Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels
In a subset of high-altitude dwellers, the appropriate erythrocytotic response becomes excessive and can result in chronic mountain sickness. We studied men with (study group) and without excessive erythrocytosis (packed-cell volume >65%) living in Cerro de Pasco, Peru (altitude 4300 m), and comp...
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| Veröffentlicht in: | The Lancet (British edition) 2002-02, Vol.359 (9304), p.407-408 |
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| creator | Jefferson, J Ashley Escudero, Elizabeth Hurtado, Maria-Elena Pando, Jacqueline Tapia, Rosario Swenson, Erik R Prchal, Josef Schreiner, George F Schoene, Robert B Hurtoado, Abdias Johnson, Richard J |
| description | In a subset of high-altitude dwellers, the appropriate erythrocytotic response becomes excessive and can result in chronic mountain sickness. We studied men with (study group) and without excessive erythrocytosis (packed-cell volume >65%) living in Cerro de Pasco, Peru (altitude 4300 m), and compared them with controls living in Lima, Peru (at sea-level). Toxic serum cobalt concentrations were detected in 11 of 21 (52%) study participants with excessive erythrocytosis, but were undetectable in high altitude or sea-level controls. In the mining community of Cerro de Pasco, cobalt toxicity might be an important contributor to excessive erythrocytosis. |
| doi_str_mv | 10.1016/S0140-6736(02)07594-3 |
| format | Article |
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In the mining community of Cerro de Pasco, cobalt toxicity might be an important contributor to excessive erythrocytosis.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(02)07594-3</identifier><identifier>PMID: 11844517</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Altitude ; Altitude Sickness - blood ; Biological and medical sciences ; Blood pressure ; Case-Control Studies ; Cell size ; Chronic Disease ; Cobalt ; Cobalt - adverse effects ; Cobalt - blood ; Correlation coefficient ; Diseases of red blood cells ; Eating disorders ; Hematologic and hematopoietic diseases ; High altitude ; Humans ; Hypoxia ; Illnesses ; Laboratories ; Male ; Mass spectroscopy ; Medical sciences ; Men ; Nickel ; Peru ; Phlebotomy ; Polycythemia ; Polycythemia - blood ; Polycythemia - etiology ; Polycythemias ; Pulmonary hypertension ; Sea level ; Toxicity ; Variance analysis</subject><ispartof>The Lancet (British edition), 2002-02, Vol.359 (9304), p.407-408</ispartof><rights>2002 Elsevier Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Lancet Ltd. 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We studied men with (study group) and without excessive erythrocytosis (packed-cell volume >65%) living in Cerro de Pasco, Peru (altitude 4300 m), and compared them with controls living in Lima, Peru (at sea-level). Toxic serum cobalt concentrations were detected in 11 of 21 (52%) study participants with excessive erythrocytosis, but were undetectable in high altitude or sea-level controls. In the mining community of Cerro de Pasco, cobalt toxicity might be an important contributor to excessive erythrocytosis.</description><subject>Adult</subject><subject>Altitude</subject><subject>Altitude Sickness - blood</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Case-Control Studies</subject><subject>Cell size</subject><subject>Chronic Disease</subject><subject>Cobalt</subject><subject>Cobalt - adverse effects</subject><subject>Cobalt - blood</subject><subject>Correlation coefficient</subject><subject>Diseases of red blood cells</subject><subject>Eating disorders</subject><subject>Hematologic and hematopoietic diseases</subject><subject>High altitude</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Illnesses</subject><subject>Laboratories</subject><subject>Male</subject><subject>Mass spectroscopy</subject><subject>Medical 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We studied men with (study group) and without excessive erythrocytosis (packed-cell volume >65%) living in Cerro de Pasco, Peru (altitude 4300 m), and compared them with controls living in Lima, Peru (at sea-level). Toxic serum cobalt concentrations were detected in 11 of 21 (52%) study participants with excessive erythrocytosis, but were undetectable in high altitude or sea-level controls. In the mining community of Cerro de Pasco, cobalt toxicity might be an important contributor to excessive erythrocytosis.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>11844517</pmid><doi>10.1016/S0140-6736(02)07594-3</doi><tpages>2</tpages></addata></record> |
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| subjects | Adult Altitude Altitude Sickness - blood Biological and medical sciences Blood pressure Case-Control Studies Cell size Chronic Disease Cobalt Cobalt - adverse effects Cobalt - blood Correlation coefficient Diseases of red blood cells Eating disorders Hematologic and hematopoietic diseases High altitude Humans Hypoxia Illnesses Laboratories Male Mass spectroscopy Medical sciences Men Nickel Peru Phlebotomy Polycythemia Polycythemia - blood Polycythemia - etiology Polycythemias Pulmonary hypertension Sea level Toxicity Variance analysis |
| title | Excessive erythrocytosis, chronic mountain sickness, and serum cobalt levels |
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