Urinary Potassium Excretion and Sodium Sensitivity in Blacks

ABSTRACT—Based on racial differences in urinary potassium excretion and responses to diuretics, we present a model suggesting that a major cause of sodium sensitivity in blacks is an augmented activity of the Na-K-2Cl cotransport in the thick ascending limb of Henle’s loop. This would result in an i...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-04, Vol.43 (4), p.707-713
Hauptverfasser:	Aviv, Abraham, Hollenberg, Norman K, Weder, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	African Continental Ancestry Group - genetics Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chlorides - pharmacokinetics Clinical manifestations. Epidemiology. Investigative techniques. Etiology Disease Models, Animal Diuresis - genetics Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Hypertension - ethnology Hypertension - etiology Hypertension - genetics Hypertension - physiopathology Ion Transport - genetics Kidney Glomerulus - pathology Kidney Glomerulus - physiopathology Kidney Tubules - metabolism Loop of Henle - metabolism Medical sciences Models, Biological Natriuresis - genetics Potassium - pharmacokinetics Potassium - urine Rats Rats, Inbred Dahl Selection, Genetic Sodium Chloride, Dietary - adverse effects Sodium Chloride, Dietary - pharmacokinetics Sodium, Dietary - adverse effects Sodium, Dietary - pharmacokinetics Sodium-Potassium-Chloride Symporters - genetics Sodium-Potassium-Chloride Symporters - metabolism Vertebrates: urinary system
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