Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes

Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes

A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5‐chlorothiophene‐2‐carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under...

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Veröffentlicht in:Journal of heterocyclic chemistry 2018-06, Vol.55 (6), p.1410-1418
Hauptverfasser: Thatha, Sreenivasulu, Ummadi, Nagarjuna, Venkatapuram, Padmavathi, Adivireddy, Padmaja
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Sprache:eng
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Amines
Antioxidants
Carbonyls
Chemical synthesis
Phosgene
Thiophenes
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container_end_page 1418
container_issue 6
container_start_page 1410
container_title Journal of heterocyclic chemistry
container_volume 55
creator Thatha, Sreenivasulu
Ummadi, Nagarjuna
Venkatapuram, Padmavathi
Adivireddy, Padmaja
description A new class of amido linked azolyl thiophenes was prepared from the synthetic intermediates azolyl amines and 5‐chlorothiophene‐2‐carbonyl chloride adopting conventional and ultrasonication methodologies. It was observed that the reaction took place in shorter reaction times with higher yields under ultrasonication. The structures of the synthesized compounds were characterized by spectral parameters and also tested for antioxidant activity. Among all the tested compounds, methoxy substituted oxazolyl thiophene carboxamide (8c) displayed promising antioxidant activity. Besides, the electron donating groups on the phenyl ring enhanced the antioxidant activity when compared with the electron withdrawing groups.
doi_str_mv 10.1002/jhet.3177
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subjects Amines
Antioxidants
Carbonyls
Chemical synthesis
Phosgene
Thiophenes
title Synthesis, Characterization, and Antioxidant Activity of a New Class of Amido linked Azolyl Thiophenes
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