Amplification of depolarization‐induced and ryanodine‐sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP‐ribose and their antagonistic effects in NG108‐15 neuronal cells
We synthesized analogs modified in the ribose unit (ribose linked to N1 of adenine) of cyclic ADP‐ribose (cADPR), a Ca2+‐mobilizing second messenger. The biological activities of these analogs were determined in NG108‐15 neuroblastoma × glioma hybrid cells that were pre‐loaded with fura‐2 acetoxymet...
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| Veröffentlicht in: | Journal of neurochemistry 2005-07, Vol.94 (2), p.316-323 |
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| creator | Hashii, Minako Shuto, Satoshi Fukuoka, Masayoshi Kudoh, Takashi Matsuda, Akira Higashida, Haruhiro |
| description | We synthesized analogs modified in the ribose unit (ribose linked to N1 of adenine) of cyclic ADP‐ribose (cADPR), a Ca2+‐mobilizing second messenger. The biological activities of these analogs were determined in NG108‐15 neuroblastoma × glioma hybrid cells that were pre‐loaded with fura‐2 acetoxymethylester and subjected to whole‐cell patch‐clamp. Application of the hydrolysis‐resistant cyclic ADP‐carbocyclic‐ribose (cADPcR) through patch pipettes potentiated elevation of the cytoplasmic free Ca2+ concentration ([Ca2+]i) at the depolarized membrane potential. The increase in [Ca2+]i evoked upon sustained membrane depolarization was significantly larger in cADPcR‐infused cells than in non‐infused cells and its degree was equivalent to or significantly greater than that induced by cADPR or β‐NAD+. 8‐chloro‐cADPcR and two inosine congeners (cyclic IDP‐carbocyclic‐ribose and 8‐bromo‐cyclic IDP‐carbocyclic‐ribose) did not induce effects similar to those of cADPcR or cADPR. Instead, 8‐chloro‐cADPcR together with cADPR or cADPcR caused inhibition of the depolarization‐induced [Ca2+]i increase as compared with either cADPR or cADPcR alone. These results demonstrated that our cADPR analogs have agonistic or antagonistic effects on the depolarization‐induced [Ca2+]i increase and suggested the presence of functional reciprocal coupling between ryanodine receptors and voltage‐activated Ca2+ channels via cADPR in mammalian neuronal cells. |
| doi_str_mv | 10.1111/j.1471-4159.2005.03197.x |
| format | Article |
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The biological activities of these analogs were determined in NG108‐15 neuroblastoma × glioma hybrid cells that were pre‐loaded with fura‐2 acetoxymethylester and subjected to whole‐cell patch‐clamp. Application of the hydrolysis‐resistant cyclic ADP‐carbocyclic‐ribose (cADPcR) through patch pipettes potentiated elevation of the cytoplasmic free Ca2+ concentration ([Ca2+]i) at the depolarized membrane potential. The increase in [Ca2+]i evoked upon sustained membrane depolarization was significantly larger in cADPcR‐infused cells than in non‐infused cells and its degree was equivalent to or significantly greater than that induced by cADPR or β‐NAD+. 8‐chloro‐cADPcR and two inosine congeners (cyclic IDP‐carbocyclic‐ribose and 8‐bromo‐cyclic IDP‐carbocyclic‐ribose) did not induce effects similar to those of cADPcR or cADPR. Instead, 8‐chloro‐cADPcR together with cADPR or cADPcR caused inhibition of the depolarization‐induced [Ca2+]i increase as compared with either cADPR or cADPcR alone. These results demonstrated that our cADPR analogs have agonistic or antagonistic effects on the depolarization‐induced [Ca2+]i increase and suggested the presence of functional reciprocal coupling between ryanodine receptors and voltage‐activated Ca2+ channels via cADPR in mammalian neuronal cells.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.2005.03197.x</identifier><identifier>PMID: 15998283</identifier><identifier>CODEN: JONRA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Ageing, cell death ; Animals ; Biological and medical sciences ; Calcium ; Calcium - metabolism ; Calcium Channel Blockers - pharmacology ; Cell Line ; Cell physiology ; Cells ; Cyclic ADP-Ribose - analogs & derivatives ; Cyclic ADP-Ribose - chemical synthesis ; Cyclic ADP-Ribose - pharmacology ; cyclic ADP‐ribose ; Cytoplasm - drug effects ; Cytoplasm - metabolism ; cytoplasmic free Ca2+ concentration ; Dose-Response Relationship, Drug ; Drug Interactions ; Electric Stimulation - methods ; Fundamental and applied biological sciences. Psychology ; Fura-2 - metabolism ; Ions ; Medical sciences ; Membrane Potentials - drug effects ; Membrane Potentials - radiation effects ; Mice ; Molecular and cellular biology ; Neural Inhibition - drug effects ; Neural Inhibition - physiology ; Neuroblastoma ; neuroblastoma NG108‐15 cells ; Neurology ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Neurons - radiation effects ; Nifedipine - pharmacology ; Patch-Clamp Techniques - methods ; Ruthenium - pharmacology ; Ryanodine - pharmacology ; ryanodine receptor ; Tumors of the nervous system. Phacomatoses ; β‐nicotinamide adenine dinucleotide</subject><ispartof>Journal of neurochemistry, 2005-07, Vol.94 (2), p.316-323</ispartof><rights>2006 INIST-CNRS</rights><rights>2005 International Society for Neurochemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.2005.03197.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.2005.03197.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16897757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15998283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hashii, Minako</creatorcontrib><creatorcontrib>Shuto, Satoshi</creatorcontrib><creatorcontrib>Fukuoka, Masayoshi</creatorcontrib><creatorcontrib>Kudoh, Takashi</creatorcontrib><creatorcontrib>Matsuda, Akira</creatorcontrib><creatorcontrib>Higashida, Haruhiro</creatorcontrib><title>Amplification of depolarization‐induced and ryanodine‐sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP‐ribose and their antagonistic effects in NG108‐15 neuronal cells</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>We synthesized analogs modified in the ribose unit (ribose linked to N1 of adenine) of cyclic ADP‐ribose (cADPR), a Ca2+‐mobilizing second messenger. The biological activities of these analogs were determined in NG108‐15 neuroblastoma × glioma hybrid cells that were pre‐loaded with fura‐2 acetoxymethylester and subjected to whole‐cell patch‐clamp. Application of the hydrolysis‐resistant cyclic ADP‐carbocyclic‐ribose (cADPcR) through patch pipettes potentiated elevation of the cytoplasmic free Ca2+ concentration ([Ca2+]i) at the depolarized membrane potential. The increase in [Ca2+]i evoked upon sustained membrane depolarization was significantly larger in cADPcR‐infused cells than in non‐infused cells and its degree was equivalent to or significantly greater than that induced by cADPR or β‐NAD+. 8‐chloro‐cADPcR and two inosine congeners (cyclic IDP‐carbocyclic‐ribose and 8‐bromo‐cyclic IDP‐carbocyclic‐ribose) did not induce effects similar to those of cADPcR or cADPR. Instead, 8‐chloro‐cADPcR together with cADPR or cADPcR caused inhibition of the depolarization‐induced [Ca2+]i increase as compared with either cADPR or cADPcR alone. These results demonstrated that our cADPR analogs have agonistic or antagonistic effects on the depolarization‐induced [Ca2+]i increase and suggested the presence of functional reciprocal coupling between ryanodine receptors and voltage‐activated Ca2+ channels via cADPR in mammalian neuronal cells.</description><subject>Ageing, cell death</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cell Line</subject><subject>Cell physiology</subject><subject>Cells</subject><subject>Cyclic ADP-Ribose - analogs & derivatives</subject><subject>Cyclic ADP-Ribose - chemical synthesis</subject><subject>Cyclic ADP-Ribose - pharmacology</subject><subject>cyclic ADP‐ribose</subject><subject>Cytoplasm - drug effects</subject><subject>Cytoplasm - metabolism</subject><subject>cytoplasmic free Ca2+ concentration</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Electric Stimulation - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fura-2 - metabolism</subject><subject>Ions</subject><subject>Medical sciences</subject><subject>Membrane Potentials - drug effects</subject><subject>Membrane Potentials - radiation effects</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Neural Inhibition - drug effects</subject><subject>Neural Inhibition - physiology</subject><subject>Neuroblastoma</subject><subject>neuroblastoma NG108‐15 cells</subject><subject>Neurology</subject><subject>Neurons</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Neurons - radiation effects</subject><subject>Nifedipine - pharmacology</subject><subject>Patch-Clamp Techniques - methods</subject><subject>Ruthenium - pharmacology</subject><subject>Ryanodine - pharmacology</subject><subject>ryanodine receptor</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>β‐nicotinamide adenine dinucleotide</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkktuFDEQhi0EIkPgCshCYoW68aNfXrAYDRBAUWABa8vtR_DIYw92d0iz4ggcjTNwEuyZgXjjUv1f_WW5CgCIUY3zebmtcdPjqsEtqwlCbY0oZn19ew-s_gv3wQohQiqKGnIGHqW0RQh3TYcfgrMss4EMdAV-r3d7Z42VYrLBw2Cg0vvgRLQ_Dpk_P39Zr2apFRRewbgIH5T1OueT9slO9kZDuUwhBWcl3AjyAmqnb4524wLT4qevesqaFHEMcpGFE164cJ1Kv1Nm_fpT9ox2DEkfWuUqG3M0ievgbSoO2hgtpwSth1cXGA25ALfQ6zmG7Aeldi49Bg-McEk_Od3n4MvbN58376rLjxfvN-vLyhPW9BVWSvVEE9pTyrqxYUQPyjDcDhJTRZDpaEOpoX2DsGJCGiLEyJhgtBWs71t6Dp4dffcxfJt1mvg2zDE_I3GCurYhpMMZenqC5nGnFd9HuxNx4f_-PwPPT4BIUjgThZc23XHdUJr1mXt15L5bp5c7HfGyD3zLy9h5GTsv-8AP-8Bv-YerTYnoX-Byr6U</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Hashii, Minako</creator><creator>Shuto, Satoshi</creator><creator>Fukuoka, Masayoshi</creator><creator>Kudoh, Takashi</creator><creator>Matsuda, Akira</creator><creator>Higashida, Haruhiro</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>200507</creationdate><title>Amplification of depolarization‐induced and ryanodine‐sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP‐ribose and their antagonistic effects in NG108‐15 neuronal cells</title><author>Hashii, Minako ; Shuto, Satoshi ; Fukuoka, Masayoshi ; Kudoh, Takashi ; Matsuda, Akira ; Higashida, Haruhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n2947-1ddd72e2373396b492e8df9158c13d20f63433f37401d9acf2aab99a935a97753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Ageing, cell death</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>Cell Line</topic><topic>Cell physiology</topic><topic>Cells</topic><topic>Cyclic ADP-Ribose - analogs & derivatives</topic><topic>Cyclic ADP-Ribose - chemical synthesis</topic><topic>Cyclic ADP-Ribose - pharmacology</topic><topic>cyclic ADP‐ribose</topic><topic>Cytoplasm - drug effects</topic><topic>Cytoplasm - metabolism</topic><topic>cytoplasmic free Ca2+ concentration</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Electric Stimulation - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fura-2 - metabolism</topic><topic>Ions</topic><topic>Medical sciences</topic><topic>Membrane Potentials - drug effects</topic><topic>Membrane Potentials - radiation effects</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Neural Inhibition - drug effects</topic><topic>Neural Inhibition - physiology</topic><topic>Neuroblastoma</topic><topic>neuroblastoma NG108‐15 cells</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Neurons - radiation effects</topic><topic>Nifedipine - pharmacology</topic><topic>Patch-Clamp Techniques - methods</topic><topic>Ruthenium - pharmacology</topic><topic>Ryanodine - pharmacology</topic><topic>ryanodine receptor</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>β‐nicotinamide adenine dinucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hashii, Minako</creatorcontrib><creatorcontrib>Shuto, Satoshi</creatorcontrib><creatorcontrib>Fukuoka, Masayoshi</creatorcontrib><creatorcontrib>Kudoh, Takashi</creatorcontrib><creatorcontrib>Matsuda, Akira</creatorcontrib><creatorcontrib>Higashida, Haruhiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hashii, Minako</au><au>Shuto, Satoshi</au><au>Fukuoka, Masayoshi</au><au>Kudoh, Takashi</au><au>Matsuda, Akira</au><au>Higashida, Haruhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amplification of depolarization‐induced and ryanodine‐sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP‐ribose and their antagonistic effects in NG108‐15 neuronal cells</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>2005-07</date><risdate>2005</risdate><volume>94</volume><issue>2</issue><spage>316</spage><epage>323</epage><pages>316-323</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><coden>JONRA9</coden><abstract>We synthesized analogs modified in the ribose unit (ribose linked to N1 of adenine) of cyclic ADP‐ribose (cADPR), a Ca2+‐mobilizing second messenger. The biological activities of these analogs were determined in NG108‐15 neuroblastoma × glioma hybrid cells that were pre‐loaded with fura‐2 acetoxymethylester and subjected to whole‐cell patch‐clamp. Application of the hydrolysis‐resistant cyclic ADP‐carbocyclic‐ribose (cADPcR) through patch pipettes potentiated elevation of the cytoplasmic free Ca2+ concentration ([Ca2+]i) at the depolarized membrane potential. The increase in [Ca2+]i evoked upon sustained membrane depolarization was significantly larger in cADPcR‐infused cells than in non‐infused cells and its degree was equivalent to or significantly greater than that induced by cADPR or β‐NAD+. 8‐chloro‐cADPcR and two inosine congeners (cyclic IDP‐carbocyclic‐ribose and 8‐bromo‐cyclic IDP‐carbocyclic‐ribose) did not induce effects similar to those of cADPcR or cADPR. Instead, 8‐chloro‐cADPcR together with cADPR or cADPcR caused inhibition of the depolarization‐induced [Ca2+]i increase as compared with either cADPR or cADPcR alone. These results demonstrated that our cADPR analogs have agonistic or antagonistic effects on the depolarization‐induced [Ca2+]i increase and suggested the presence of functional reciprocal coupling between ryanodine receptors and voltage‐activated Ca2+ channels via cADPR in mammalian neuronal cells.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15998283</pmid><doi>10.1111/j.1471-4159.2005.03197.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ageing, cell death Animals Biological and medical sciences Calcium Calcium - metabolism Calcium Channel Blockers - pharmacology Cell Line Cell physiology Cells Cyclic ADP-Ribose - analogs & derivatives Cyclic ADP-Ribose - chemical synthesis Cyclic ADP-Ribose - pharmacology cyclic ADP‐ribose Cytoplasm - drug effects Cytoplasm - metabolism cytoplasmic free Ca2+ concentration Dose-Response Relationship, Drug Drug Interactions Electric Stimulation - methods Fundamental and applied biological sciences. Psychology Fura-2 - metabolism Ions Medical sciences Membrane Potentials - drug effects Membrane Potentials - radiation effects Mice Molecular and cellular biology Neural Inhibition - drug effects Neural Inhibition - physiology Neuroblastoma neuroblastoma NG108‐15 cells Neurology Neurons Neurons - drug effects Neurons - physiology Neurons - radiation effects Nifedipine - pharmacology Patch-Clamp Techniques - methods Ruthenium - pharmacology Ryanodine - pharmacology ryanodine receptor Tumors of the nervous system. Phacomatoses β‐nicotinamide adenine dinucleotide |
| title | Amplification of depolarization‐induced and ryanodine‐sensitive cytosolic Ca2+ elevation by synthetic carbocyclic analogs of cyclic ADP‐ribose and their antagonistic effects in NG108‐15 neuronal cells |
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