Effects of human apolipoprotein E isoforms on the amyloid [beta]-protein concentration and lipid composition in brain low-density membrane domains

Apolipoprotein E4 (apoE4) encoded by Epsilon4 allele is a strong genetic risk factor for Alzheimer's disease (AD). ApoE4 carriers have accelerated amyloid Beta-protein (ABeta) deposition in their brains, which may account for their unusual susceptibility to AD. We hypothesized that the accelera...

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Veröffentlicht in:	Journal of neurochemistry 2007-05, Vol.101 (4), p.949
Hauptverfasser:	Morishima-Kawashima, Maho, Han, Xianlin, Tanimura, Yu, Hamanaka, Hiroki, Kobayashi, Mariko, Sakurai, Takashi, Yokoyama, Minesuke, Wada, Koji, Nukina, Nobuyuki, Fujita, Shinobu C, Ihara, Yasuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Brain Hypotheses Lipids Neurosciences Proteins Risk factors Rodents
Online-Zugang:	Volltext
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