Different Contributions of Endothelin-A and Endothelin-B Receptors in the Pathogenesis of Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats

We investigated the involvement of actions mediated by endothelin-A (ETA) and endothelin-B (ETB) receptors in the pathogenesis of deoxycorticosterone acetate (DOCA)-salt-induced hypertension in rats. Two weeks after the start of DOCA-salt treatment, rats were given ABT-627 (10 [mg/kg]/d), a selectiv...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-02, Vol.33 (2), p.759-765
Hauptverfasser:	Matsumura, Yasuo, Hashimoto, Norio, Taira, Shima, Kuro, Toshihiko, Kitano, Rika, Ohkita, Mamoru, Opgenorth, Terry J, Takaoka, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Aorta - physiopathology Arterial hypertension. Arterial hypotension Atrasentan Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Desoxycorticosterone Endothelin Receptor Antagonists Endothelin-1 - metabolism Endothelin-2 - metabolism Experimental diseases Hypertension - chemically induced Hypertension - metabolism Hypertension - pathology Hypertension - physiopathology Male Medical sciences Nephrectomy Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Receptors, Endothelin - metabolism
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