TAMARIND SUPPLEMENTATION AMELIORATES FLUORIDE-INDUCED GLUCOSE INTOLERANCE AND INSULIN RESISTANCE IN RATS
In addition to causing dental and skeletal fluorosis, exposure to high levels of the fluoride ion (F) can alter glucose homeostasis and lead to insulin resistance (IR). Tamarind can act as an antidiabetic agent and the present study was planned to investigate (i) the effect of F on IR and (ii) the p...
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| Veröffentlicht in: | Fluoride 2017-07, Vol.50 (3), p.314-323 |
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| creator | Validandi, Vakdevi Gourineni, Shankar Rao Dheeravath, Srinivas Nagalla, Balakrishna Khandare, Arjun L |
| description | In addition to causing dental and skeletal fluorosis, exposure to high levels of the fluoride ion (F) can alter glucose homeostasis and lead to insulin resistance (IR). Tamarind can act as an antidiabetic agent and the present study was planned to investigate (i) the effect of F on IR and (ii) the protective effect of tamarind (Tamarindus indica) fruit extract (TFE) supplementation on F-induced glucose intolerance and IR. For this purpose, Wistar National Institute of Nutrition (NIN) rats (n=18) were taken and randomly distributed into three groups: group I (control) were treated with normal water, group II (F) were treated with 100 ppm F water, and group III (F+TFE) were treated with 100 ppm F water + TFE (200 mg/kg body weight). After 6 months, an oral glucose tolerance test (OGTT) and the insulin profile were studied. The results of the study revealed that the homeostasis model assessment for insulin resistance (HOMA-IR) was unaffected by F but in the F+TFE treated group it was significantly decreased. A significant increase in the plasma glucose levels was observed in the F group at 30, 60, and 120 min (p |
| format | Article |
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Tamarind can act as an antidiabetic agent and the present study was planned to investigate (i) the effect of F on IR and (ii) the protective effect of tamarind (Tamarindus indica) fruit extract (TFE) supplementation on F-induced glucose intolerance and IR. For this purpose, Wistar National Institute of Nutrition (NIN) rats (n=18) were taken and randomly distributed into three groups: group I (control) were treated with normal water, group II (F) were treated with 100 ppm F water, and group III (F+TFE) were treated with 100 ppm F water + TFE (200 mg/kg body weight). After 6 months, an oral glucose tolerance test (OGTT) and the insulin profile were studied. The results of the study revealed that the homeostasis model assessment for insulin resistance (HOMA-IR) was unaffected by F but in the F+TFE treated group it was significantly decreased. A significant increase in the plasma glucose levels was observed in the F group at 30, 60, and 120 min (p<0.05, p<0.001, p<0.05, respectively), compared to both the control and the F+TFE groups. The plasma insulin levels were significantly higher (p<0.05) in the F group compared to the control group at 30 and 60 min during the OGTT. In the F+TFE group, with tamarind supplementation, the plasma insulin levels were (i) significantly lower (p<0.05) than in the F group, and (ii) were significantly higher (p<0.05) than in the control group at 30 min but not at 60 min. In the F group, the area under the curve (AUC) for glucose and insulin was significantly higher (p<0.05) as compared to the controls, while the F+TFE treatment restored the AUC for glucose and insulin to the control levels. The ratio of AUC glucose to AUC insulin was significantly lower (p<0.05) in both the F-treated and the F+TFE-treated rats compared to the control. In conclusion, the TFE supplementation ameliorated glucose intolerance and insulin resistance induced by F treatment in rats.]]></description><identifier>ISSN: 0015-4725</identifier><identifier>EISSN: 2253-4083</identifier><language>eng</language><publisher>Dunedin: International Society for Fluoride Research, Inc</publisher><subject>Glucose ; Insulin resistance ; Nutrition ; Rodents</subject><ispartof>Fluoride, 2017-07, Vol.50 (3), p.314-323</ispartof><rights>Copyright International Society for Fluoride Research, Inc. Jul-Sep 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Validandi, Vakdevi</creatorcontrib><creatorcontrib>Gourineni, Shankar Rao</creatorcontrib><creatorcontrib>Dheeravath, Srinivas</creatorcontrib><creatorcontrib>Nagalla, Balakrishna</creatorcontrib><creatorcontrib>Khandare, Arjun L</creatorcontrib><title>TAMARIND SUPPLEMENTATION AMELIORATES FLUORIDE-INDUCED GLUCOSE INTOLERANCE AND INSULIN RESISTANCE IN RATS</title><title>Fluoride</title><description><![CDATA[In addition to causing dental and skeletal fluorosis, exposure to high levels of the fluoride ion (F) can alter glucose homeostasis and lead to insulin resistance (IR). Tamarind can act as an antidiabetic agent and the present study was planned to investigate (i) the effect of F on IR and (ii) the protective effect of tamarind (Tamarindus indica) fruit extract (TFE) supplementation on F-induced glucose intolerance and IR. For this purpose, Wistar National Institute of Nutrition (NIN) rats (n=18) were taken and randomly distributed into three groups: group I (control) were treated with normal water, group II (F) were treated with 100 ppm F water, and group III (F+TFE) were treated with 100 ppm F water + TFE (200 mg/kg body weight). After 6 months, an oral glucose tolerance test (OGTT) and the insulin profile were studied. The results of the study revealed that the homeostasis model assessment for insulin resistance (HOMA-IR) was unaffected by F but in the F+TFE treated group it was significantly decreased. A significant increase in the plasma glucose levels was observed in the F group at 30, 60, and 120 min (p<0.05, p<0.001, p<0.05, respectively), compared to both the control and the F+TFE groups. The plasma insulin levels were significantly higher (p<0.05) in the F group compared to the control group at 30 and 60 min during the OGTT. In the F+TFE group, with tamarind supplementation, the plasma insulin levels were (i) significantly lower (p<0.05) than in the F group, and (ii) were significantly higher (p<0.05) than in the control group at 30 min but not at 60 min. In the F group, the area under the curve (AUC) for glucose and insulin was significantly higher (p<0.05) as compared to the controls, while the F+TFE treatment restored the AUC for glucose and insulin to the control levels. The ratio of AUC glucose to AUC insulin was significantly lower (p<0.05) in both the F-treated and the F+TFE-treated rats compared to the control. In conclusion, the TFE supplementation ameliorated glucose intolerance and insulin resistance induced by F treatment in rats.]]></description><subject>Glucose</subject><subject>Insulin resistance</subject><subject>Nutrition</subject><subject>Rodents</subject><issn>0015-4725</issn><issn>2253-4083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNotj8tqwzAUREVpoWnafxB0bbjSlfxYCltJBbIULHkdHD8ooTRpnPx_3cdqmGE4w9yRFecSEwE53pMVAJOJyLh8JE_zfATAgmGxIu9R1aoxrqKh3e2srrWLKhrvqKq1Nb5RUQe6sa1vTKWTpdiWuqJb25Y-aGpc9FY3ypWaqgViXGitcbTRwYT4G_84FcMzeZi6j3l8-dc1aTc6lm-J9VtTKpucWY7XBFMGos9hyA55ikU3dSBhksNQYM8QO9lPAvsJ0hSgE1PBxcAOfFzuZaLrOcM1ef3jni-nr9s4X_fH0-3yuUzuOaSYMyk54jeDpkqO</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Validandi, Vakdevi</creator><creator>Gourineni, Shankar Rao</creator><creator>Dheeravath, Srinivas</creator><creator>Nagalla, Balakrishna</creator><creator>Khandare, Arjun L</creator><general>International Society for Fluoride Research, Inc</general><scope>3V.</scope><scope>7XB</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20170701</creationdate><title>TAMARIND SUPPLEMENTATION AMELIORATES FLUORIDE-INDUCED GLUCOSE INTOLERANCE AND INSULIN RESISTANCE IN RATS</title><author>Validandi, Vakdevi ; Gourineni, Shankar Rao ; Dheeravath, Srinivas ; Nagalla, Balakrishna ; Khandare, Arjun L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p183t-36104c80d7b8639afa050f5dd93c133a5cf43cf06600a4f924d1b2e00174ac213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Glucose</topic><topic>Insulin resistance</topic><topic>Nutrition</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Validandi, Vakdevi</creatorcontrib><creatorcontrib>Gourineni, Shankar Rao</creatorcontrib><creatorcontrib>Dheeravath, Srinivas</creatorcontrib><creatorcontrib>Nagalla, Balakrishna</creatorcontrib><creatorcontrib>Khandare, Arjun L</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Australia & New Zealand Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Fluoride</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Validandi, Vakdevi</au><au>Gourineni, Shankar Rao</au><au>Dheeravath, Srinivas</au><au>Nagalla, Balakrishna</au><au>Khandare, Arjun L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TAMARIND SUPPLEMENTATION AMELIORATES FLUORIDE-INDUCED GLUCOSE INTOLERANCE AND INSULIN RESISTANCE IN RATS</atitle><jtitle>Fluoride</jtitle><date>2017-07-01</date><risdate>2017</risdate><volume>50</volume><issue>3</issue><spage>314</spage><epage>323</epage><pages>314-323</pages><issn>0015-4725</issn><eissn>2253-4083</eissn><abstract><![CDATA[In addition to causing dental and skeletal fluorosis, exposure to high levels of the fluoride ion (F) can alter glucose homeostasis and lead to insulin resistance (IR). Tamarind can act as an antidiabetic agent and the present study was planned to investigate (i) the effect of F on IR and (ii) the protective effect of tamarind (Tamarindus indica) fruit extract (TFE) supplementation on F-induced glucose intolerance and IR. For this purpose, Wistar National Institute of Nutrition (NIN) rats (n=18) were taken and randomly distributed into three groups: group I (control) were treated with normal water, group II (F) were treated with 100 ppm F water, and group III (F+TFE) were treated with 100 ppm F water + TFE (200 mg/kg body weight). After 6 months, an oral glucose tolerance test (OGTT) and the insulin profile were studied. The results of the study revealed that the homeostasis model assessment for insulin resistance (HOMA-IR) was unaffected by F but in the F+TFE treated group it was significantly decreased. A significant increase in the plasma glucose levels was observed in the F group at 30, 60, and 120 min (p<0.05, p<0.001, p<0.05, respectively), compared to both the control and the F+TFE groups. The plasma insulin levels were significantly higher (p<0.05) in the F group compared to the control group at 30 and 60 min during the OGTT. In the F+TFE group, with tamarind supplementation, the plasma insulin levels were (i) significantly lower (p<0.05) than in the F group, and (ii) were significantly higher (p<0.05) than in the control group at 30 min but not at 60 min. In the F group, the area under the curve (AUC) for glucose and insulin was significantly higher (p<0.05) as compared to the controls, while the F+TFE treatment restored the AUC for glucose and insulin to the control levels. The ratio of AUC glucose to AUC insulin was significantly lower (p<0.05) in both the F-treated and the F+TFE-treated rats compared to the control. In conclusion, the TFE supplementation ameliorated glucose intolerance and insulin resistance induced by F treatment in rats.]]></abstract><cop>Dunedin</cop><pub>International Society for Fluoride Research, Inc</pub><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Glucose Insulin resistance Nutrition Rodents |
| title | TAMARIND SUPPLEMENTATION AMELIORATES FLUORIDE-INDUCED GLUCOSE INTOLERANCE AND INSULIN RESISTANCE IN RATS |
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