell Cycle Checkpoints G2/M checkpoint ground‐glass hepatocytes Hep G2 Cells Hepatitis Hepatitis B surface antigen Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - metabolism Hepatitis B virus - genetics Hepatitis B virus - metabolism Hepatitis B Virus, Woodchuck - genetics Hepatitis B Virus, Woodchuck - metabolism Hepatitis B, Chronic - genetics Hepatitis B, Chronic - metabolism Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Hepatocellular carcinoma Hepatocytes Hepatocytes - metabolism Hepatocytes - pathology Hepatocytes - transplantation Hepatocytes - virology Host-Pathogen Interactions Humans Interferon LHBS Liver Liver cancer Liver cirrhosis Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - virology Marmota Mice, Transgenic Ploidies Polo-Like Kinase 1 polyploidy Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Risk factors Viruses
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