Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate
The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiog...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2018-08, Vol.123 (2), p.161-173 |
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| creator | Tikkakoski, Antti J. Kangas, Pauliina Suojanen, Lauri Tahvanainen, Anna M. Eräranta, Arttu Kähönen, Mika A.P. Sipilä, Kalle Mustonen, Jukka T. Pörsti, Ilkka H. |
| description | The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiography and continuous pulse wave analysis from tonometric radial blood pressure. All subjects (n = 335, mean age 46, body mass index 26, 48% men) were without medications with cardiovascular influences. The effects of salbutamol inhalation (0.4 mg) versus the endothelium‐independent agent nitroglycerin resoriblet (0.25 mg) were examined during passive head‐up tilt, as the haemodynamic influences of these compounds depend on body position. Salbutamol decreased augmentation index by ~3‐4% units in supine and upright positions. Although salbutamol moderately increased cardiac index (+4.5%) and decreased systemic vascular resistance (−8.5%), the significant haemodynamic explanatory factors for decreased augmentation index in multivariate analysis were increased supine heart rate, and increased upright heart rate and decreased ejection duration (p |
| doi_str_mv | 10.1111/bcpt.12988 |
| format | Article |
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We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiography and continuous pulse wave analysis from tonometric radial blood pressure. All subjects (n = 335, mean age 46, body mass index 26, 48% men) were without medications with cardiovascular influences. The effects of salbutamol inhalation (0.4 mg) versus the endothelium‐independent agent nitroglycerin resoriblet (0.25 mg) were examined during passive head‐up tilt, as the haemodynamic influences of these compounds depend on body position. Salbutamol decreased augmentation index by ~3‐4% units in supine and upright positions. Although salbutamol moderately increased cardiac index (+4.5%) and decreased systemic vascular resistance (−8.5%), the significant haemodynamic explanatory factors for decreased augmentation index in multivariate analysis were increased supine heart rate, and increased upright heart rate and decreased ejection duration (p < 0.001 for all, r2 = 0.36–0.37). Sublingual nitroglycerin decreased supine and upright augmentation index by ~15% units and ~23% units, respectively. The haemodynamic explanatory factors for these changes in multivariate analysis were increased heart rate, reduced ejection duration and reduced systemic vascular resistance (p ≤ 0.021 for all, r2 = 0.22–0.34). In conclusion, the lowering influence of salbutamol on augmentation index may be largely explained by increased heart rate, suggesting that this effect may not predominantly reflect endothelial function.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12988</identifier><identifier>PMID: 29476697</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Administration, Inhalation ; Administration, Sublingual ; Adrenergic beta-2 Receptor Agonists - pharmacology ; Adrenergic beta-2 Receptor Agonists - therapeutic use ; Adult ; Aged ; Albuterol - pharmacology ; Albuterol - therapeutic use ; Augmentation ; Blood pressure ; Blood Pressure - drug effects ; Body mass ; Body mass index ; Body size ; Cardiography ; Cardiography, Impedance ; Ejection ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; Female ; Heart rate ; Heart Rate - drug effects ; Hemodynamics ; Humans ; Hypertension - drug therapy ; Inhalation ; Male ; Middle Aged ; Multivariate analysis ; Nitroglycerin ; Nitroglycerin - pharmacology ; Nitroglycerin - therapeutic use ; Prospective Studies ; Respiration ; Salbutamol ; Treatment Outcome ; Vascular Resistance - drug effects ; Vascular Stiffness - drug effects ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use ; Wave analysis ; Young Adult</subject><ispartof>Basic & clinical pharmacology & toxicology, 2018-08, Vol.123 (2), p.161-173</ispartof><rights>2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)</rights><rights>2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).</rights><rights>Copyright © 2018 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3938-958dfdfa89826ce9715a5b4215ce669304b077f64a5662739ee4bf2517aa721b3</citedby><cites>FETCH-LOGICAL-c3938-958dfdfa89826ce9715a5b4215ce669304b077f64a5662739ee4bf2517aa721b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.12988$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.12988$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29476697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tikkakoski, Antti J.</creatorcontrib><creatorcontrib>Kangas, Pauliina</creatorcontrib><creatorcontrib>Suojanen, Lauri</creatorcontrib><creatorcontrib>Tahvanainen, Anna M.</creatorcontrib><creatorcontrib>Eräranta, Arttu</creatorcontrib><creatorcontrib>Kähönen, Mika A.P.</creatorcontrib><creatorcontrib>Sipilä, Kalle</creatorcontrib><creatorcontrib>Mustonen, Jukka T.</creatorcontrib><creatorcontrib>Pörsti, Ilkka H.</creatorcontrib><title>Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiography and continuous pulse wave analysis from tonometric radial blood pressure. All subjects (n = 335, mean age 46, body mass index 26, 48% men) were without medications with cardiovascular influences. The effects of salbutamol inhalation (0.4 mg) versus the endothelium‐independent agent nitroglycerin resoriblet (0.25 mg) were examined during passive head‐up tilt, as the haemodynamic influences of these compounds depend on body position. Salbutamol decreased augmentation index by ~3‐4% units in supine and upright positions. Although salbutamol moderately increased cardiac index (+4.5%) and decreased systemic vascular resistance (−8.5%), the significant haemodynamic explanatory factors for decreased augmentation index in multivariate analysis were increased supine heart rate, and increased upright heart rate and decreased ejection duration (p < 0.001 for all, r2 = 0.36–0.37). Sublingual nitroglycerin decreased supine and upright augmentation index by ~15% units and ~23% units, respectively. The haemodynamic explanatory factors for these changes in multivariate analysis were increased heart rate, reduced ejection duration and reduced systemic vascular resistance (p ≤ 0.021 for all, r2 = 0.22–0.34). In conclusion, the lowering influence of salbutamol on augmentation index may be largely explained by increased heart rate, suggesting that this effect may not predominantly reflect endothelial function.</description><subject>Administration, Inhalation</subject><subject>Administration, Sublingual</subject><subject>Adrenergic beta-2 Receptor Agonists - pharmacology</subject><subject>Adrenergic beta-2 Receptor Agonists - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Albuterol - pharmacology</subject><subject>Albuterol - therapeutic use</subject><subject>Augmentation</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cardiography</subject><subject>Cardiography, Impedance</subject><subject>Ejection</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Heart rate</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Inhalation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nitroglycerin</subject><subject>Nitroglycerin - pharmacology</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Prospective Studies</subject><subject>Respiration</subject><subject>Salbutamol</subject><subject>Treatment Outcome</subject><subject>Vascular Resistance - drug effects</subject><subject>Vascular Stiffness - drug effects</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Wave analysis</subject><subject>Young Adult</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90LtOwzAUBmALgSgUFh4AWWJDSrEdx07GUi6tVImqlDlykhNIlUuxHUE3HoFn5ElwSSkbXo6Hz_-xfoTOKBlQd66SdGUHlEVhuIeOqOTMkyH393d3P-ihY2OWhDDJKTlEPRZxKUQkjxA8qjJpraqa8uvjs6izNoUM30CqQRnARY2H7XMFtVW2aGo8qTN4x4XBcyiVddI22L4AnimtyhJKB_5ejkFpi-fOnaCDXJUGTrezj57ubhejsTd9uJ-MhlMv9SM_9KIgzPIsV2EUMpFCJGmggoQzGqTgvusTnhApc8FVIASTfgTAk5wFVColGU38Prrocle6eW3B2HjZtLp2K2NGhAwlpUI4ddmpVDfGaMjjlS4qpdcxJfGm0XjTaPzTqMPn28g2qSDb0d8KHaAdeCtKWP8TFV-PZosu9BtFSYEb</recordid><startdate>201808</startdate><enddate>201808</enddate><creator>Tikkakoski, Antti J.</creator><creator>Kangas, Pauliina</creator><creator>Suojanen, Lauri</creator><creator>Tahvanainen, Anna M.</creator><creator>Eräranta, Arttu</creator><creator>Kähönen, Mika A.P.</creator><creator>Sipilä, Kalle</creator><creator>Mustonen, Jukka T.</creator><creator>Pörsti, Ilkka H.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201808</creationdate><title>Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate</title><author>Tikkakoski, Antti J. ; Kangas, Pauliina ; Suojanen, Lauri ; Tahvanainen, Anna M. ; Eräranta, Arttu ; Kähönen, Mika A.P. ; Sipilä, Kalle ; Mustonen, Jukka T. ; Pörsti, Ilkka H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3938-958dfdfa89826ce9715a5b4215ce669304b077f64a5662739ee4bf2517aa721b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Inhalation</topic><topic>Administration, Sublingual</topic><topic>Adrenergic beta-2 Receptor Agonists - pharmacology</topic><topic>Adrenergic beta-2 Receptor Agonists - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Albuterol - pharmacology</topic><topic>Albuterol - therapeutic use</topic><topic>Augmentation</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cardiography</topic><topic>Cardiography, Impedance</topic><topic>Ejection</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Heart rate</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Inhalation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nitroglycerin</topic><topic>Nitroglycerin - pharmacology</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Prospective Studies</topic><topic>Respiration</topic><topic>Salbutamol</topic><topic>Treatment Outcome</topic><topic>Vascular Resistance - drug effects</topic><topic>Vascular Stiffness - drug effects</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Wave analysis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tikkakoski, Antti J.</creatorcontrib><creatorcontrib>Kangas, Pauliina</creatorcontrib><creatorcontrib>Suojanen, Lauri</creatorcontrib><creatorcontrib>Tahvanainen, Anna M.</creatorcontrib><creatorcontrib>Eräranta, Arttu</creatorcontrib><creatorcontrib>Kähönen, Mika A.P.</creatorcontrib><creatorcontrib>Sipilä, Kalle</creatorcontrib><creatorcontrib>Mustonen, Jukka T.</creatorcontrib><creatorcontrib>Pörsti, Ilkka H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tikkakoski, Antti J.</au><au>Kangas, Pauliina</au><au>Suojanen, Lauri</au><au>Tahvanainen, Anna M.</au><au>Eräranta, Arttu</au><au>Kähönen, Mika A.P.</au><au>Sipilä, Kalle</au><au>Mustonen, Jukka T.</au><au>Pörsti, Ilkka H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2018-08</date><risdate>2018</risdate><volume>123</volume><issue>2</issue><spage>161</spage><epage>173</epage><pages>161-173</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>The change in augmentation index following salbutamol inhalation has been applied to evaluate endothelial function. We examined the contribution of salbutamol‐induced increase in heart rate to the observed decrease in augmentation index. Haemodynamics were recorded using whole‐body impedance cardiography and continuous pulse wave analysis from tonometric radial blood pressure. All subjects (n = 335, mean age 46, body mass index 26, 48% men) were without medications with cardiovascular influences. The effects of salbutamol inhalation (0.4 mg) versus the endothelium‐independent agent nitroglycerin resoriblet (0.25 mg) were examined during passive head‐up tilt, as the haemodynamic influences of these compounds depend on body position. Salbutamol decreased augmentation index by ~3‐4% units in supine and upright positions. Although salbutamol moderately increased cardiac index (+4.5%) and decreased systemic vascular resistance (−8.5%), the significant haemodynamic explanatory factors for decreased augmentation index in multivariate analysis were increased supine heart rate, and increased upright heart rate and decreased ejection duration (p < 0.001 for all, r2 = 0.36–0.37). Sublingual nitroglycerin decreased supine and upright augmentation index by ~15% units and ~23% units, respectively. The haemodynamic explanatory factors for these changes in multivariate analysis were increased heart rate, reduced ejection duration and reduced systemic vascular resistance (p ≤ 0.021 for all, r2 = 0.22–0.34). In conclusion, the lowering influence of salbutamol on augmentation index may be largely explained by increased heart rate, suggesting that this effect may not predominantly reflect endothelial function.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29476697</pmid><doi>10.1111/bcpt.12988</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Inhalation Administration, Sublingual Adrenergic beta-2 Receptor Agonists - pharmacology Adrenergic beta-2 Receptor Agonists - therapeutic use Adult Aged Albuterol - pharmacology Albuterol - therapeutic use Augmentation Blood pressure Blood Pressure - drug effects Body mass Body mass index Body size Cardiography Cardiography, Impedance Ejection Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Female Heart rate Heart Rate - drug effects Hemodynamics Humans Hypertension - drug therapy Inhalation Male Middle Aged Multivariate analysis Nitroglycerin Nitroglycerin - pharmacology Nitroglycerin - therapeutic use Prospective Studies Respiration Salbutamol Treatment Outcome Vascular Resistance - drug effects Vascular Stiffness - drug effects Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Wave analysis Young Adult |
| title | Salbutamol‐induced Decrease in Augmentation Index is Related to the Parallel Increase in Heart Rate |
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