Highly Efficiently Synthesis of Disubstituted Pyrrole Derivatives via Rh(III)-Catalyzed Direct C–H Alkylation Under Mild Conditions

A mild and highly efficient Rh(III)-catalyzed direct C–H alkylation of pyrroles with diazo compounds has been developed. This green and atom-economic catalytic process enables an efficient access to various densely functionalized pyrrole derivatives in good to excellent yields, and it is potentially applicable to the large-scale synthesis of pyrrole derivatives.