HGF-mimic antibody administration to counteract doxorubicin cardiotoxicity

Objective: Doxorubicin (Doxo) is a highly effective and widely used anti-cancer drug. Unfortunately, its use is limited by its cumulative dose-dependent cardiotoxicity {CTX). Various molecular mechanisms are involved in Doxo-mediated CTX, including DNA damage, oxidative stress, apoptosis and dysregu...

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Veröffentlicht in:	Vascular pharmacology 2018-04, Vol.103-105, p.56-57
Hauptverfasser:	Gallo, S., Spilinga, M., Ferrauto, G., Di Gregorio, E., Bonzano, A., Comoglio, P.M., Crepaldi, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Anticancer properties Apoptosis Autophagy Biological effects Body weight c-Met protein Cancer Cardiomyocytes Cardiomyopathy Cardiotoxicity Cell death Chemotherapy Damage prevention Deoxyribonucleic acid DNA DNA damage DNA repair Doxorubicin Drugs Heart Hepatocyte growth factor Hypoxia Immunoglobulins Magnetic resonance imaging Mice Mitochondria Molecular chains Molecular modelling Mortality Muscle contraction Muscles Organs Oxidative stress Phagocytosis Thickening Weight measurement Weight reduction
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