Upconversion nanocrystal 'armoured' silica fibres with superior photoluminescence for miRNA detection

Upconversion nanocrystal 'armoured' silica fibres with superior photoluminescence for miRNA detection

We have fabricated a flexible membrane, consisting of SiO 2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted with molecular beacons to produce a biosensor suitable for the detection of specific microRNA and with app...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (49), p.6324-6327
Hauptverfasser: Wang, Gang, Fu, Yike, Ren, Zhaohui, Huang, Jie, Best, Serena, Li, Xiang, Han, Gaorong
Format: Artikel
Sprache:eng
Schlagworte:
Beacons
Biosensors
Molecular chains
Nanofibers
Photoluminescence
Ribonucleic acid
RNA
Silicon dioxide
Upconversion
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Zusammenfassung:We have fabricated a flexible membrane, consisting of SiO 2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted with molecular beacons to produce a biosensor suitable for the detection of specific microRNA and with applications in early cancer detection and point-of-care diagnosis. A FRET biosensor, based on silica nanofibres armoured with NaYF 4 :Yb,Er upcoversion nanoparticles (SiO 2 @UCNP), offers a simple and quantitative methodology for cancer biomarker (miRNA-21) detection.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03480j