Anti-diabetic potential of Barleria lupulina extract in rats
We have undertaken a study to evaluate the anti-hyperglycemic effect of a methanol extract of aerial parts of Barleria lupulina Lindl. (Acanthaceae) in streptozotocin-diabetic rats, based on folkloric reports its use as an anti-diabetic agent. The extract exerted significant (p < 0.05) anti-hyper...
Gespeichert in:
| Veröffentlicht in: | Phytomedicine (Stuttgart) 2004-02, Vol.11 (2), p.202-205 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 205 |
|---|---|
| container_issue | 2 |
| container_start_page | 202 |
| container_title | Phytomedicine (Stuttgart) |
| container_volume | 11 |
| creator | Suba, V. Murugesan, T. Arunachalam, G. Mandal, S.C. Saha, B.P. |
| description | We have undertaken a study to evaluate the anti-hyperglycemic effect of a methanol extract of aerial parts of
Barleria lupulina Lindl. (Acanthaceae) in streptozotocin-diabetic rats, based on folkloric reports its use as an anti-diabetic agent.
The extract exerted significant (p < 0.05) anti-hyperglycemic efficacy at all levels tested from 4 h after its administration, as compared with the control group, and the effect was also prolonged up to 12 h. The extract at doses of 200 mg kg
–1 body wt. and above exhibited a maximum activity (p < 0.001) at 12 h after administration. The most significant activity (15.35% blood glucose reduction) was observed for the group administered 300 mg kg
–1 body wt. at 12 h after administration, while the standard drug glibenclamide (10 mg/kg
–1 body wt.) showed an 18.80% reduction of blood glucose at the same time interval.
Based on our current results, it appears that the methanol extract of aerial parts of
Barleria lupulina Lindl. shows a pronounced blood-glucose-lowering potential in streptozotocin hyperglycemic rats, and is thus provided with a pharmacological support of the folklore claims of anti-diabetic activity. |
| doi_str_mv | 10.1078/0944-7113-00316 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_205553858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A115835560</galeid><els_id>S0944711304703177</els_id><sourcerecordid>A115835560</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-b97fc7e622b327774004d57c5cf10ca0ea4cc7f94cff97e188f4eed3ae9c6b433</originalsourceid><addsrcrecordid>eNp1kUFr3DAQhUVIabZpz701JncnI0uyLMhlE5q2EOihDfQmZHm0KHitjSSH5t9XWy_pJWUOAzPfmxneEPKRwgUF2V2C4ryWlLIagNH2iKxoS7salPh1TFYv3RPyLqUHAMqVhLfkhAqQQCVbkav1lH09eNNj9rbahYylYMYquOraxBGjN9U47-bRT6bC3zkamys_VdHk9J68cWZM-OGQT8n97eefN1_ru-9fvt2s72ormMx1r6SzEtum6VkjpeQAfBDSCusoWANouLXSKW6dUxJp1zmOODCDyrY9Z-yUnC9zdzE8zpiyfghznMpK3YAQgnWiK1C9QBszovaTC_tbNzhhNGOY0PlSXlNaUCFaKPzFK3yJAbfeviq4XAQ2hpQiOr2Lfmvis6ag99_Qe7_13m_99xtF8elw99xvcfjHH-wvwNkCOBO02USf9P2PBigDCiBbJQqhFgKLv08eo07W42Rx8BFt1kPw_13_B6XXnp0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205553858</pqid></control><display><type>article</type><title>Anti-diabetic potential of Barleria lupulina extract in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Suba, V. ; Murugesan, T. ; Arunachalam, G. ; Mandal, S.C. ; Saha, B.P.</creator><creatorcontrib>Suba, V. ; Murugesan, T. ; Arunachalam, G. ; Mandal, S.C. ; Saha, B.P.</creatorcontrib><description>We have undertaken a study to evaluate the anti-hyperglycemic effect of a methanol extract of aerial parts of
Barleria lupulina Lindl. (Acanthaceae) in streptozotocin-diabetic rats, based on folkloric reports its use as an anti-diabetic agent.
The extract exerted significant (p < 0.05) anti-hyperglycemic efficacy at all levels tested from 4 h after its administration, as compared with the control group, and the effect was also prolonged up to 12 h. The extract at doses of 200 mg kg
–1 body wt. and above exhibited a maximum activity (p < 0.001) at 12 h after administration. The most significant activity (15.35% blood glucose reduction) was observed for the group administered 300 mg kg
–1 body wt. at 12 h after administration, while the standard drug glibenclamide (10 mg/kg
–1 body wt.) showed an 18.80% reduction of blood glucose at the same time interval.
Based on our current results, it appears that the methanol extract of aerial parts of
Barleria lupulina Lindl. shows a pronounced blood-glucose-lowering potential in streptozotocin hyperglycemic rats, and is thus provided with a pharmacological support of the folklore claims of anti-diabetic activity.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1078/0944-7113-00316</identifier><identifier>PMID: 15070173</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Acanthaceae ; Animals ; anti-diabetic ; Barleria lupulina ; Blood Glucose - drug effects ; Case studies ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - prevention & control ; Dose-Response Relationship, Drug ; Health aspects ; Hypoglycemia ; Hypoglycemic agents ; Hypoglycemic Agents - administration & dosage ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Male ; Methanol ; methanol extract (MEBL) ; Phytotherapy ; Plant Components, Aerial ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Rats ; Rats, Wistar ; Rattus ; Streptozocin</subject><ispartof>Phytomedicine (Stuttgart), 2004-02, Vol.11 (2), p.202-205</ispartof><rights>2004 Urban & Fischer Verlag</rights><rights>COPYRIGHT 2004 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-b97fc7e622b327774004d57c5cf10ca0ea4cc7f94cff97e188f4eed3ae9c6b433</citedby><cites>FETCH-LOGICAL-c537t-b97fc7e622b327774004d57c5cf10ca0ea4cc7f94cff97e188f4eed3ae9c6b433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711304703177$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15070173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suba, V.</creatorcontrib><creatorcontrib>Murugesan, T.</creatorcontrib><creatorcontrib>Arunachalam, G.</creatorcontrib><creatorcontrib>Mandal, S.C.</creatorcontrib><creatorcontrib>Saha, B.P.</creatorcontrib><title>Anti-diabetic potential of Barleria lupulina extract in rats</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>We have undertaken a study to evaluate the anti-hyperglycemic effect of a methanol extract of aerial parts of
Barleria lupulina Lindl. (Acanthaceae) in streptozotocin-diabetic rats, based on folkloric reports its use as an anti-diabetic agent.
The extract exerted significant (p < 0.05) anti-hyperglycemic efficacy at all levels tested from 4 h after its administration, as compared with the control group, and the effect was also prolonged up to 12 h. The extract at doses of 200 mg kg
–1 body wt. and above exhibited a maximum activity (p < 0.001) at 12 h after administration. The most significant activity (15.35% blood glucose reduction) was observed for the group administered 300 mg kg
–1 body wt. at 12 h after administration, while the standard drug glibenclamide (10 mg/kg
–1 body wt.) showed an 18.80% reduction of blood glucose at the same time interval.
Based on our current results, it appears that the methanol extract of aerial parts of
Barleria lupulina Lindl. shows a pronounced blood-glucose-lowering potential in streptozotocin hyperglycemic rats, and is thus provided with a pharmacological support of the folklore claims of anti-diabetic activity.</description><subject>Acanthaceae</subject><subject>Animals</subject><subject>anti-diabetic</subject><subject>Barleria lupulina</subject><subject>Blood Glucose - drug effects</subject><subject>Case studies</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Health aspects</subject><subject>Hypoglycemia</subject><subject>Hypoglycemic agents</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Male</subject><subject>Methanol</subject><subject>methanol extract (MEBL)</subject><subject>Phytotherapy</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rattus</subject><subject>Streptozocin</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUFr3DAQhUVIabZpz701JncnI0uyLMhlE5q2EOihDfQmZHm0KHitjSSH5t9XWy_pJWUOAzPfmxneEPKRwgUF2V2C4ryWlLIagNH2iKxoS7salPh1TFYv3RPyLqUHAMqVhLfkhAqQQCVbkav1lH09eNNj9rbahYylYMYquOraxBGjN9U47-bRT6bC3zkamys_VdHk9J68cWZM-OGQT8n97eefN1_ru-9fvt2s72ormMx1r6SzEtum6VkjpeQAfBDSCusoWANouLXSKW6dUxJp1zmOODCDyrY9Z-yUnC9zdzE8zpiyfghznMpK3YAQgnWiK1C9QBszovaTC_tbNzhhNGOY0PlSXlNaUCFaKPzFK3yJAbfeviq4XAQ2hpQiOr2Lfmvis6ag99_Qe7_13m_99xtF8elw99xvcfjHH-wvwNkCOBO02USf9P2PBigDCiBbJQqhFgKLv08eo07W42Rx8BFt1kPw_13_B6XXnp0</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Suba, V.</creator><creator>Murugesan, T.</creator><creator>Arunachalam, G.</creator><creator>Mandal, S.C.</creator><creator>Saha, B.P.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><general>Elsevier Science Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20040201</creationdate><title>Anti-diabetic potential of Barleria lupulina extract in rats</title><author>Suba, V. ; Murugesan, T. ; Arunachalam, G. ; Mandal, S.C. ; Saha, B.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-b97fc7e622b327774004d57c5cf10ca0ea4cc7f94cff97e188f4eed3ae9c6b433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acanthaceae</topic><topic>Animals</topic><topic>anti-diabetic</topic><topic>Barleria lupulina</topic><topic>Blood Glucose - drug effects</topic><topic>Case studies</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Health aspects</topic><topic>Hypoglycemia</topic><topic>Hypoglycemic agents</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Male</topic><topic>Methanol</topic><topic>methanol extract (MEBL)</topic><topic>Phytotherapy</topic><topic>Plant Components, Aerial</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rattus</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suba, V.</creatorcontrib><creatorcontrib>Murugesan, T.</creatorcontrib><creatorcontrib>Arunachalam, G.</creatorcontrib><creatorcontrib>Mandal, S.C.</creatorcontrib><creatorcontrib>Saha, B.P.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suba, V.</au><au>Murugesan, T.</au><au>Arunachalam, G.</au><au>Mandal, S.C.</au><au>Saha, B.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-diabetic potential of Barleria lupulina extract in rats</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>11</volume><issue>2</issue><spage>202</spage><epage>205</epage><pages>202-205</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>We have undertaken a study to evaluate the anti-hyperglycemic effect of a methanol extract of aerial parts of
Barleria lupulina Lindl. (Acanthaceae) in streptozotocin-diabetic rats, based on folkloric reports its use as an anti-diabetic agent.
The extract exerted significant (p < 0.05) anti-hyperglycemic efficacy at all levels tested from 4 h after its administration, as compared with the control group, and the effect was also prolonged up to 12 h. The extract at doses of 200 mg kg
–1 body wt. and above exhibited a maximum activity (p < 0.001) at 12 h after administration. The most significant activity (15.35% blood glucose reduction) was observed for the group administered 300 mg kg
–1 body wt. at 12 h after administration, while the standard drug glibenclamide (10 mg/kg
–1 body wt.) showed an 18.80% reduction of blood glucose at the same time interval.
Based on our current results, it appears that the methanol extract of aerial parts of
Barleria lupulina Lindl. shows a pronounced blood-glucose-lowering potential in streptozotocin hyperglycemic rats, and is thus provided with a pharmacological support of the folklore claims of anti-diabetic activity.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>15070173</pmid><doi>10.1078/0944-7113-00316</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2004-02, Vol.11 (2), p.202-205 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_journals_205553858 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acanthaceae Animals anti-diabetic Barleria lupulina Blood Glucose - drug effects Case studies Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - prevention & control Dose-Response Relationship, Drug Health aspects Hypoglycemia Hypoglycemic agents Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Male Methanol methanol extract (MEBL) Phytotherapy Plant Components, Aerial Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Rattus Streptozocin |
| title | Anti-diabetic potential of Barleria lupulina extract in rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T01%3A55%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-diabetic%20potential%20of%20Barleria%20lupulina%20extract%20in%20rats&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Suba,%20V.&rft.date=2004-02-01&rft.volume=11&rft.issue=2&rft.spage=202&rft.epage=205&rft.pages=202-205&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1078/0944-7113-00316&rft_dat=%3Cgale_proqu%3EA115835560%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205553858&rft_id=info:pmid/15070173&rft_galeid=A115835560&rft_els_id=S0944711304703177&rfr_iscdi=true |