Instability of the Null Steady State: The Fundamental Problem of Inhibiting Malignant Cell Growth

Mathematical modeling of the process of inhibiting malignant growth by common chemotherapeutic agents and biological therapeutics is used to investigate the effect kinetic parameters of the model have on the outcome of treatment. It is shown that the ultimate suppression of growth, i.e., the formati...

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Veröffentlicht in:	Russian Journal of Physical Chemistry A 2018-07, Vol.92 (7), p.1423-1428
Hauptverfasser:	Varfolomeev, S. D., Lukovenkov, A. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biophysical Chemistry Chemistry Chemistry and Materials Science Chemotherapy Physical Chemistry Stability Steady state
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description	Mathematical modeling of the process of inhibiting malignant growth by common chemotherapeutic agents and biological therapeutics is used to investigate the effect kinetic parameters of the model have on the outcome of treatment. It is shown that the ultimate suppression of growth, i.e., the formation of a stable steady-state with no cancer cells, cannot be attained if only the means of classical chemotherapy are used.
doi_str_mv	10.1134/S0036024418070300
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subjects	Biophysical Chemistry Chemistry Chemistry and Materials Science Chemotherapy Physical Chemistry Stability Steady state
title	Instability of the Null Steady State: The Fundamental Problem of Inhibiting Malignant Cell Growth
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