Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

ABSTRACTAngiotensin II (Ang II) is now believed to play a critical role in the pathogenesis of hypertrophy and/or hyperplasia of vascular smooth muscle cells (VSMCs). Several Gi- and Gq-coupled receptors, including the Ang II type 1 (AT1) receptor, activate Rho and Rho-associated kinase in Swiss 3T3...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-01, Vol.35 (1, Part 2 Suppl), p.313-313
Hauptverfasser:	Yamakawa, Tadashi, Tanaka, Shun-ichi, Numaguchi, Kotaro, Yamakawa, Yuko, Motley, Evangeline D, Ichihara, Sahoko, Inagami, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases - pharmacology Amides - pharmacology Angiotensin II - pharmacology Animals Aorta, Thoracic - cytology Biological Transport - drug effects Botulinum Toxins Carrier Proteins Cells, Cultured Enzyme Inhibitors - pharmacology Gene Expression - drug effects Hypertrophy Intracellular Signaling Peptides and Proteins Leucine - pharmacokinetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - pathology Phosphoproteins - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-fos - genetics Pyridines - pharmacology Rats Rats, Sprague-Dawley rho GTP-Binding Proteins - metabolism rho-Associated Kinases Ribosomal Protein S6 Kinases - metabolism RNA, Messenger - analysis
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