PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS
50 cases of cancer of the breast (diagnosed between 1962 and 1966) were studied retrospectively. An enzyme-bridge immunoperoxidase technique was used to demonstrate that so-called pregnancy-specific proteins were detectable in the cytoplasm of the tumour cells. Of the proteins studied, pregnancy-spe...
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1976-08, Vol.308 (7980), p.279-282 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 282 |
|---|---|
| container_issue | 7980 |
| container_start_page | 279 |
| container_title | The Lancet (British edition) |
| container_volume | 308 |
| creator | Horne, C.H.W Reid, I.N Milne, G.D |
| description | 50 cases of cancer of the breast (diagnosed between 1962 and 1966) were studied retrospectively. An enzyme-bridge immunoperoxidase technique was used to demonstrate that so-called pregnancy-specific proteins were detectable in the cytoplasm of the tumour cells. Of the proteins studied, pregnancy-specific β1-glycoprotein was present in 76% of cases, placental lactogen in 82%, and chorionic gonadotrophin in 60%. Those women with cancers negative for pregnancy-specific β1-glycoprotein and placental lactogen had significantly longer survival-time compared with those whose cancers stained for these proteins. Pregnancy-specific β1—glycoprotein appears to be the best indicator of prognosis. A prospective study is needed to determine wether those patients requiring adjuvant chemotherapy after mastectomy can be identified by staining tumour tissue for pregnancy-specific β1-glyco- protein by the enzyme-bridge technique. |
| doi_str_mv | 10.1016/S0140-6736(76)90731-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2054773312</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673676907315</els_id><sourcerecordid>2054773312</sourcerecordid><originalsourceid>FETCH-LOGICAL-c250t-8510a6c11186ba9f8a5ae0a8f86637f807052eb7703299a39e7579eafd4fab3c3</originalsourceid><addsrcrecordid>eNqFUMFKw0AUXETBWv0EIeBFD9G32exucpIY07hQkpCkYPGwbNMNpGhbN63g37tpxaun93gzb4YZhK4x3GPA7KEC7IPLOGG3nN2FwAl26QkaYZ_7LvX56yka_VHO0UXfrwDAZ0BH6K0o8zTLq1rETiXSTExEHGVx4uQTR2RRYeGiFFGdOHZ7nsW1yLMBK8okzSxxPtzrRGSV8zR3nsokqmrnoFBWl-isVe-9vvqdYzSbJHX84k7z1LpM3cajsHMDikGxBmMcsIUK20BRpUEFbcAY4W0AHKinF5wD8cJQkVBzykOt2qXfqgVpyBjdHHW3ZvO51_1OrjZ7s7aW0gObnxOCPcuiR1ZjNn1vdCu3pvtQ5ltikEOP8tCjHEqSnMlDj5Lav8fjn7YRvjptZN90et3oZWd0s5PLTfePwg8sY3GD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2054773312</pqid></control><display><type>article</type><title>PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS</title><source>Elsevier ScienceDirect Journals</source><creator>Horne, C.H.W ; Reid, I.N ; Milne, G.D</creator><creatorcontrib>Horne, C.H.W ; Reid, I.N ; Milne, G.D</creatorcontrib><description>50 cases of cancer of the breast (diagnosed between 1962 and 1966) were studied retrospectively. An enzyme-bridge immunoperoxidase technique was used to demonstrate that so-called pregnancy-specific proteins were detectable in the cytoplasm of the tumour cells. Of the proteins studied, pregnancy-specific β1-glycoprotein was present in 76% of cases, placental lactogen in 82%, and chorionic gonadotrophin in 60%. Those women with cancers negative for pregnancy-specific β1-glycoprotein and placental lactogen had significantly longer survival-time compared with those whose cancers stained for these proteins. Pregnancy-specific β1—glycoprotein appears to be the best indicator of prognosis. A prospective study is needed to determine wether those patients requiring adjuvant chemotherapy after mastectomy can be identified by staining tumour tissue for pregnancy-specific β1-glyco- protein by the enzyme-bridge technique.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(76)90731-5</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Breast cancer ; Cancer ; Chemotherapy ; Cytoplasm ; Enzymes ; Glycoproteins ; Medical prognosis ; Pituitary (anterior) ; Placenta ; Pregnancy ; Proteins ; Tumors</subject><ispartof>The Lancet (British edition), 1976-08, Vol.308 (7980), p.279-282</ispartof><rights>1976</rights><rights>Copyright Elsevier Limited Aug 7, 1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c250t-8510a6c11186ba9f8a5ae0a8f86637f807052eb7703299a39e7579eafd4fab3c3</citedby><cites>FETCH-LOGICAL-c250t-8510a6c11186ba9f8a5ae0a8f86637f807052eb7703299a39e7579eafd4fab3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673676907315$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Horne, C.H.W</creatorcontrib><creatorcontrib>Reid, I.N</creatorcontrib><creatorcontrib>Milne, G.D</creatorcontrib><title>PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS</title><title>The Lancet (British edition)</title><description>50 cases of cancer of the breast (diagnosed between 1962 and 1966) were studied retrospectively. An enzyme-bridge immunoperoxidase technique was used to demonstrate that so-called pregnancy-specific proteins were detectable in the cytoplasm of the tumour cells. Of the proteins studied, pregnancy-specific β1-glycoprotein was present in 76% of cases, placental lactogen in 82%, and chorionic gonadotrophin in 60%. Those women with cancers negative for pregnancy-specific β1-glycoprotein and placental lactogen had significantly longer survival-time compared with those whose cancers stained for these proteins. Pregnancy-specific β1—glycoprotein appears to be the best indicator of prognosis. A prospective study is needed to determine wether those patients requiring adjuvant chemotherapy after mastectomy can be identified by staining tumour tissue for pregnancy-specific β1-glyco- protein by the enzyme-bridge technique.</description><subject>Breast cancer</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Cytoplasm</subject><subject>Enzymes</subject><subject>Glycoproteins</subject><subject>Medical prognosis</subject><subject>Pituitary (anterior)</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Tumors</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><recordid>eNqFUMFKw0AUXETBWv0EIeBFD9G32exucpIY07hQkpCkYPGwbNMNpGhbN63g37tpxaun93gzb4YZhK4x3GPA7KEC7IPLOGG3nN2FwAl26QkaYZ_7LvX56yka_VHO0UXfrwDAZ0BH6K0o8zTLq1rETiXSTExEHGVx4uQTR2RRYeGiFFGdOHZ7nsW1yLMBK8okzSxxPtzrRGSV8zR3nsokqmrnoFBWl-isVe-9vvqdYzSbJHX84k7z1LpM3cajsHMDikGxBmMcsIUK20BRpUEFbcAY4W0AHKinF5wD8cJQkVBzykOt2qXfqgVpyBjdHHW3ZvO51_1OrjZ7s7aW0gObnxOCPcuiR1ZjNn1vdCu3pvtQ5ltikEOP8tCjHEqSnMlDj5Lav8fjn7YRvjptZN90et3oZWd0s5PLTfePwg8sY3GD</recordid><startdate>19760807</startdate><enddate>19760807</enddate><creator>Horne, C.H.W</creator><creator>Reid, I.N</creator><creator>Milne, G.D</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>ASE</scope><scope>C1K</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>KB~</scope><scope>M7N</scope><scope>NAPCQ</scope></search><sort><creationdate>19760807</creationdate><title>PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS</title><author>Horne, C.H.W ; Reid, I.N ; Milne, G.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-8510a6c11186ba9f8a5ae0a8f86637f807052eb7703299a39e7579eafd4fab3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Breast cancer</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Cytoplasm</topic><topic>Enzymes</topic><topic>Glycoproteins</topic><topic>Medical prognosis</topic><topic>Pituitary (anterior)</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horne, C.H.W</creatorcontrib><creatorcontrib>Reid, I.N</creatorcontrib><creatorcontrib>Milne, G.D</creatorcontrib><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Newsstand Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horne, C.H.W</au><au>Reid, I.N</au><au>Milne, G.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS</atitle><jtitle>The Lancet (British edition)</jtitle><date>1976-08-07</date><risdate>1976</risdate><volume>308</volume><issue>7980</issue><spage>279</spage><epage>282</epage><pages>279-282</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><abstract>50 cases of cancer of the breast (diagnosed between 1962 and 1966) were studied retrospectively. An enzyme-bridge immunoperoxidase technique was used to demonstrate that so-called pregnancy-specific proteins were detectable in the cytoplasm of the tumour cells. Of the proteins studied, pregnancy-specific β1-glycoprotein was present in 76% of cases, placental lactogen in 82%, and chorionic gonadotrophin in 60%. Those women with cancers negative for pregnancy-specific β1-glycoprotein and placental lactogen had significantly longer survival-time compared with those whose cancers stained for these proteins. Pregnancy-specific β1—glycoprotein appears to be the best indicator of prognosis. A prospective study is needed to determine wether those patients requiring adjuvant chemotherapy after mastectomy can be identified by staining tumour tissue for pregnancy-specific β1-glyco- protein by the enzyme-bridge technique.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(76)90731-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1976-08, Vol.308 (7980), p.279-282 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_proquest_journals_2054773312 |
| source | Elsevier ScienceDirect Journals |
| subjects | Breast cancer Cancer Chemotherapy Cytoplasm Enzymes Glycoproteins Medical prognosis Pituitary (anterior) Placenta Pregnancy Proteins Tumors |
| title | PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T04%3A51%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PROGNOSTIC%20SIGNIFICANCE%20OF%20INAPPROPRIATE%20PRODUCTION%20OF%20PREGNANCY%20PROTEINS%20BY%20BREAST%20CANCERS&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Horne,%20C.H.W&rft.date=1976-08-07&rft.volume=308&rft.issue=7980&rft.spage=279&rft.epage=282&rft.pages=279-282&rft.issn=0140-6736&rft.eissn=1474-547X&rft_id=info:doi/10.1016/S0140-6736(76)90731-5&rft_dat=%3Cproquest_cross%3E2054773312%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2054773312&rft_id=info:pmid/&rft_els_id=S0140673676907315&rfr_iscdi=true |