5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity
New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-, para -acetyl-, and para -carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the...
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| Veröffentlicht in: | Russian journal of general chemistry 2018-05, Vol.88 (5), p.898-902 |
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| container_title | Russian journal of general chemistry |
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| creator | Galkina, I. V. Takhautdinova, G. L. Ivshin, K. A. Khayarov, Kh. R. Islamov, D. R. Bakhtiyarova, Yu. V. Yamalieva, L. N. Kataeva, O. N. Galkin, V. I. |
| description | New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-,
para
-acetyl-, and
para
-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. |
| doi_str_mv | 10.1134/S1070363218050092 |
| format | Article |
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para
-acetyl-, and
para
-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363218050092</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Amines ; Analysis ; Biological activity ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Chlorine ; Differential scanning calorimetry ; Heterocyclic compounds ; Microbiota (Symbiotic organisms) ; Organic chemistry ; Polychlorinated biphenyls ; Stability analysis ; Substitution reactions ; Thermal stability ; Thermogravimetry ; X-ray diffraction</subject><ispartof>Russian journal of general chemistry, 2018-05, Vol.88 (5), p.898-902</ispartof><rights>Pleiades Publishing, Ltd. 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Copyright Springer Nature B.V. 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-8769489b3c03110e00a7c4cdf7dcc515130e8a220732670d05c1a8d6b74f54c93</citedby><cites>FETCH-LOGICAL-c355t-8769489b3c03110e00a7c4cdf7dcc515130e8a220732670d05c1a8d6b74f54c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1070363218050092$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1070363218050092$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Galkina, I. V.</creatorcontrib><creatorcontrib>Takhautdinova, G. L.</creatorcontrib><creatorcontrib>Ivshin, K. A.</creatorcontrib><creatorcontrib>Khayarov, Kh. R.</creatorcontrib><creatorcontrib>Islamov, D. R.</creatorcontrib><creatorcontrib>Bakhtiyarova, Yu. V.</creatorcontrib><creatorcontrib>Yamalieva, L. N.</creatorcontrib><creatorcontrib>Kataeva, O. N.</creatorcontrib><creatorcontrib>Galkin, V. I.</creatorcontrib><title>5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-,
para
-acetyl-, and
para
-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.</description><subject>Amines</subject><subject>Analysis</subject><subject>Biological activity</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Chlorine</subject><subject>Differential scanning calorimetry</subject><subject>Heterocyclic compounds</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Organic chemistry</subject><subject>Polychlorinated biphenyls</subject><subject>Stability analysis</subject><subject>Substitution reactions</subject><subject>Thermal stability</subject><subject>Thermogravimetry</subject><subject>X-ray diffraction</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kE1PwzAMhisEEmPwA7hV4roOJ2mallsZn9IEh8K5ytJkZNqSkaSTxq8nU5E4IOSDLft9XltOkksEU4RIft0gYEAKglEJFKDCR8kIFVBmhFA4jnUcZ4f5aXLm_QoAARR4lHCa1RttbNb0Cx906IPs0jvp9I4HvZM-tSrNsxcdnFW941_cyJu02ZvwIb32k7QJrhehd3KSctOlt9qu7VILvk5rEQ102J8nJ4qvvbz4yePk_eH-bfaUzV8fn2f1PBOE0pCVrKjysloQAQQhkACciVx0inVCUEQRAVlyjIERXDDogArEy65YsFzRXFRknFwNvltnP3vpQ7uyvTNxZYuBVgUgBjSqpoNqydey1UbZ4LiI0cmNFtZIpWO_ZpiyCmFcRAANgHDWeydVu3V6w92-RdAeXt_-eX1k8MD4qDVL6X5P-R_6BiAXg9A</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Galkina, I. V.</creator><creator>Takhautdinova, G. L.</creator><creator>Ivshin, K. A.</creator><creator>Khayarov, Kh. R.</creator><creator>Islamov, D. R.</creator><creator>Bakhtiyarova, Yu. V.</creator><creator>Yamalieva, L. N.</creator><creator>Kataeva, O. N.</creator><creator>Galkin, V. I.</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20180501</creationdate><title>5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity</title><author>Galkina, I. V. ; Takhautdinova, G. L. ; Ivshin, K. A. ; Khayarov, Kh. R. ; Islamov, D. R. ; Bakhtiyarova, Yu. V. ; Yamalieva, L. N. ; Kataeva, O. N. ; Galkin, V. 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V.</creatorcontrib><creatorcontrib>Takhautdinova, G. L.</creatorcontrib><creatorcontrib>Ivshin, K. A.</creatorcontrib><creatorcontrib>Khayarov, Kh. R.</creatorcontrib><creatorcontrib>Islamov, D. R.</creatorcontrib><creatorcontrib>Bakhtiyarova, Yu. V.</creatorcontrib><creatorcontrib>Yamalieva, L. N.</creatorcontrib><creatorcontrib>Kataeva, O. N.</creatorcontrib><creatorcontrib>Galkin, V. I.</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galkina, I. V.</au><au>Takhautdinova, G. L.</au><au>Ivshin, K. A.</au><au>Khayarov, Kh. R.</au><au>Islamov, D. R.</au><au>Bakhtiyarova, Yu. V.</au><au>Yamalieva, L. N.</au><au>Kataeva, O. N.</au><au>Galkin, V. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2018-05-01</date><risdate>2018</risdate><volume>88</volume><issue>5</issue><spage>898</spage><epage>902</epage><pages>898-902</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>New amination reactions of 5-chloro-4-nitrobenzofurazane with different amines were studied. The reactions of 5-chloro-4-nitrobenzofurazane with 2,4,6-trichloro-,
para
-acetyl-, and
para
-carboxyethylanilines gave the products of aromatic nucleophilic substitution of the chlorine substituent in the nitrogenous heterocycle, the composition and structure of which was established by chemical, physical, and physicochemical methods and X-ray diffraction analysis. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG‒DSC). The synthesized compounds showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363218050092</doi><tpages>5</tpages></addata></record> |
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| subjects | Amines Analysis Biological activity Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Chlorine Differential scanning calorimetry Heterocyclic compounds Microbiota (Symbiotic organisms) Organic chemistry Polychlorinated biphenyls Stability analysis Substitution reactions Thermal stability Thermogravimetry X-ray diffraction |
| title | 5-Amino-Substituted Derivatives of 4-Nitrofurazane: Synthesis, Structure, and Biological Activity |
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