Anticonvulsant activity of aqueous extract of Leonotis leonurus
Water extract of Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections). L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% an...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2002-04, Vol.9 (3), p.217-223 |
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| creator | Bienvenu, E. Amabeoku, G.J. Eagles, P.K. Scott, G. Springfield, E.P. |
| description | Water extract of
Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections).
L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p < 0.05; Student's t-test) delayed pentylenetetrazole (90 mg/kg)-induced tonic seizures. Similarly, the same doses of
L. leonurusextract significantly (p < 0.05; Student's t-test) delayed the onset of tonic seizures produced by picrotoxin (8 mg/kg) and N-methyl-DL-aspartic acid (400 mg/kg). However, all the doses of aqueous extract of
L leonurus used did not alter the seizures induced by bicuculline (20 mg/kg) to any significant extent. The data suggest that the extract of
L. leonurus has anticonvulsant activity and may probably be acting through non-specific mechanisms, since it affects both gabaergic and glutaminergic systems. High performance liquid chromatography (HPLC) and phytochemical tests carried out respectively show a spectrum profile, characteristic of
L. leonurus and the presence of alkaloids, saponins and tannins in the extract. |
| doi_str_mv | 10.1078/0944-7113-00103 |
| format | Article |
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Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections).
L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p < 0.05; Student's t-test) delayed pentylenetetrazole (90 mg/kg)-induced tonic seizures. Similarly, the same doses of
L. leonurusextract significantly (p < 0.05; Student's t-test) delayed the onset of tonic seizures produced by picrotoxin (8 mg/kg) and N-methyl-DL-aspartic acid (400 mg/kg). However, all the doses of aqueous extract of
L leonurus used did not alter the seizures induced by bicuculline (20 mg/kg) to any significant extent. The data suggest that the extract of
L. leonurus has anticonvulsant activity and may probably be acting through non-specific mechanisms, since it affects both gabaergic and glutaminergic systems. High performance liquid chromatography (HPLC) and phytochemical tests carried out respectively show a spectrum profile, characteristic of
L. leonurus and the presence of alkaloids, saponins and tannins in the extract.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1078/0944-7113-00103</identifier><identifier>PMID: 12046862</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Animals ; anticonvulsant activity ; Anticonvulsants - administration & dosage ; Anticonvulsants - therapeutic use ; aqueous extract ; Bicuculline ; Chromatography, High Pressure Liquid ; Dose-Response Relationship, Drug ; gabaergic and glutaminergic ; Lamiaceae ; Leonotis leonurus ; Male ; mechanisms ; Mice ; N-Methylaspartate - analogs & derivatives ; Pentylenetetrazole ; Phytotherapy ; Picrotoxin ; Plant Extracts - administration & dosage ; Plant Extracts - therapeutic use ; seizures ; Seizures - chemically induced ; Seizures - prevention & control</subject><ispartof>Phytomedicine (Stuttgart), 2002-04, Vol.9 (3), p.217-223</ispartof><rights>2002 Urban & Fischer Verlag</rights><rights>COPYRIGHT 2002 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag Apr 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-3c165f562c4f4098dc1e034b681523192f5f88f8c66e5fc08a457e1cd2d2027b3</citedby><cites>FETCH-LOGICAL-c472t-3c165f562c4f4098dc1e034b681523192f5f88f8c66e5fc08a457e1cd2d2027b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/205560728?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12046862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bienvenu, E.</creatorcontrib><creatorcontrib>Amabeoku, G.J.</creatorcontrib><creatorcontrib>Eagles, P.K.</creatorcontrib><creatorcontrib>Scott, G.</creatorcontrib><creatorcontrib>Springfield, E.P.</creatorcontrib><title>Anticonvulsant activity of aqueous extract of Leonotis leonurus</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Water extract of
Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections).
L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p < 0.05; Student's t-test) delayed pentylenetetrazole (90 mg/kg)-induced tonic seizures. Similarly, the same doses of
L. leonurusextract significantly (p < 0.05; Student's t-test) delayed the onset of tonic seizures produced by picrotoxin (8 mg/kg) and N-methyl-DL-aspartic acid (400 mg/kg). However, all the doses of aqueous extract of
L leonurus used did not alter the seizures induced by bicuculline (20 mg/kg) to any significant extent. The data suggest that the extract of
L. leonurus has anticonvulsant activity and may probably be acting through non-specific mechanisms, since it affects both gabaergic and glutaminergic systems. High performance liquid chromatography (HPLC) and phytochemical tests carried out respectively show a spectrum profile, characteristic of
L. leonurus and the presence of alkaloids, saponins and tannins in the extract.</description><subject>Animals</subject><subject>anticonvulsant activity</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Anticonvulsants - therapeutic use</subject><subject>aqueous extract</subject><subject>Bicuculline</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dose-Response Relationship, Drug</subject><subject>gabaergic and glutaminergic</subject><subject>Lamiaceae</subject><subject>Leonotis leonurus</subject><subject>Male</subject><subject>mechanisms</subject><subject>Mice</subject><subject>N-Methylaspartate - analogs & derivatives</subject><subject>Pentylenetetrazole</subject><subject>Phytotherapy</subject><subject>Picrotoxin</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - therapeutic use</subject><subject>seizures</subject><subject>Seizures - chemically induced</subject><subject>Seizures - prevention & control</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc1LBCEYxiWK2j7O3WLo3JQ66jinWKIvWOhS0E1mndcwZrXUWeq_z2mXCio8KM_78_16EDok-JTgWp7hhrGyJqQqMSa42kATIogsccMfN9HkK7qDdmN8zghraryNdgjFTEhBJ-h86pLV3i2HPrYuFa1OdmnTe-FN0b4O4IdYwFsKWR-lGXjnk41Fnx9DGOI-2jJtH-Fgfe-hh6vL-4ubcnZ3fXsxnZWa1TSVlSaCGy6oZobhRnaaAK7YXEjCaUUaariR0kgtBHCjsWwZr4HojnYU03pe7aHjVd6X4HNbMalnPwSXSyqKORe4pvIbemp7UNYZPza-sFGraUM5Y7KqM3TyB_QEDkLbewfGZvknXv6B59PBYlzcb_5sxevgYwxg1Euwiza8K4LV6JkaXVGjK-rTs_zjaD3aMF9A982vTcpAswIgL3hpIaioLTgNnQ2gk-q8_Tf5B8LNoSQ</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Bienvenu, E.</creator><creator>Amabeoku, G.J.</creator><creator>Eagles, P.K.</creator><creator>Scott, G.</creator><creator>Springfield, E.P.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20020401</creationdate><title>Anticonvulsant activity of aqueous extract of Leonotis leonurus</title><author>Bienvenu, E. ; Amabeoku, G.J. ; Eagles, P.K. ; Scott, G. ; Springfield, E.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-3c165f562c4f4098dc1e034b681523192f5f88f8c66e5fc08a457e1cd2d2027b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>anticonvulsant activity</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Anticonvulsants - therapeutic use</topic><topic>aqueous extract</topic><topic>Bicuculline</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dose-Response Relationship, Drug</topic><topic>gabaergic and glutaminergic</topic><topic>Lamiaceae</topic><topic>Leonotis leonurus</topic><topic>Male</topic><topic>mechanisms</topic><topic>Mice</topic><topic>N-Methylaspartate - analogs & derivatives</topic><topic>Pentylenetetrazole</topic><topic>Phytotherapy</topic><topic>Picrotoxin</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - therapeutic use</topic><topic>seizures</topic><topic>Seizures - chemically induced</topic><topic>Seizures - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bienvenu, E.</creatorcontrib><creatorcontrib>Amabeoku, G.J.</creatorcontrib><creatorcontrib>Eagles, P.K.</creatorcontrib><creatorcontrib>Scott, G.</creatorcontrib><creatorcontrib>Springfield, E.P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bienvenu, E.</au><au>Amabeoku, G.J.</au><au>Eagles, P.K.</au><au>Scott, G.</au><au>Springfield, E.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticonvulsant activity of aqueous extract of Leonotis leonurus</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>9</volume><issue>3</issue><spage>217</spage><epage>223</epage><pages>217-223</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Water extract of
Leonotis leonurus was tested for anticonvulsant activity against seizures produced in mice by pentylenetetrazole, picrotoxin, bicuculline and N-methyl-DL-aspartic acid (intraperitoneal injections).
L. leonurus extract in the doses of 200 and 400 mg/kg respectively protected 37.5% and 50% of animals used and significantly (p < 0.05; Student's t-test) delayed pentylenetetrazole (90 mg/kg)-induced tonic seizures. Similarly, the same doses of
L. leonurusextract significantly (p < 0.05; Student's t-test) delayed the onset of tonic seizures produced by picrotoxin (8 mg/kg) and N-methyl-DL-aspartic acid (400 mg/kg). However, all the doses of aqueous extract of
L leonurus used did not alter the seizures induced by bicuculline (20 mg/kg) to any significant extent. The data suggest that the extract of
L. leonurus has anticonvulsant activity and may probably be acting through non-specific mechanisms, since it affects both gabaergic and glutaminergic systems. High performance liquid chromatography (HPLC) and phytochemical tests carried out respectively show a spectrum profile, characteristic of
L. leonurus and the presence of alkaloids, saponins and tannins in the extract.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>12046862</pmid><doi>10.1078/0944-7113-00103</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals anticonvulsant activity Anticonvulsants - administration & dosage Anticonvulsants - therapeutic use aqueous extract Bicuculline Chromatography, High Pressure Liquid Dose-Response Relationship, Drug gabaergic and glutaminergic Lamiaceae Leonotis leonurus Male mechanisms Mice N-Methylaspartate - analogs & derivatives Pentylenetetrazole Phytotherapy Picrotoxin Plant Extracts - administration & dosage Plant Extracts - therapeutic use seizures Seizures - chemically induced Seizures - prevention & control |
| title | Anticonvulsant activity of aqueous extract of Leonotis leonurus |
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