Polyketides from two Chaetomium species and their biological functions
Four new secondary metabolites, chaetosemins G-J ( 1−4 ), along with 11 known ones ( 5−15 ) were isolated from the culture of C. seminudum C208 and Chaetomium sp. C521. Their structures were determined by extensive NMR spectroscopic analyses. These metabolites were evaluated in vitro for antifungal,...
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| Veröffentlicht in: | Journal of antibiotics 2018-07, Vol.71 (7), p.677-681 |
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| creator | Li, He Liao, Zhong-Bin Tang, Dan Han, Wen-Bo Zhang, Qiang Gao, Jin-Ming |
| description | Four new secondary metabolites, chaetosemins G-J (
1−4
), along with 11 known ones (
5−15
) were isolated from the culture of
C. seminudum
C208 and
Chaetomium
sp. C521. Their structures were determined by extensive NMR spectroscopic analyses. These metabolites were evaluated in vitro for antifungal, antioxidant, toxicity, and α-glucosidase inhibitory activities. Chaetosemin J (
4
) and monaschromone (
5
) significantly inhibited the growth of four plant pathogenic fungi
Botrytis cinerea
,
Alternaria solani
,
Magnaporthe oryzae
, and
Gibberella saubinettii
with the minimum inhibitory concentrations (MIC) values ranging from 6.25 to 25.0 μM. Moreover, both epicoccone B (
11
) and flavipin (
14
) exhibited the DPPH free radical scavenging ability with IC
50
values of 10.8 and 7.2 μM, respectively, and had more potent α-glucosidase inhibition than the drug acarbose with IC
50
values of 27.3 and 33.8 μM, respectively. Monaschromone (
5
) might act as the lead compound of pesticide. |
| doi_str_mv | 10.1038/s41429-018-0047-x |
| format | Article |
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1−4
), along with 11 known ones (
5−15
) were isolated from the culture of
C. seminudum
C208 and
Chaetomium
sp. C521. Their structures were determined by extensive NMR spectroscopic analyses. These metabolites were evaluated in vitro for antifungal, antioxidant, toxicity, and α-glucosidase inhibitory activities. Chaetosemin J (
4
) and monaschromone (
5
) significantly inhibited the growth of four plant pathogenic fungi
Botrytis cinerea
,
Alternaria solani
,
Magnaporthe oryzae
, and
Gibberella saubinettii
with the minimum inhibitory concentrations (MIC) values ranging from 6.25 to 25.0 μM. Moreover, both epicoccone B (
11
) and flavipin (
14
) exhibited the DPPH free radical scavenging ability with IC
50
values of 10.8 and 7.2 μM, respectively, and had more potent α-glucosidase inhibition than the drug acarbose with IC
50
values of 27.3 and 33.8 μM, respectively. Monaschromone (
5
) might act as the lead compound of pesticide.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/s41429-018-0047-x</identifier><identifier>PMID: 29662118</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 101/6 ; 631/92/349 ; 639/638/92/349 ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Brief Communication ; Life Sciences ; Medicinal Chemistry ; Metabolites ; Microbiology ; Organic Chemistry ; Pesticides ; Secondary metabolites</subject><ispartof>Journal of antibiotics, 2018-07, Vol.71 (7), p.677-681</ispartof><rights>The Author(s) under exclusive licence to the Japan Antibiotics Research Association 2018</rights><rights>Copyright Nature Publishing Group Jul 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-d2a5362bdc0e6c1518ae4dda23a674c1228a2d8a84c5a40e0fbdc0f0573a66ab3</citedby><cites>FETCH-LOGICAL-c439t-d2a5362bdc0e6c1518ae4dda23a674c1228a2d8a84c5a40e0fbdc0f0573a66ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29662118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, He</creatorcontrib><creatorcontrib>Liao, Zhong-Bin</creatorcontrib><creatorcontrib>Tang, Dan</creatorcontrib><creatorcontrib>Han, Wen-Bo</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Gao, Jin-Ming</creatorcontrib><title>Polyketides from two Chaetomium species and their biological functions</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>Four new secondary metabolites, chaetosemins G-J (
1−4
), along with 11 known ones (
5−15
) were isolated from the culture of
C. seminudum
C208 and
Chaetomium
sp. C521. Their structures were determined by extensive NMR spectroscopic analyses. These metabolites were evaluated in vitro for antifungal, antioxidant, toxicity, and α-glucosidase inhibitory activities. Chaetosemin J (
4
) and monaschromone (
5
) significantly inhibited the growth of four plant pathogenic fungi
Botrytis cinerea
,
Alternaria solani
,
Magnaporthe oryzae
, and
Gibberella saubinettii
with the minimum inhibitory concentrations (MIC) values ranging from 6.25 to 25.0 μM. Moreover, both epicoccone B (
11
) and flavipin (
14
) exhibited the DPPH free radical scavenging ability with IC
50
values of 10.8 and 7.2 μM, respectively, and had more potent α-glucosidase inhibition than the drug acarbose with IC
50
values of 27.3 and 33.8 μM, respectively. Monaschromone (
5
) might act as the lead compound of pesticide.</description><subject>101/58</subject><subject>101/6</subject><subject>631/92/349</subject><subject>639/638/92/349</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Brief Communication</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Metabolites</subject><subject>Microbiology</subject><subject>Organic Chemistry</subject><subject>Pesticides</subject><subject>Secondary metabolites</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kD1PwzAURS0EoqXwA1hQJGbD80cSZ0QVBSQkGGC2HMdpXZK42Ilo_z2uUmBiesM99z7pIHRJ4IYAE7eBE04LDERgAJ7j7RGaEiEIJjwrjtEUgBIsBIUJOgthDcBylotTNKFFllFCxBQtXl2z-zC9rUxIau_apP9yyXylTO9aO7RJ2BhtY6a6KulXxvqktK5xS6tVk9RDp3vrunCOTmrVBHNxuDP0vrh_mz_i55eHp_ndM9acFT2uqEpZRstKg8k0SYlQhleVokxlOdeEUqFoJZTgOlUcDNR7tIY0j0CmSjZD1-PuxrvPwYRert3gu_hSUkiLOM4KESkyUtq7ELyp5cbbVvmdJCD35uRoTkZzcm9ObmPn6rA8lK2pfhs_qiJARyDEqFsa__f6_9Vv8d56Ig</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Li, He</creator><creator>Liao, Zhong-Bin</creator><creator>Tang, Dan</creator><creator>Han, Wen-Bo</creator><creator>Zhang, Qiang</creator><creator>Gao, Jin-Ming</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20180701</creationdate><title>Polyketides from two Chaetomium species and their biological functions</title><author>Li, He ; Liao, Zhong-Bin ; Tang, Dan ; Han, Wen-Bo ; Zhang, Qiang ; Gao, Jin-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d2a5362bdc0e6c1518ae4dda23a674c1228a2d8a84c5a40e0fbdc0f0573a66ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>101/58</topic><topic>101/6</topic><topic>631/92/349</topic><topic>639/638/92/349</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Brief Communication</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Metabolites</topic><topic>Microbiology</topic><topic>Organic Chemistry</topic><topic>Pesticides</topic><topic>Secondary metabolites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, He</creatorcontrib><creatorcontrib>Liao, Zhong-Bin</creatorcontrib><creatorcontrib>Tang, Dan</creatorcontrib><creatorcontrib>Han, Wen-Bo</creatorcontrib><creatorcontrib>Zhang, Qiang</creatorcontrib><creatorcontrib>Gao, Jin-Ming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, He</au><au>Liao, Zhong-Bin</au><au>Tang, Dan</au><au>Han, Wen-Bo</au><au>Zhang, Qiang</au><au>Gao, Jin-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyketides from two Chaetomium species and their biological functions</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>71</volume><issue>7</issue><spage>677</spage><epage>681</epage><pages>677-681</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>Four new secondary metabolites, chaetosemins G-J (
1−4
), along with 11 known ones (
5−15
) were isolated from the culture of
C. seminudum
C208 and
Chaetomium
sp. C521. Their structures were determined by extensive NMR spectroscopic analyses. These metabolites were evaluated in vitro for antifungal, antioxidant, toxicity, and α-glucosidase inhibitory activities. Chaetosemin J (
4
) and monaschromone (
5
) significantly inhibited the growth of four plant pathogenic fungi
Botrytis cinerea
,
Alternaria solani
,
Magnaporthe oryzae
, and
Gibberella saubinettii
with the minimum inhibitory concentrations (MIC) values ranging from 6.25 to 25.0 μM. Moreover, both epicoccone B (
11
) and flavipin (
14
) exhibited the DPPH free radical scavenging ability with IC
50
values of 10.8 and 7.2 μM, respectively, and had more potent α-glucosidase inhibition than the drug acarbose with IC
50
values of 27.3 and 33.8 μM, respectively. Monaschromone (
5
) might act as the lead compound of pesticide.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29662118</pmid><doi>10.1038/s41429-018-0047-x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 101/58 101/6 631/92/349 639/638/92/349 Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Life Sciences Medicinal Chemistry Metabolites Microbiology Organic Chemistry Pesticides Secondary metabolites |
| title | Polyketides from two Chaetomium species and their biological functions |
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