HPLC‐ECD and TDDFT‐ECD study of hexahydropyrrolo[1,2‐a]quinoline derivatives

Synthesis of racemic hexahydropyrrolo[1,2‐a]quinoline derivatives (1‐8) was performed by utilizing the Knoevenagel‐[1,5]‐hydride shift‐cyclization domino reaction. Separation of the enantiomers of the chiral products (1‐8) was carried out by chiral high‐performance liquid chromatography, and online...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 2018-07, Vol.30 (7), p.866-874
Hauptverfasser:	Tóth, László, Mándi, Attila, Váradi, Dániel, Kovács, Tibor, Szabados, Anna, Kiss‐Szikszai, Attila, Gong, Qi, Zhang, Haiyan, Mátyus, Péter, Antus, Sándor, Kurtán, Tibor
Format:	Artikel
Sprache:	eng
Schlagworte:	[1,5]‐hydride shift Absolute configuration Acetylcholinesterase Cascade chemical reactions Chromatography Circular dichroism Configurations C‐H activation Density functional theory Deprivation Derivatives Dichroism Enantiomers High performance liquid chromatography Liquid chromatography Metals Neuroprotection Neurotoxicity Quinoline relative and absolute configuration Stereoisomers Time dependence
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