DNA UPTAKE IN BACTERIA
Natural competence is widespread among bacterial species. The mechanism of DNA uptake in both gram-positive and gram-negative bacteria is reviewed. The transformation pathways are discussed, with attention to the fate of donor DNA as it is processed by the competent cell. The proteins involved in me...
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| Veröffentlicht in: | Annual review of microbiology 1999-01, Vol.53 (1), p.217-244 |
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| creator | Dubnau, David |
| description | Natural competence is widespread among bacterial species. The mechanism of
DNA uptake in both gram-positive and gram-negative bacteria is reviewed. The
transformation pathways are discussed, with attention to the fate of donor DNA
as it is processed by the competent cell. The proteins involved in mediating
various steps in these pathways are described, and models for the
transformation mechanisms are presented. Uptake of DNA across the inner
membrane is probably similar in gram-positive and gram-negative bacteria, and
at least some of the required proteins are orthologs. The initial
transformation steps differ, as expected, from the presence of an outer
membrane only in the gram-negative organisms. The similarity of certain
essential competence proteins to those required for the assembly of type-4 pili
and for type-2 protein secretion is discussed. Finally several hypotheses for
the biological role of transformation are presented and evaluated. |
| doi_str_mv | 10.1146/annurev.micro.53.1.217 |
| format | Article |
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DNA uptake in both gram-positive and gram-negative bacteria is reviewed. The
transformation pathways are discussed, with attention to the fate of donor DNA
as it is processed by the competent cell. The proteins involved in mediating
various steps in these pathways are described, and models for the
transformation mechanisms are presented. Uptake of DNA across the inner
membrane is probably similar in gram-positive and gram-negative bacteria, and
at least some of the required proteins are orthologs. The initial
transformation steps differ, as expected, from the presence of an outer
membrane only in the gram-negative organisms. The similarity of certain
essential competence proteins to those required for the assembly of type-4 pili
and for type-2 protein secretion is discussed. Finally several hypotheses for
the biological role of transformation are presented and evaluated.</description><identifier>ISSN: 0066-4227</identifier><identifier>EISSN: 1545-3251</identifier><identifier>DOI: 10.1146/annurev.micro.53.1.217</identifier><identifier>PMID: 10547691</identifier><identifier>CODEN: ARMIAZ</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Adenosine Triphosphate - metabolism ; Bacteria ; Bacterial Proteins - metabolism ; Bacterial transformation ; Bacteriology ; Biological and medical sciences ; competence ; Deoxyribonucleic acid ; DNA ; DNA transport ; DNA, Bacterial - genetics ; DNA, Bacterial - metabolism ; Endodeoxyribonucleases - metabolism ; Fundamental and applied biological sciences. Psychology ; Genetic aspects ; Genetics ; Gram-Negative Bacteria - genetics ; Gram-Negative Bacteria - metabolism ; Gram-Positive Bacteria - genetics ; Gram-Positive Bacteria - metabolism ; Membrane Proteins ; Microbial genetics ; Microbiology ; Models, Biological ; pilus formation ; transformation ; Transformation, Bacterial ; type-2 secretion</subject><ispartof>Annual review of microbiology, 1999-01, Vol.53 (1), p.217-244</ispartof><rights>Copyright © 1999 by Annual Reviews. All rights reserved</rights><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1999 Annual Reviews, Inc.</rights><rights>Copyright Annual Reviews, Inc. 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a666t-bffff09cef48730336ee1c064ddc70273e98dc1e770ee18b0572600d33ac13203</citedby><cites>FETCH-LOGICAL-a666t-bffff09cef48730336ee1c064ddc70273e98dc1e770ee18b0572600d33ac13203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.53.1.217?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.micro.53.1.217$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1971466$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10547691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dubnau, David</creatorcontrib><title>DNA UPTAKE IN BACTERIA</title><title>Annual review of microbiology</title><addtitle>Annu Rev Microbiol</addtitle><description>Natural competence is widespread among bacterial species. The mechanism of
DNA uptake in both gram-positive and gram-negative bacteria is reviewed. The
transformation pathways are discussed, with attention to the fate of donor DNA
as it is processed by the competent cell. The proteins involved in mediating
various steps in these pathways are described, and models for the
transformation mechanisms are presented. Uptake of DNA across the inner
membrane is probably similar in gram-positive and gram-negative bacteria, and
at least some of the required proteins are orthologs. The initial
transformation steps differ, as expected, from the presence of an outer
membrane only in the gram-negative organisms. The similarity of certain
essential competence proteins to those required for the assembly of type-4 pili
and for type-2 protein secretion is discussed. Finally several hypotheses for
the biological role of transformation are presented and evaluated.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Bacteria</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bacterial transformation</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>competence</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA transport</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Bacterial - metabolism</subject><subject>Endodeoxyribonucleases - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic aspects</subject><subject>Genetics</subject><subject>Gram-Negative Bacteria - genetics</subject><subject>Gram-Negative Bacteria - metabolism</subject><subject>Gram-Positive Bacteria - genetics</subject><subject>Gram-Positive Bacteria - metabolism</subject><subject>Membrane Proteins</subject><subject>Microbial genetics</subject><subject>Microbiology</subject><subject>Models, Biological</subject><subject>pilus formation</subject><subject>transformation</subject><subject>Transformation, Bacterial</subject><subject>type-2 secretion</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0d-L00AQB_BFFK-evvp4FJF7MnH29wafYq1aPE6R3vOy3UyOHGnS2008_e_d2sIVKXTzsLD5zAzDl5ALCjmlQr13XTcG_JWvGx_6XPKc5ozqJ2RCpZAZZ5I-JRMApTLBmD4jL2K8AwChoXhOzihIoVVBJ-T1p-tyevNjWX6bTxfX04_lbDn_uShfkme1ayO-2t_n5ObzfDn7ml19_7KYlVeZU0oN2apOBwqPtTCaA-cKkXpQoqq8BqY5FqbyFLWG9MOsQGqmACrOnaecAT8nl7u-m9DfjxgHu26ix7Z1HfZjtKpgaRdDT0KqBXAjTYJv_oN3_Ri6tIRlII1RQhygW9eibbq6H4Lz2462lEYKoahI6N0RdIsdBtf2HdZNej7k2RGevgpTSMe82vkUYIwBa7sJzdqFP5aC3WZs9xnbfxlbyS21KeNUeLHfcFytsToo24WawNs9cNG7tg6u8018dIVO3VViH3ZsO8e1aVKDD4_s-HS7qWo7_B5OVZ_Y4S8Hi9dx</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Dubnau, David</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>R05</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>DNA UPTAKE IN BACTERIA</title><author>Dubnau, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a666t-bffff09cef48730336ee1c064ddc70273e98dc1e770ee18b0572600d33ac13203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Bacteria</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bacterial transformation</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>competence</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA transport</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Bacterial - metabolism</topic><topic>Endodeoxyribonucleases - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic aspects</topic><topic>Genetics</topic><topic>Gram-Negative Bacteria - genetics</topic><topic>Gram-Negative Bacteria - metabolism</topic><topic>Gram-Positive Bacteria - genetics</topic><topic>Gram-Positive Bacteria - metabolism</topic><topic>Membrane Proteins</topic><topic>Microbial genetics</topic><topic>Microbiology</topic><topic>Models, Biological</topic><topic>pilus formation</topic><topic>transformation</topic><topic>Transformation, Bacterial</topic><topic>type-2 secretion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dubnau, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Research Library China</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dubnau, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA UPTAKE IN BACTERIA</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>53</volume><issue>1</issue><spage>217</spage><epage>244</epage><pages>217-244</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><coden>ARMIAZ</coden><abstract>Natural competence is widespread among bacterial species. The mechanism of
DNA uptake in both gram-positive and gram-negative bacteria is reviewed. The
transformation pathways are discussed, with attention to the fate of donor DNA
as it is processed by the competent cell. The proteins involved in mediating
various steps in these pathways are described, and models for the
transformation mechanisms are presented. Uptake of DNA across the inner
membrane is probably similar in gram-positive and gram-negative bacteria, and
at least some of the required proteins are orthologs. The initial
transformation steps differ, as expected, from the presence of an outer
membrane only in the gram-negative organisms. The similarity of certain
essential competence proteins to those required for the assembly of type-4 pili
and for type-2 protein secretion is discussed. Finally several hypotheses for
the biological role of transformation are presented and evaluated.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>10547691</pmid><doi>10.1146/annurev.micro.53.1.217</doi><tpages>28</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4227 |
| ispartof | Annual review of microbiology, 1999-01, Vol.53 (1), p.217-244 |
| issn | 0066-4227 1545-3251 |
| language | eng |
| recordid | cdi_proquest_journals_205886448 |
| source | Annual Reviews; MEDLINE |
| subjects | Adenosine Triphosphate - metabolism Bacteria Bacterial Proteins - metabolism Bacterial transformation Bacteriology Biological and medical sciences competence Deoxyribonucleic acid DNA DNA transport DNA, Bacterial - genetics DNA, Bacterial - metabolism Endodeoxyribonucleases - metabolism Fundamental and applied biological sciences. Psychology Genetic aspects Genetics Gram-Negative Bacteria - genetics Gram-Negative Bacteria - metabolism Gram-Positive Bacteria - genetics Gram-Positive Bacteria - metabolism Membrane Proteins Microbial genetics Microbiology Models, Biological pilus formation transformation Transformation, Bacterial type-2 secretion |
| title | DNA UPTAKE IN BACTERIA |
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