Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche
Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour 1 , 2 . The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The...
Gespeichert in:
| Veröffentlicht in: | Nature (London) 2018-06, Vol.558 (7710), p.445-448 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 448 |
|---|---|
| container_issue | 7710 |
| container_start_page | 445 |
| container_title | Nature (London) |
| container_volume | 558 |
| creator | Kapp, Friedrich G. Perlin, Julie R. Hagedorn, Elliott J. Gansner, John M. Schwarz, Daniel E. O’Connell, Lauren A. Johnson, Nicholas S. Amemiya, Chris Fisher, David E. Wölfle, Ute Trompouki, Eirini Niemeyer, Charlotte M. Driever, Wolfgang Zon, Leonard I. |
| description | Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour
1
,
2
. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by
cmyb
(also known as
myb
) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.
Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life. |
| doi_str_mv | 10.1038/s41586-018-0213-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2067321692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A572642900</galeid><sourcerecordid>A572642900</sourcerecordid><originalsourceid>FETCH-LOGICAL-c684t-96466d5415d2a5ad8f903797510bd3e8c6f213951f38e48f864040557ec190423</originalsourceid><addsrcrecordid>eNp1kk9vFSEUxYnR2Gf1A7gxRFcupgIDDCybxj9NmmjUunFBKHOZRzMzvALT2G8vL69qX_IMCxLO7xxybw5CLyk5oaRV7zKnQsmGUNUQRtuGPEIryjvZcKm6x2hFCKuKauURepbzNSFE0I4_RUdMK605Vyv080uKBVwJccY-xQlf_sBjGNYFh4ztjOE2jstWtSmMd9jFOUO6hR57sGVJgKPHZQ14bWGyJW5igBIcnoNbw3P0xNsxw4v7-xhdfnj__exTc_H54_nZ6UXjpOKl0ZJL2Ys6S8-ssL3ymrSd7gQlV30Lyklfh9OC-lYBV15JTjgRogNHNeGsPUZvdrmbFG8WyMVcxyXN9UvDiOxaRqV-QA12BBNmH0uybgrZmVPRMcmZJqRSzQFqgBmSHeMMPtTnPf71Ad5two15CJ0cgOrpYQruYOrbPUNlCvwqg11yNuffvu6zdMe6FHNO4M0mhcmmO0OJ2dbE7Gpiak3MtiZm63l1v7HlaoL-r-NPLyrAdkCu0jxA-rfS_6f-Bq3mwqM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2067321692</pqid></control><display><type>article</type><title>Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature</source><creator>Kapp, Friedrich G. ; Perlin, Julie R. ; Hagedorn, Elliott J. ; Gansner, John M. ; Schwarz, Daniel E. ; O’Connell, Lauren A. ; Johnson, Nicholas S. ; Amemiya, Chris ; Fisher, David E. ; Wölfle, Ute ; Trompouki, Eirini ; Niemeyer, Charlotte M. ; Driever, Wolfgang ; Zon, Leonard I.</creator><creatorcontrib>Kapp, Friedrich G. ; Perlin, Julie R. ; Hagedorn, Elliott J. ; Gansner, John M. ; Schwarz, Daniel E. ; O’Connell, Lauren A. ; Johnson, Nicholas S. ; Amemiya, Chris ; Fisher, David E. ; Wölfle, Ute ; Trompouki, Eirini ; Niemeyer, Charlotte M. ; Driever, Wolfgang ; Zon, Leonard I.</creatorcontrib><description>Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour
1
,
2
. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by
cmyb
(also known as
myb
) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.
Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/s41586-018-0213-0</identifier><identifier>PMID: 29899448</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/51 ; 14 ; 14/19 ; 14/35 ; 14/63 ; 631/136/232 ; 631/136/334/1874/763 ; 631/136/532/1542 ; 631/181/2806 ; 631/532/2139 ; 64/116 ; Animals ; Aquatic animals ; Aquatic environment ; Aquatic Organisms - classification ; Biodiversity conservation ; Biological Evolution ; Bone marrow ; Brain ; Cells (biology) ; Cortical bone ; Cyclobutane ; Cyclobutane pyrimidine dimers ; Cytoprotection - radiation effects ; Danio rerio ; Deoxyribonucleic acid ; Dimers ; DNA ; DNA damage ; DNA Damage - radiation effects ; Environmental aspects ; Evolution ; Gene expression ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - radiation effects ; Humanities and Social Sciences ; Irradiation ; Kidney ; Kidneys ; Laboratories ; Larvae ; Letter ; Light ; Light irradiation ; Mammals ; Melanocytes ; Melanocytes - cytology ; Melanocytes - radiation effects ; Methods ; Microenvironments ; multidisciplinary ; Mutation ; Niches ; Petromyzon - classification ; Phylogeny ; Progenitor cells ; Pyrimidine Dimers - radiation effects ; Pyrimidines ; Radiation damage ; Science ; Science (multidisciplinary) ; Siblings ; Stem Cell Niche - physiology ; Stem Cell Niche - radiation effects ; Stem cells ; Terrestrial ecosystems ; Terrestrial environments ; Transcription factors ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects ; Vertebrates ; Wildlife conservation ; Zebrafish ; Zebrafish - classification ; Zebrafish - genetics</subject><ispartof>Nature (London), 2018-06, Vol.558 (7710), p.445-448</ispartof><rights>Macmillan Publishers Ltd., part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 21, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c684t-96466d5415d2a5ad8f903797510bd3e8c6f213951f38e48f864040557ec190423</citedby><cites>FETCH-LOGICAL-c684t-96466d5415d2a5ad8f903797510bd3e8c6f213951f38e48f864040557ec190423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41586-018-0213-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41586-018-0213-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29899448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kapp, Friedrich G.</creatorcontrib><creatorcontrib>Perlin, Julie R.</creatorcontrib><creatorcontrib>Hagedorn, Elliott J.</creatorcontrib><creatorcontrib>Gansner, John M.</creatorcontrib><creatorcontrib>Schwarz, Daniel E.</creatorcontrib><creatorcontrib>O’Connell, Lauren A.</creatorcontrib><creatorcontrib>Johnson, Nicholas S.</creatorcontrib><creatorcontrib>Amemiya, Chris</creatorcontrib><creatorcontrib>Fisher, David E.</creatorcontrib><creatorcontrib>Wölfle, Ute</creatorcontrib><creatorcontrib>Trompouki, Eirini</creatorcontrib><creatorcontrib>Niemeyer, Charlotte M.</creatorcontrib><creatorcontrib>Driever, Wolfgang</creatorcontrib><creatorcontrib>Zon, Leonard I.</creatorcontrib><title>Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour
1
,
2
. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by
cmyb
(also known as
myb
) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.
Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.</description><subject>13/51</subject><subject>14</subject><subject>14/19</subject><subject>14/35</subject><subject>14/63</subject><subject>631/136/232</subject><subject>631/136/334/1874/763</subject><subject>631/136/532/1542</subject><subject>631/181/2806</subject><subject>631/532/2139</subject><subject>64/116</subject><subject>Animals</subject><subject>Aquatic animals</subject><subject>Aquatic environment</subject><subject>Aquatic Organisms - classification</subject><subject>Biodiversity conservation</subject><subject>Biological Evolution</subject><subject>Bone marrow</subject><subject>Brain</subject><subject>Cells (biology)</subject><subject>Cortical bone</subject><subject>Cyclobutane</subject><subject>Cyclobutane pyrimidine dimers</subject><subject>Cytoprotection - radiation effects</subject><subject>Danio rerio</subject><subject>Deoxyribonucleic acid</subject><subject>Dimers</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - radiation effects</subject><subject>Environmental aspects</subject><subject>Evolution</subject><subject>Gene expression</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - radiation effects</subject><subject>Humanities and Social Sciences</subject><subject>Irradiation</subject><subject>Kidney</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Larvae</subject><subject>Letter</subject><subject>Light</subject><subject>Light irradiation</subject><subject>Mammals</subject><subject>Melanocytes</subject><subject>Melanocytes - cytology</subject><subject>Melanocytes - radiation effects</subject><subject>Methods</subject><subject>Microenvironments</subject><subject>multidisciplinary</subject><subject>Mutation</subject><subject>Niches</subject><subject>Petromyzon - classification</subject><subject>Phylogeny</subject><subject>Progenitor cells</subject><subject>Pyrimidine Dimers - radiation effects</subject><subject>Pyrimidines</subject><subject>Radiation damage</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Siblings</subject><subject>Stem Cell Niche - physiology</subject><subject>Stem Cell Niche - radiation effects</subject><subject>Stem cells</subject><subject>Terrestrial ecosystems</subject><subject>Terrestrial environments</subject><subject>Transcription factors</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>Vertebrates</subject><subject>Wildlife conservation</subject><subject>Zebrafish</subject><subject>Zebrafish - classification</subject><subject>Zebrafish - genetics</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk9vFSEUxYnR2Gf1A7gxRFcupgIDDCybxj9NmmjUunFBKHOZRzMzvALT2G8vL69qX_IMCxLO7xxybw5CLyk5oaRV7zKnQsmGUNUQRtuGPEIryjvZcKm6x2hFCKuKauURepbzNSFE0I4_RUdMK605Vyv080uKBVwJccY-xQlf_sBjGNYFh4ztjOE2jstWtSmMd9jFOUO6hR57sGVJgKPHZQ14bWGyJW5igBIcnoNbw3P0xNsxw4v7-xhdfnj__exTc_H54_nZ6UXjpOKl0ZJL2Ys6S8-ssL3ymrSd7gQlV30Lyklfh9OC-lYBV15JTjgRogNHNeGsPUZvdrmbFG8WyMVcxyXN9UvDiOxaRqV-QA12BBNmH0uybgrZmVPRMcmZJqRSzQFqgBmSHeMMPtTnPf71Ad5two15CJ0cgOrpYQruYOrbPUNlCvwqg11yNuffvu6zdMe6FHNO4M0mhcmmO0OJ2dbE7Gpiak3MtiZm63l1v7HlaoL-r-NPLyrAdkCu0jxA-rfS_6f-Bq3mwqM</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Kapp, Friedrich G.</creator><creator>Perlin, Julie R.</creator><creator>Hagedorn, Elliott J.</creator><creator>Gansner, John M.</creator><creator>Schwarz, Daniel E.</creator><creator>O’Connell, Lauren A.</creator><creator>Johnson, Nicholas S.</creator><creator>Amemiya, Chris</creator><creator>Fisher, David E.</creator><creator>Wölfle, Ute</creator><creator>Trompouki, Eirini</creator><creator>Niemeyer, Charlotte M.</creator><creator>Driever, Wolfgang</creator><creator>Zon, Leonard I.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>S0X</scope><scope>SOI</scope></search><sort><creationdate>201806</creationdate><title>Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche</title><author>Kapp, Friedrich G. ; Perlin, Julie R. ; Hagedorn, Elliott J. ; Gansner, John M. ; Schwarz, Daniel E. ; O’Connell, Lauren A. ; Johnson, Nicholas S. ; Amemiya, Chris ; Fisher, David E. ; Wölfle, Ute ; Trompouki, Eirini ; Niemeyer, Charlotte M. ; Driever, Wolfgang ; Zon, Leonard I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c684t-96466d5415d2a5ad8f903797510bd3e8c6f213951f38e48f864040557ec190423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/51</topic><topic>14</topic><topic>14/19</topic><topic>14/35</topic><topic>14/63</topic><topic>631/136/232</topic><topic>631/136/334/1874/763</topic><topic>631/136/532/1542</topic><topic>631/181/2806</topic><topic>631/532/2139</topic><topic>64/116</topic><topic>Animals</topic><topic>Aquatic animals</topic><topic>Aquatic environment</topic><topic>Aquatic Organisms - classification</topic><topic>Biodiversity conservation</topic><topic>Biological Evolution</topic><topic>Bone marrow</topic><topic>Brain</topic><topic>Cells (biology)</topic><topic>Cortical bone</topic><topic>Cyclobutane</topic><topic>Cyclobutane pyrimidine dimers</topic><topic>Cytoprotection - radiation effects</topic><topic>Danio rerio</topic><topic>Deoxyribonucleic acid</topic><topic>Dimers</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - radiation effects</topic><topic>Environmental aspects</topic><topic>Evolution</topic><topic>Gene expression</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - radiation effects</topic><topic>Humanities and Social Sciences</topic><topic>Irradiation</topic><topic>Kidney</topic><topic>Kidneys</topic><topic>Laboratories</topic><topic>Larvae</topic><topic>Letter</topic><topic>Light</topic><topic>Light irradiation</topic><topic>Mammals</topic><topic>Melanocytes</topic><topic>Melanocytes - cytology</topic><topic>Melanocytes - radiation effects</topic><topic>Methods</topic><topic>Microenvironments</topic><topic>multidisciplinary</topic><topic>Mutation</topic><topic>Niches</topic><topic>Petromyzon - classification</topic><topic>Phylogeny</topic><topic>Progenitor cells</topic><topic>Pyrimidine Dimers - radiation effects</topic><topic>Pyrimidines</topic><topic>Radiation damage</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Siblings</topic><topic>Stem Cell Niche - physiology</topic><topic>Stem Cell Niche - radiation effects</topic><topic>Stem cells</topic><topic>Terrestrial ecosystems</topic><topic>Terrestrial environments</topic><topic>Transcription factors</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>Vertebrates</topic><topic>Wildlife conservation</topic><topic>Zebrafish</topic><topic>Zebrafish - classification</topic><topic>Zebrafish - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kapp, Friedrich G.</creatorcontrib><creatorcontrib>Perlin, Julie R.</creatorcontrib><creatorcontrib>Hagedorn, Elliott J.</creatorcontrib><creatorcontrib>Gansner, John M.</creatorcontrib><creatorcontrib>Schwarz, Daniel E.</creatorcontrib><creatorcontrib>O’Connell, Lauren A.</creatorcontrib><creatorcontrib>Johnson, Nicholas S.</creatorcontrib><creatorcontrib>Amemiya, Chris</creatorcontrib><creatorcontrib>Fisher, David E.</creatorcontrib><creatorcontrib>Wölfle, Ute</creatorcontrib><creatorcontrib>Trompouki, Eirini</creatorcontrib><creatorcontrib>Niemeyer, Charlotte M.</creatorcontrib><creatorcontrib>Driever, Wolfgang</creatorcontrib><creatorcontrib>Zon, Leonard I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kapp, Friedrich G.</au><au>Perlin, Julie R.</au><au>Hagedorn, Elliott J.</au><au>Gansner, John M.</au><au>Schwarz, Daniel E.</au><au>O’Connell, Lauren A.</au><au>Johnson, Nicholas S.</au><au>Amemiya, Chris</au><au>Fisher, David E.</au><au>Wölfle, Ute</au><au>Trompouki, Eirini</au><au>Niemeyer, Charlotte M.</au><au>Driever, Wolfgang</au><au>Zon, Leonard I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>2018-06</date><risdate>2018</risdate><volume>558</volume><issue>7710</issue><spage>445</spage><epage>448</epage><pages>445-448</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>Haematopoietic stem and progenitor cells (HSPCs) require a specific microenvironment, the haematopoietic niche, which regulates HSPC behaviour
1
,
2
. The location of this niche varies across species, but the evolutionary pressures that drive HSPCs to different microenvironments remain unknown. The niche is located in the bone marrow in adult mammals, whereas it is found in other locations in non-mammalian vertebrates, for example, in the kidney marrow in teleost fish. Here we show that a melanocyte umbrella above the kidney marrow protects HSPCs against ultraviolet light in zebrafish. Because mutants that lack melanocytes have normal steady-state haematopoiesis under standard laboratory conditions, we hypothesized that melanocytes above the stem cell niche protect HSPCs against ultraviolet-light-induced DNA damage. Indeed, after ultraviolet-light irradiation, unpigmented larvae show higher levels of DNA damage in HSPCs, as indicated by staining of cyclobutane pyrimidine dimers and have reduced numbers of HSPCs, as shown by
cmyb
(also known as
myb
) expression. The umbrella of melanocytes associated with the haematopoietic niche is highly evolutionarily conserved in aquatic animals, including the sea lamprey, a basal vertebrate. During the transition from an aquatic to a terrestrial environment, HSPCs relocated into the bone marrow, which is protected from ultraviolet light by the cortical bone around the marrow. Our studies reveal that melanocytes above the haematopoietic niche protect HSPCs from ultraviolet-light-induced DNA damage in aquatic vertebrates and suggest that during the transition to terrestrial life, ultraviolet light was an evolutionary pressure affecting the location of the haematopoietic niche.
Melanocytes above the haematopoietic niche protect haematopoietic stem cells from ultraviolet-light-induced DNA damage in aquatic vertebrates throughout evolution; this niche moved to the bone marrow during the transition to terrestrial life.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29899448</pmid><doi>10.1038/s41586-018-0213-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 2018-06, Vol.558 (7710), p.445-448 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_journals_2067321692 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 13/51 14 14/19 14/35 14/63 631/136/232 631/136/334/1874/763 631/136/532/1542 631/181/2806 631/532/2139 64/116 Animals Aquatic animals Aquatic environment Aquatic Organisms - classification Biodiversity conservation Biological Evolution Bone marrow Brain Cells (biology) Cortical bone Cyclobutane Cyclobutane pyrimidine dimers Cytoprotection - radiation effects Danio rerio Deoxyribonucleic acid Dimers DNA DNA damage DNA Damage - radiation effects Environmental aspects Evolution Gene expression Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - radiation effects Humanities and Social Sciences Irradiation Kidney Kidneys Laboratories Larvae Letter Light Light irradiation Mammals Melanocytes Melanocytes - cytology Melanocytes - radiation effects Methods Microenvironments multidisciplinary Mutation Niches Petromyzon - classification Phylogeny Progenitor cells Pyrimidine Dimers - radiation effects Pyrimidines Radiation damage Science Science (multidisciplinary) Siblings Stem Cell Niche - physiology Stem Cell Niche - radiation effects Stem cells Terrestrial ecosystems Terrestrial environments Transcription factors Ultraviolet radiation Ultraviolet Rays - adverse effects Vertebrates Wildlife conservation Zebrafish Zebrafish - classification Zebrafish - genetics |
| title | Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T00%3A48%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protection%20from%20UV%20light%20is%20an%20evolutionarily%20conserved%20feature%20of%20the%20haematopoietic%20niche&rft.jtitle=Nature%20(London)&rft.au=Kapp,%20Friedrich%20G.&rft.date=2018-06&rft.volume=558&rft.issue=7710&rft.spage=445&rft.epage=448&rft.pages=445-448&rft.issn=0028-0836&rft.eissn=1476-4687&rft_id=info:doi/10.1038/s41586-018-0213-0&rft_dat=%3Cgale_proqu%3EA572642900%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2067321692&rft_id=info:pmid/29899448&rft_galeid=A572642900&rfr_iscdi=true |