Disruption of postsynaptic GABAA receptor clusters leads to decreased GABAergic innervation of pyramidal neurons

We have used RNA interference (RNAi) to knock down the expression of the γ2 subunit of the GABAA receptors (GABAARs) in pyramidal neurons in culture and in the intact brain. Two hairpin small interference RNAs (shRNAs) for the γ2 subunit, one targeting the coding region and the other one the 3′‐untr...

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