Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals
Three new complexes of palladium( ii ) floroquinolone drugs (levofloxacin (HLVX), pefloxacin mesylate (HPFX) and lomefloxacin (HLMX)) were prepared in alkaline media at pH = 9. The suggested chemical formula was assigned as [Pd(L) 2 ] (where L = LVX, PFX and LMX). These complexes were explored by el...
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| creator | El-Megharbel, Samy M. Hegab, Mohamed S. Manaaa, El-Sayed A. Al-Humaidi, Jehan Y. Refat, Moamen S. |
| description | Three new complexes of palladium(
ii
) floroquinolone drugs (levofloxacin (HLVX), pefloxacin mesylate (HPFX) and lomefloxacin (HLMX)) were prepared in alkaline media at pH = 9. The suggested chemical formula was assigned as [Pd(L)
2
] (where L = LVX, PFX and LMX). These complexes were explored by elementary analyses, conductivity tests, infrared and proton NMR spectroscopy, and thermogravimetric analysis and its deferential tools. The homogeneity, surface morphology and particle size of the as-synthesized solid palladium(
ii
) complex were investigated using X-ray powder diffraction and transmittance electron microscopy. FT-IR and
1
H-NMR spectroscopy techniques. The results reveal that HLVX, HPFX and HLMX fluoroquinolones act as bidentate chelates coordinated to the palladium(
ii
) central metal ion
via
the oxygen of carboxylate and carbonyl groups. The palladium(
ii
) metal ion produces a stable six-membered ring with distorted octahedral structure. The conductivity measurement results deduced that these chelates are non-electrolytic in 1 : 2 stoichiometric ratio. Thermal analysis (TG/DTG) was applied to ascertain the stability of the as-synthesized complexes in comparison to free floroquinolone drugs. The thermal decomposition pathways show that the final residual product is pure PdO. Thermodynamic parameters such as energy of activation
E
*, entropy Δ
S
*, enthalpy Δ
H
* and Gibbs free energy Δ
G
* of activation were calculated using Coats–Redfern and Horowitz–Metzger non-isothermal techniques. The particle sizes of palladium(
ii
) complexes were measured within nanoscale range, dependent on morphological tools (XRD and TEM). Molecular docking assessment of the three floroquinolones against prostate cancer mutant 2q7k-hormone receptor is discussed. To our knowledge, this paper presents the first-time synthesis and physicochemical characterizations of a coordination complex of palladium(
ii
) metal ions with floroquinolone and its use as a medicinal model against cancer cells. |
| doi_str_mv | 10.1039/C8NJ01045E |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2053072897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2053072897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c259t-38d858c54de68aef9484484c238c29ea780acde130e25ac44a4445e0678851d3</originalsourceid><addsrcrecordid>eNpFUV1v1TAMrRBIjMELvyASL4BUSNqkTXlDV_sATdsDe6-M466Z0qQkKdPl5_HLlnuHhGTpWPbx8bFcVW8F_yR4O3ze6evvXHCpzp5VJ6LthnpoOvG85ELKmivZvaxepXTPuRB9J06qvz_2Ps-UbGLgDVvnfbIYcKbFIjiGM0TATNH-gWyDTyxMDEOIxvpjgf2k_EDk2QrOgbHb8p5Zyz6whXKZP4482DyzyYUYfm3WBxc8MRO3u7IyFZ6xWMQcW4Ihx-AOrE-ZIXikyJCcS1-YD79L76jpwlpMLYC05YPH9Lp6MRWgN__wtLo9P7vdXdZXNxffdl-vamzUkOtWG600Kmmo00DTILUsgU2rsRkIes0BDYmWU6MApQQppSLe9VorYdrT6t2T7Hq4g1Ie78MWi_E0Nly1vG_00BfWxycWxpBSpGlco10g7kfBx8OLxv8vah8BC_OJGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2053072897</pqid></control><display><type>article</type><title>Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>El-Megharbel, Samy M. ; Hegab, Mohamed S. ; Manaaa, El-Sayed A. ; Al-Humaidi, Jehan Y. ; Refat, Moamen S.</creator><creatorcontrib>El-Megharbel, Samy M. ; Hegab, Mohamed S. ; Manaaa, El-Sayed A. ; Al-Humaidi, Jehan Y. ; Refat, Moamen S.</creatorcontrib><description>Three new complexes of palladium(
ii
) floroquinolone drugs (levofloxacin (HLVX), pefloxacin mesylate (HPFX) and lomefloxacin (HLMX)) were prepared in alkaline media at pH = 9. The suggested chemical formula was assigned as [Pd(L)
2
] (where L = LVX, PFX and LMX). These complexes were explored by elementary analyses, conductivity tests, infrared and proton NMR spectroscopy, and thermogravimetric analysis and its deferential tools. The homogeneity, surface morphology and particle size of the as-synthesized solid palladium(
ii
) complex were investigated using X-ray powder diffraction and transmittance electron microscopy. FT-IR and
1
H-NMR spectroscopy techniques. The results reveal that HLVX, HPFX and HLMX fluoroquinolones act as bidentate chelates coordinated to the palladium(
ii
) central metal ion
via
the oxygen of carboxylate and carbonyl groups. The palladium(
ii
) metal ion produces a stable six-membered ring with distorted octahedral structure. The conductivity measurement results deduced that these chelates are non-electrolytic in 1 : 2 stoichiometric ratio. Thermal analysis (TG/DTG) was applied to ascertain the stability of the as-synthesized complexes in comparison to free floroquinolone drugs. The thermal decomposition pathways show that the final residual product is pure PdO. Thermodynamic parameters such as energy of activation
E
*, entropy Δ
S
*, enthalpy Δ
H
* and Gibbs free energy Δ
G
* of activation were calculated using Coats–Redfern and Horowitz–Metzger non-isothermal techniques. The particle sizes of palladium(
ii
) complexes were measured within nanoscale range, dependent on morphological tools (XRD and TEM). Molecular docking assessment of the three floroquinolones against prostate cancer mutant 2q7k-hormone receptor is discussed. To our knowledge, this paper presents the first-time synthesis and physicochemical characterizations of a coordination complex of palladium(
ii
) metal ions with floroquinolone and its use as a medicinal model against cancer cells.</description><identifier>ISSN: 1144-0546</identifier><identifier>EISSN: 1369-9261</identifier><identifier>DOI: 10.1039/C8NJ01045E</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Activation energy ; Cancer ; Carbonyl groups ; Carbonyls ; Chelates ; Chemical synthesis ; Coordination compounds ; Drugs ; Electrolytic cells ; Enthalpy ; Entropy of activation ; Fourier transforms ; Free energy ; Gibbs free energy ; Infrared analysis ; Infrared spectroscopy ; Metal ions ; Molecular chains ; Molecular docking ; Morphology ; NMR spectroscopy ; Organic chemistry ; Rangefinding ; Spectrum analysis ; Thermal analysis ; Thermal decomposition</subject><ispartof>New journal of chemistry, 2018, Vol.42 (12), p.9709-9719</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c259t-38d858c54de68aef9484484c238c29ea780acde130e25ac44a4445e0678851d3</citedby><cites>FETCH-LOGICAL-c259t-38d858c54de68aef9484484c238c29ea780acde130e25ac44a4445e0678851d3</cites><orcidid>0000-0002-4118-9781</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27902,27903,27904</link.rule.ids></links><search><creatorcontrib>El-Megharbel, Samy M.</creatorcontrib><creatorcontrib>Hegab, Mohamed S.</creatorcontrib><creatorcontrib>Manaaa, El-Sayed A.</creatorcontrib><creatorcontrib>Al-Humaidi, Jehan Y.</creatorcontrib><creatorcontrib>Refat, Moamen S.</creatorcontrib><title>Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals</title><title>New journal of chemistry</title><description>Three new complexes of palladium(
ii
) floroquinolone drugs (levofloxacin (HLVX), pefloxacin mesylate (HPFX) and lomefloxacin (HLMX)) were prepared in alkaline media at pH = 9. The suggested chemical formula was assigned as [Pd(L)
2
] (where L = LVX, PFX and LMX). These complexes were explored by elementary analyses, conductivity tests, infrared and proton NMR spectroscopy, and thermogravimetric analysis and its deferential tools. The homogeneity, surface morphology and particle size of the as-synthesized solid palladium(
ii
) complex were investigated using X-ray powder diffraction and transmittance electron microscopy. FT-IR and
1
H-NMR spectroscopy techniques. The results reveal that HLVX, HPFX and HLMX fluoroquinolones act as bidentate chelates coordinated to the palladium(
ii
) central metal ion
via
the oxygen of carboxylate and carbonyl groups. The palladium(
ii
) metal ion produces a stable six-membered ring with distorted octahedral structure. The conductivity measurement results deduced that these chelates are non-electrolytic in 1 : 2 stoichiometric ratio. Thermal analysis (TG/DTG) was applied to ascertain the stability of the as-synthesized complexes in comparison to free floroquinolone drugs. The thermal decomposition pathways show that the final residual product is pure PdO. Thermodynamic parameters such as energy of activation
E
*, entropy Δ
S
*, enthalpy Δ
H
* and Gibbs free energy Δ
G
* of activation were calculated using Coats–Redfern and Horowitz–Metzger non-isothermal techniques. The particle sizes of palladium(
ii
) complexes were measured within nanoscale range, dependent on morphological tools (XRD and TEM). Molecular docking assessment of the three floroquinolones against prostate cancer mutant 2q7k-hormone receptor is discussed. To our knowledge, this paper presents the first-time synthesis and physicochemical characterizations of a coordination complex of palladium(
ii
) metal ions with floroquinolone and its use as a medicinal model against cancer cells.</description><subject>Activation energy</subject><subject>Cancer</subject><subject>Carbonyl groups</subject><subject>Carbonyls</subject><subject>Chelates</subject><subject>Chemical synthesis</subject><subject>Coordination compounds</subject><subject>Drugs</subject><subject>Electrolytic cells</subject><subject>Enthalpy</subject><subject>Entropy of activation</subject><subject>Fourier transforms</subject><subject>Free energy</subject><subject>Gibbs free energy</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Metal ions</subject><subject>Molecular chains</subject><subject>Molecular docking</subject><subject>Morphology</subject><subject>NMR spectroscopy</subject><subject>Organic chemistry</subject><subject>Rangefinding</subject><subject>Spectrum analysis</subject><subject>Thermal analysis</subject><subject>Thermal decomposition</subject><issn>1144-0546</issn><issn>1369-9261</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpFUV1v1TAMrRBIjMELvyASL4BUSNqkTXlDV_sATdsDe6-M466Z0qQkKdPl5_HLlnuHhGTpWPbx8bFcVW8F_yR4O3ze6evvXHCpzp5VJ6LthnpoOvG85ELKmivZvaxepXTPuRB9J06qvz_2Ps-UbGLgDVvnfbIYcKbFIjiGM0TATNH-gWyDTyxMDEOIxvpjgf2k_EDk2QrOgbHb8p5Zyz6whXKZP4482DyzyYUYfm3WBxc8MRO3u7IyFZ6xWMQcW4Ihx-AOrE-ZIXikyJCcS1-YD79L76jpwlpMLYC05YPH9Lp6MRWgN__wtLo9P7vdXdZXNxffdl-vamzUkOtWG600Kmmo00DTILUsgU2rsRkIes0BDYmWU6MApQQppSLe9VorYdrT6t2T7Hq4g1Ie78MWi_E0Nly1vG_00BfWxycWxpBSpGlco10g7kfBx8OLxv8vah8BC_OJGQ</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>El-Megharbel, Samy M.</creator><creator>Hegab, Mohamed S.</creator><creator>Manaaa, El-Sayed A.</creator><creator>Al-Humaidi, Jehan Y.</creator><creator>Refat, Moamen S.</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>H9R</scope><scope>JG9</scope><scope>KA0</scope><orcidid>https://orcid.org/0000-0002-4118-9781</orcidid></search><sort><creationdate>2018</creationdate><title>Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals</title><author>El-Megharbel, Samy M. ; Hegab, Mohamed S. ; Manaaa, El-Sayed A. ; Al-Humaidi, Jehan Y. ; Refat, Moamen S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c259t-38d858c54de68aef9484484c238c29ea780acde130e25ac44a4445e0678851d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Activation energy</topic><topic>Cancer</topic><topic>Carbonyl groups</topic><topic>Carbonyls</topic><topic>Chelates</topic><topic>Chemical synthesis</topic><topic>Coordination compounds</topic><topic>Drugs</topic><topic>Electrolytic cells</topic><topic>Enthalpy</topic><topic>Entropy of activation</topic><topic>Fourier transforms</topic><topic>Free energy</topic><topic>Gibbs free energy</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Metal ions</topic><topic>Molecular chains</topic><topic>Molecular docking</topic><topic>Morphology</topic><topic>NMR spectroscopy</topic><topic>Organic chemistry</topic><topic>Rangefinding</topic><topic>Spectrum analysis</topic><topic>Thermal analysis</topic><topic>Thermal decomposition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Megharbel, Samy M.</creatorcontrib><creatorcontrib>Hegab, Mohamed S.</creatorcontrib><creatorcontrib>Manaaa, El-Sayed A.</creatorcontrib><creatorcontrib>Al-Humaidi, Jehan Y.</creatorcontrib><creatorcontrib>Refat, Moamen S.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Illustrata: Natural Sciences</collection><collection>Materials Research Database</collection><collection>ProQuest Illustrata: Technology Collection</collection><jtitle>New journal of chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Megharbel, Samy M.</au><au>Hegab, Mohamed S.</au><au>Manaaa, El-Sayed A.</au><au>Al-Humaidi, Jehan Y.</au><au>Refat, Moamen S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals</atitle><jtitle>New journal of chemistry</jtitle><date>2018</date><risdate>2018</risdate><volume>42</volume><issue>12</issue><spage>9709</spage><epage>9719</epage><pages>9709-9719</pages><issn>1144-0546</issn><eissn>1369-9261</eissn><abstract>Three new complexes of palladium(
ii
) floroquinolone drugs (levofloxacin (HLVX), pefloxacin mesylate (HPFX) and lomefloxacin (HLMX)) were prepared in alkaline media at pH = 9. The suggested chemical formula was assigned as [Pd(L)
2
] (where L = LVX, PFX and LMX). These complexes were explored by elementary analyses, conductivity tests, infrared and proton NMR spectroscopy, and thermogravimetric analysis and its deferential tools. The homogeneity, surface morphology and particle size of the as-synthesized solid palladium(
ii
) complex were investigated using X-ray powder diffraction and transmittance electron microscopy. FT-IR and
1
H-NMR spectroscopy techniques. The results reveal that HLVX, HPFX and HLMX fluoroquinolones act as bidentate chelates coordinated to the palladium(
ii
) central metal ion
via
the oxygen of carboxylate and carbonyl groups. The palladium(
ii
) metal ion produces a stable six-membered ring with distorted octahedral structure. The conductivity measurement results deduced that these chelates are non-electrolytic in 1 : 2 stoichiometric ratio. Thermal analysis (TG/DTG) was applied to ascertain the stability of the as-synthesized complexes in comparison to free floroquinolone drugs. The thermal decomposition pathways show that the final residual product is pure PdO. Thermodynamic parameters such as energy of activation
E
*, entropy Δ
S
*, enthalpy Δ
H
* and Gibbs free energy Δ
G
* of activation were calculated using Coats–Redfern and Horowitz–Metzger non-isothermal techniques. The particle sizes of palladium(
ii
) complexes were measured within nanoscale range, dependent on morphological tools (XRD and TEM). Molecular docking assessment of the three floroquinolones against prostate cancer mutant 2q7k-hormone receptor is discussed. To our knowledge, this paper presents the first-time synthesis and physicochemical characterizations of a coordination complex of palladium(
ii
) metal ions with floroquinolone and its use as a medicinal model against cancer cells.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/C8NJ01045E</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4118-9781</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1144-0546 |
| ispartof | New journal of chemistry, 2018, Vol.42 (12), p.9709-9719 |
| issn | 1144-0546 1369-9261 |
| language | eng |
| recordid | cdi_proquest_journals_2053072897 |
| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Activation energy Cancer Carbonyl groups Carbonyls Chelates Chemical synthesis Coordination compounds Drugs Electrolytic cells Enthalpy Entropy of activation Fourier transforms Free energy Gibbs free energy Infrared analysis Infrared spectroscopy Metal ions Molecular chains Molecular docking Morphology NMR spectroscopy Organic chemistry Rangefinding Spectrum analysis Thermal analysis Thermal decomposition |
| title | Synthesis and physicochemical characterizations of coordination between palladium( ii ) metal ions with floroquinolone drugs as medicinal model against cancer cells: novel metallopharmaceuticals |
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