Injectable nanoemulsions prepared by high pressure homogenization: processing, sterilization, and size evolution

Oil-in-water nanoemulsions are promising colloidal dispersions for the delivery of hydrophobic drugs. The use of polysorbate 80 as stabilizing agent in these formulations can improve the delivery of the drug to the brain, thanks to a tropism for apolipoproteins. The aim of this study was to formulat...

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Veröffentlicht in:	Applied nanoscience 2018-08, Vol.8 (6), p.1483-1491
Hauptverfasser:	Rosi Cappellani, Martina, Perinelli, Diego Romano, Pescosolido, Laura, Schoubben, Aurélie, Cespi, Marco, Cossi, Riccardo, Blasi, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated tests Autoclaving Brain Chemistry and Materials Science Colloiding Correlation analysis Dispersions Drug delivery systems Emulsions Evolution Filtration Fluorescence Fluorescent dyes Formulations Gaussian distribution Homogenization Materials Science Membrane Biology Nanochemistry Nanoemulsions Nanotechnology Nanotechnology and Microengineering Normal distribution Original Article Parameter sensitivity Particle size Pharmacology Polyoxyethylene sorbitan monooleate Real time Stability tests Sterilization Tropism
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