Heat‐shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS

A dominant mutation in the gene for copper‐zinc superoxide dismutase (SOD1) is the most frequent cause of the inherited form of amyotrophic lateral sclerosis. Mutant SOD1 provokes progressive degeneration of motor neurons by an unidentified acquired toxicity. Exploiting both affinity purification an...

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Veröffentlicht in:	Journal of neurochemistry 2007-09, Vol.102 (5), p.1497-1505
Hauptverfasser:	Yamashita, Hirofumi, Kawamata, Jun, Okawa, Katsuya, Kanki, Rie, Nakamizo, Tomoki, Hatayama, Takumi, Yamanaka, Koji, Takahashi, Ryosuke, Shimohama, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amyotrophic lateral sclerosis Analysis of Variance Animals Biochemistry Biological and medical sciences Cell Line Cellular biology Cu/Zn superoxide dismutase (or superoxide dismutase 1) Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Gene Expression Regulation - physiology Genetics heat‐shock protein 105 HSP110 Heat-Shock Proteins - metabolism Humans Immunoprecipitation Mass Spectrometry Medical sciences Mice Mice, Transgenic Motor Neurons - metabolism Mutation Mutation - physiology Neuroblastoma Neurology Proteins Spinal Cord - cytology Spinal Cord - metabolism Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Transfection Tumors of the nervous system. Phacomatoses
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