Oxidative radical cascade cyclization involving C(sp 3 )–C(sp 3 ), C(sp 3 )–C(sp 2 ) and C(sp 2 )–N bonds formation: direct construction of cyano and methyl substituted polyheterocycles

Oxidative radical cascade cyclization involving C(sp 3 )–C(sp 3 ), C(sp 3 )–C(sp 2 ) and C(sp 2 )–N bonds formation: direct construction of cyano and methyl substituted polyheterocycles

An oxidative radical cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with acetonitrile has been developed. The reaction provides a straightforward and practical access to cyano substituted pyrido[4,3,2- gh ]phenanthridines, and exhibits a good functional group tolerance. Furthermore...

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Veröffentlicht in:Organic Chemistry Frontiers 2018-06, Vol.5 (12), p.1945-1949
Hauptverfasser: Shang, Jia-Qi, Wang, Shi-Sheng, Fu, Hong, Li, Yi, Yang, Tao, Li, Ya-Min
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Acetonitrile
Functional groups
Organic chemistry
Substitutes
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container_end_page 1949
container_issue 12
container_start_page 1945
container_title Organic Chemistry Frontiers
container_volume 5
creator Shang, Jia-Qi
Wang, Shi-Sheng
Fu, Hong
Li, Yi
Yang, Tao
Li, Ya-Min
description An oxidative radical cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with acetonitrile has been developed. The reaction provides a straightforward and practical access to cyano substituted pyrido[4,3,2- gh ]phenanthridines, and exhibits a good functional group tolerance. Furthermore, such methyl substituted polyheterocycles were also obtained through a similar radical cascade.
doi_str_mv 10.1039/C8QO00336J
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source Royal Society Of Chemistry Journals 2008-
subjects Acetonitrile
Functional groups
Organic chemistry
Substitutes
title Oxidative radical cascade cyclization involving C(sp 3 )–C(sp 3 ), C(sp 3 )–C(sp 2 ) and C(sp 2 )–N bonds formation: direct construction of cyano and methyl substituted polyheterocycles
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