Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies

The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specif...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (48), p.6161-6164
Hauptverfasser: Shivatare, Sachin S, Huang, Lin-Ya, Zeng, Yi-Fang, Liao, Jung-Yu, You, Tsai-Hong, Wang, Shi-Yun, Cheng, Ting, Chiu, Chih-Wei, Chao, Ping, Chen, Li-Tzu, Tsai, Tsung-I, Huang, Chiu-Chen, Wu, Chung-Yi, Lin, Nan-Horng, Wong, Chi-Huey
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Glycan
Mannose
Substrates
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Zusammenfassung:The first systematic investigation of the effect of high mannose, hybrid, and bi- and tri-antennary complex type glycans on the effector functions of antibodies was achieved by the discovery of novel Endo-S2 mutants generated by site-directed mutagenesis as glycosynthases with broad substrate specificity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03384f