Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate

The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiog...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2018-08, Vol.123 (2), p.161-173
Hauptverfasser:	Tikkakoski, Antti J., Kangas, Pauliina, Suojanen, Lauri, Tahvanainen, Anna M., Eräranta, Arttu, Kähönen, Mika A.P., Sipilä, Kalle, Mustonen, Jukka T., Pörsti, Ilkka H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Administration, Sublingual Adrenergic beta-2 Receptor Agonists - pharmacology Adrenergic beta-2 Receptor Agonists - therapeutic use Adult Aged Albuterol - pharmacology Albuterol - therapeutic use Augmentation Blood pressure Blood Pressure - drug effects Body mass Body mass index Body size Cardiography Cardiography, Impedance Ejection Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female Heart rate Heart Rate - drug effects Hemodynamics Humans Hypertension - drug therapy Inhalation Male Middle Aged Multivariate analysis Nitroglycerin Nitroglycerin - pharmacology Nitroglycerin - therapeutic use Prospective Studies Respiration Salbutamol Treatment Outcome Vascular Resistance - drug effects Vascular Stiffness - drug effects Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Wave analysis Young Adult
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