Hippocalcin‐like 1 suppresses hepatocellular carcinoma progression by promoting p21Waf/Cip1 stabilization by activating the ERK1/2‐MAPK pathway

Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death. However, the underlying mechanism during hepatocarcinogenesis remains unclarified. Stable isotope labeling by amino acids in cell culture (SILAC) is a powerful quantitative strategy for proteome‐wide discovery of nove...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2016-03, Vol.63 (3), p.880-897
Hauptverfasser:	Zhang, Yonglong, Liu, Yanfeng, Duan, Jinlin, Yan, Haibo, Zhang, Jun, Zhang, Huilu, Fan, Qi, Luo, Feifei, Yan, Guoquan, Qiao, Ke, Liu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Cell culture Cell cycle Cell growth Cell proliferation Cyclin-dependent kinase inhibitor p21 Ectopic expression EF-hand Extracellular signal-regulated kinase GTP-binding protein Hepatocellular carcinoma Hepatology Kinases Liver cancer MAP kinase Nuclei Proteasomes Protein kinase Proteins Proteomes Therapeutic applications Tumor suppressor genes Ubiquitin-protein ligase
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