Intracellular application and logic gate behavior of a ‘turn off-on-off’ type probe for selective detection of Al^sup 3+^ and F- ions in pure aqueous medium
A new Schiff base tcph, derived from 2-thiophene carboxylic acid hydrazide, has been synthesized and characterized by various spectroscopic techniques. The molecular structure of the compound has also been determined by X-ray crystallography. The tcph acts as a selective Al3+ and F− induced OFF-ON-O...
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| Veröffentlicht in: | Sensors and actuators. B, Chemical Chemical, 2018-04, Vol.258, p.881 |
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| container_title | Sensors and actuators. B, Chemical |
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| creator | Dwivedi, Romi Singh, Divya Pratap Chauhan, Brijesh Singh Srikrishna, S Panday, Anoop Kumar Choudhury, Lokman H Singh, Vinod Prasad |
| description | A new Schiff base tcph, derived from 2-thiophene carboxylic acid hydrazide, has been synthesized and characterized by various spectroscopic techniques. The molecular structure of the compound has also been determined by X-ray crystallography. The tcph acts as a selective Al3+ and F− induced OFF-ON-OFF type of probe in aqueous media. The 1:1 binding stoichiometry between probe and Al3+ has been established from Job’s plot and further supported by ESI–MS studies. The limit of detection of Al3+ ions is determined by 3σ methods, which is found to be 1.35 × 10−9 M. The coordination environment for the tcph-Al3+ complex is delineated by NMR titration and DFT calculations. Detailed insights of probe–metal interaction mechanism have been studied by density functional theory (DFT) as well as time dependent–DFT calculations. MTT assay of the probe on live SiHa cells suggests no serious cytotoxicity in cells even at higher concentration. The probe tcph and its tcph-Al3+ complex have also been successfully applied to detect Al3+ and F− ions in living cells (SiHa cells), respectively. |
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The molecular structure of the compound has also been determined by X-ray crystallography. The tcph acts as a selective Al3+ and F− induced OFF-ON-OFF type of probe in aqueous media. The 1:1 binding stoichiometry between probe and Al3+ has been established from Job’s plot and further supported by ESI–MS studies. The limit of detection of Al3+ ions is determined by 3σ methods, which is found to be 1.35 × 10−9 M. The coordination environment for the tcph-Al3+ complex is delineated by NMR titration and DFT calculations. Detailed insights of probe–metal interaction mechanism have been studied by density functional theory (DFT) as well as time dependent–DFT calculations. MTT assay of the probe on live SiHa cells suggests no serious cytotoxicity in cells even at higher concentration. The probe tcph and its tcph-Al3+ complex have also been successfully applied to detect Al3+ and F− ions in living cells (SiHa cells), respectively.</description><identifier>ISSN: 0925-4005</identifier><identifier>EISSN: 1873-3077</identifier><language>eng</language><publisher>Lausanne: Elsevier Science Ltd</publisher><subject>Aluminum ; Cells ; Chemical synthesis ; Crystallography ; Density ; Density functional theory ; Imines ; Ions ; Logic circuits ; Mathematical analysis ; Molecular chains ; Molecular structure ; NMR ; Nuclear magnetic resonance ; Stoichiometry ; Studies ; Time dependence ; Titration ; Toxicity</subject><ispartof>Sensors and actuators. B, Chemical, 2018-04, Vol.258, p.881</ispartof><rights>Copyright Elsevier Science Ltd. 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B, Chemical</title><description>A new Schiff base tcph, derived from 2-thiophene carboxylic acid hydrazide, has been synthesized and characterized by various spectroscopic techniques. The molecular structure of the compound has also been determined by X-ray crystallography. The tcph acts as a selective Al3+ and F− induced OFF-ON-OFF type of probe in aqueous media. The 1:1 binding stoichiometry between probe and Al3+ has been established from Job’s plot and further supported by ESI–MS studies. The limit of detection of Al3+ ions is determined by 3σ methods, which is found to be 1.35 × 10−9 M. The coordination environment for the tcph-Al3+ complex is delineated by NMR titration and DFT calculations. Detailed insights of probe–metal interaction mechanism have been studied by density functional theory (DFT) as well as time dependent–DFT calculations. MTT assay of the probe on live SiHa cells suggests no serious cytotoxicity in cells even at higher concentration. The probe tcph and its tcph-Al3+ complex have also been successfully applied to detect Al3+ and F− ions in living cells (SiHa cells), respectively.</description><subject>Aluminum</subject><subject>Cells</subject><subject>Chemical synthesis</subject><subject>Crystallography</subject><subject>Density</subject><subject>Density functional theory</subject><subject>Imines</subject><subject>Ions</subject><subject>Logic circuits</subject><subject>Mathematical analysis</subject><subject>Molecular chains</subject><subject>Molecular structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Stoichiometry</subject><subject>Studies</subject><subject>Time dependence</subject><subject>Titration</subject><subject>Toxicity</subject><issn>0925-4005</issn><issn>1873-3077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqNjktOAzEQRC1EJIbPHVpiiSw58XxgiRAR7Fkn6sz0JI4ct_EnErscA3acLSfBQRyAVXWpXqn6TFTT-05LrbruXFTqYdbIWqnmQlzGuFVK1bpVlfh-dSlgT9ZmiwHQe2t6TIYdoBvA8tr0sMZEsKIN7g0H4BEQjofPlIMrZpTsZJHj4QvShyfwgVcEYyEjWeqT2RMMlE4XnwrwaBcxe9B3i9-NuYQSRDAOfA4E-J6Jc4QdDSbvrsVkRBvp5k-vxO38-e3pRZaZAsa03HJ5pETLmWo73Ta6nur_UT8INl5w</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Dwivedi, Romi</creator><creator>Singh, Divya Pratap</creator><creator>Chauhan, Brijesh Singh</creator><creator>Srikrishna, S</creator><creator>Panday, Anoop Kumar</creator><creator>Choudhury, Lokman H</creator><creator>Singh, Vinod Prasad</creator><general>Elsevier Science Ltd</general><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20180401</creationdate><title>Intracellular application and logic gate behavior of a ‘turn off-on-off’ type probe for selective detection of Al^sup 3+^ and F- ions in pure aqueous medium</title><author>Dwivedi, Romi ; Singh, Divya Pratap ; Chauhan, Brijesh Singh ; Srikrishna, S ; Panday, Anoop Kumar ; Choudhury, Lokman H ; Singh, Vinod Prasad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_20673653413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aluminum</topic><topic>Cells</topic><topic>Chemical synthesis</topic><topic>Crystallography</topic><topic>Density</topic><topic>Density functional theory</topic><topic>Imines</topic><topic>Ions</topic><topic>Logic circuits</topic><topic>Mathematical analysis</topic><topic>Molecular chains</topic><topic>Molecular structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Stoichiometry</topic><topic>Studies</topic><topic>Time dependence</topic><topic>Titration</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dwivedi, Romi</creatorcontrib><creatorcontrib>Singh, Divya Pratap</creatorcontrib><creatorcontrib>Chauhan, Brijesh Singh</creatorcontrib><creatorcontrib>Srikrishna, S</creatorcontrib><creatorcontrib>Panday, Anoop Kumar</creatorcontrib><creatorcontrib>Choudhury, Lokman H</creatorcontrib><creatorcontrib>Singh, Vinod Prasad</creatorcontrib><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Sensors and actuators. 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The molecular structure of the compound has also been determined by X-ray crystallography. The tcph acts as a selective Al3+ and F− induced OFF-ON-OFF type of probe in aqueous media. The 1:1 binding stoichiometry between probe and Al3+ has been established from Job’s plot and further supported by ESI–MS studies. The limit of detection of Al3+ ions is determined by 3σ methods, which is found to be 1.35 × 10−9 M. The coordination environment for the tcph-Al3+ complex is delineated by NMR titration and DFT calculations. Detailed insights of probe–metal interaction mechanism have been studied by density functional theory (DFT) as well as time dependent–DFT calculations. MTT assay of the probe on live SiHa cells suggests no serious cytotoxicity in cells even at higher concentration. 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| ispartof | Sensors and actuators. B, Chemical, 2018-04, Vol.258, p.881 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Aluminum Cells Chemical synthesis Crystallography Density Density functional theory Imines Ions Logic circuits Mathematical analysis Molecular chains Molecular structure NMR Nuclear magnetic resonance Stoichiometry Studies Time dependence Titration Toxicity |
| title | Intracellular application and logic gate behavior of a ‘turn off-on-off’ type probe for selective detection of Al^sup 3+^ and F- ions in pure aqueous medium |
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