Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely prescribed to lower cholesterol. Recent reports suggest that statins may promote angiogenesis in ischemic tissues. It remains to be elucidated whether statins potentially enhance unfavorable angiogenesis associated wi...
Gespeichert in:
| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-06, Vol.43 (6), p.1214-1220 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1220 |
|---|---|
| container_issue | 6 |
| container_start_page | 1214 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 43 |
| creator | Sata, Masataka Nishimatsu, Hiroaki Osuga, Jun-ichi Tanaka, Kimie Ishizaka, Nobukazu Ishibashi, Shun Hirata, Yasunobu Nagai, Ryozo |
| description | 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely prescribed to lower cholesterol. Recent reports suggest that statins may promote angiogenesis in ischemic tissues. It remains to be elucidated whether statins potentially enhance unfavorable angiogenesis associated with tumor and atherosclerosis. Here, we induced hind limb ischemia in wild-type mice by resecting the right femoral artery and subsequently inoculated cancer cells in the same animal. Cerivastatin enhanced blood flow recovery in the ischemic hind limb as determined by laser Doppler imaging, whereas tumor growth was significantly retarded. Cerivastatin did not affect capillary density in tumors. Cerivastatin, pitavastatin, and fluvastatin inhibited atherosclerotic lesion progression in apolipoprotein E-deficient mice, whereas they augmented blood flow recovery and capillary formation in ischemic hind limb. Low-dose statins were more effective than high-dose statins in both augmentation of collateral flow recovery and inhibition of atherosclerosis. These results suggest that statins may not promote the development of cancer and atherosclerosis at the doses that augment collateral flow growth in ischemic tissues. |
| doi_str_mv | 10.1161/01.HYP.0000126186.29571.41 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_205277585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>644472151</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4816-566198aac4a087bb542bb94351835b8dda394b836204c5ac0b42ee4d1fd1b6873</originalsourceid><addsrcrecordid>eNpFkEFv1DAQhS0EokvhLyCr9wSPM3YcbqsF2koVVFAkOFl24iUpSbzYjlb77_F2V-ocZjTS9-aNHiFXwEoACR8YlDe_70uWC7gEJUveiBpKhBdkBYJjgUJWL8mKQYNFA_DrgryJ8THjiFi_JhcgQGYhW5HxRzJpmCNdL38mNye68eNokgtmpNfB71NPh5l-d3Hn5-ho8vQ2tr2bBkPtkuhD7w70k6dffaL3wU8-Oboxc-sCNXNH16l3wcd2PPYhviWvtmaM7t15XpKfXz4_bG6Ku2_Xt5v1XdGiAlmI_FujjGnRMFVbK5Bb22AlQFXCqq4zVYNWVZIzbIVpmUXuHHaw7cBKVVeX5Op0dxf8v8XFpB_9EuZsqTkTvK6FEhn6eILa_FsMbqt3YZhMOGhg-pizZqD7w04_56yfctYIWfz-7LDYyXXP0nOwGcATsPdjTjP-HZe9C7p3Zkz900nkUhU8TybzVhxNZPUfb0qJOQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>205277585</pqid></control><display><type>article</type><title>Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Complete</source><creator>Sata, Masataka ; Nishimatsu, Hiroaki ; Osuga, Jun-ichi ; Tanaka, Kimie ; Ishizaka, Nobukazu ; Ishibashi, Shun ; Hirata, Yasunobu ; Nagai, Ryozo</creator><creatorcontrib>Sata, Masataka ; Nishimatsu, Hiroaki ; Osuga, Jun-ichi ; Tanaka, Kimie ; Ishizaka, Nobukazu ; Ishibashi, Shun ; Hirata, Yasunobu ; Nagai, Ryozo</creatorcontrib><description>3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely prescribed to lower cholesterol. Recent reports suggest that statins may promote angiogenesis in ischemic tissues. It remains to be elucidated whether statins potentially enhance unfavorable angiogenesis associated with tumor and atherosclerosis. Here, we induced hind limb ischemia in wild-type mice by resecting the right femoral artery and subsequently inoculated cancer cells in the same animal. Cerivastatin enhanced blood flow recovery in the ischemic hind limb as determined by laser Doppler imaging, whereas tumor growth was significantly retarded. Cerivastatin did not affect capillary density in tumors. Cerivastatin, pitavastatin, and fluvastatin inhibited atherosclerotic lesion progression in apolipoprotein E-deficient mice, whereas they augmented blood flow recovery and capillary formation in ischemic hind limb. Low-dose statins were more effective than high-dose statins in both augmentation of collateral flow recovery and inhibition of atherosclerosis. These results suggest that statins may not promote the development of cancer and atherosclerosis at the doses that augment collateral flow growth in ischemic tissues.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.HYP.0000126186.29571.41</identifier><identifier>PMID: 15166180</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Apolipoproteins E - deficiency ; Apolipoproteins E - genetics ; Arteriosclerosis - chemically induced ; Arteriosclerosis - etiology ; Arteriosclerosis - genetics ; Fatty Acids, Monounsaturated - administration & dosage ; Fatty Acids, Monounsaturated - pharmacology ; Fatty Acids, Monounsaturated - therapeutic use ; Femoral Artery - surgery ; Hindlimb - blood supply ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity ; Hypercholesterolemia - complications ; Hypercholesterolemia - genetics ; Indoles - administration & dosage ; Indoles - pharmacology ; Indoles - therapeutic use ; Ischemia - drug therapy ; Ischemia - physiopathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neovascularization, Pathologic - chemically induced ; Neovascularization, Physiologic - drug effects ; Nitric Oxide Synthase - metabolism ; Nitric Oxide Synthase Type II ; Nitric Oxide Synthase Type III ; Pyridines - administration & dosage ; Pyridines - pharmacology ; Pyridines - therapeutic use ; Pyridines - toxicity ; Quinolines - administration & dosage ; Quinolines - pharmacology ; Quinolines - therapeutic use</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2004-06, Vol.43 (6), p.1214-1220</ispartof><rights>2004 American Heart Association, Inc.</rights><rights>Copyright American Heart Association, Inc. Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4816-566198aac4a087bb542bb94351835b8dda394b836204c5ac0b42ee4d1fd1b6873</citedby><cites>FETCH-LOGICAL-c4816-566198aac4a087bb542bb94351835b8dda394b836204c5ac0b42ee4d1fd1b6873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3689,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15166180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sata, Masataka</creatorcontrib><creatorcontrib>Nishimatsu, Hiroaki</creatorcontrib><creatorcontrib>Osuga, Jun-ichi</creatorcontrib><creatorcontrib>Tanaka, Kimie</creatorcontrib><creatorcontrib>Ishizaka, Nobukazu</creatorcontrib><creatorcontrib>Ishibashi, Shun</creatorcontrib><creatorcontrib>Hirata, Yasunobu</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><title>Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely prescribed to lower cholesterol. Recent reports suggest that statins may promote angiogenesis in ischemic tissues. It remains to be elucidated whether statins potentially enhance unfavorable angiogenesis associated with tumor and atherosclerosis. Here, we induced hind limb ischemia in wild-type mice by resecting the right femoral artery and subsequently inoculated cancer cells in the same animal. Cerivastatin enhanced blood flow recovery in the ischemic hind limb as determined by laser Doppler imaging, whereas tumor growth was significantly retarded. Cerivastatin did not affect capillary density in tumors. Cerivastatin, pitavastatin, and fluvastatin inhibited atherosclerotic lesion progression in apolipoprotein E-deficient mice, whereas they augmented blood flow recovery and capillary formation in ischemic hind limb. Low-dose statins were more effective than high-dose statins in both augmentation of collateral flow recovery and inhibition of atherosclerosis. These results suggest that statins may not promote the development of cancer and atherosclerosis at the doses that augment collateral flow growth in ischemic tissues.</description><subject>Animals</subject><subject>Apolipoproteins E - deficiency</subject><subject>Apolipoproteins E - genetics</subject><subject>Arteriosclerosis - chemically induced</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - genetics</subject><subject>Fatty Acids, Monounsaturated - administration & dosage</subject><subject>Fatty Acids, Monounsaturated - pharmacology</subject><subject>Fatty Acids, Monounsaturated - therapeutic use</subject><subject>Femoral Artery - surgery</subject><subject>Hindlimb - blood supply</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity</subject><subject>Hypercholesterolemia - complications</subject><subject>Hypercholesterolemia - genetics</subject><subject>Indoles - administration & dosage</subject><subject>Indoles - pharmacology</subject><subject>Indoles - therapeutic use</subject><subject>Ischemia - drug therapy</subject><subject>Ischemia - physiopathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Neovascularization, Pathologic - chemically induced</subject><subject>Neovascularization, Physiologic - drug effects</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase Type II</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Pyridines - administration & dosage</subject><subject>Pyridines - pharmacology</subject><subject>Pyridines - therapeutic use</subject><subject>Pyridines - toxicity</subject><subject>Quinolines - administration & dosage</subject><subject>Quinolines - pharmacology</subject><subject>Quinolines - therapeutic use</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFv1DAQhS0EokvhLyCr9wSPM3YcbqsF2koVVFAkOFl24iUpSbzYjlb77_F2V-ocZjTS9-aNHiFXwEoACR8YlDe_70uWC7gEJUveiBpKhBdkBYJjgUJWL8mKQYNFA_DrgryJ8THjiFi_JhcgQGYhW5HxRzJpmCNdL38mNye68eNokgtmpNfB71NPh5l-d3Hn5-ho8vQ2tr2bBkPtkuhD7w70k6dffaL3wU8-Oboxc-sCNXNH16l3wcd2PPYhviWvtmaM7t15XpKfXz4_bG6Ku2_Xt5v1XdGiAlmI_FujjGnRMFVbK5Bb22AlQFXCqq4zVYNWVZIzbIVpmUXuHHaw7cBKVVeX5Op0dxf8v8XFpB_9EuZsqTkTvK6FEhn6eILa_FsMbqt3YZhMOGhg-pizZqD7w04_56yfctYIWfz-7LDYyXXP0nOwGcATsPdjTjP-HZe9C7p3Zkz900nkUhU8TybzVhxNZPUfb0qJOQ</recordid><startdate>200406</startdate><enddate>200406</enddate><creator>Sata, Masataka</creator><creator>Nishimatsu, Hiroaki</creator><creator>Osuga, Jun-ichi</creator><creator>Tanaka, Kimie</creator><creator>Ishizaka, Nobukazu</creator><creator>Ishibashi, Shun</creator><creator>Hirata, Yasunobu</creator><creator>Nagai, Ryozo</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>200406</creationdate><title>Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis</title><author>Sata, Masataka ; Nishimatsu, Hiroaki ; Osuga, Jun-ichi ; Tanaka, Kimie ; Ishizaka, Nobukazu ; Ishibashi, Shun ; Hirata, Yasunobu ; Nagai, Ryozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4816-566198aac4a087bb542bb94351835b8dda394b836204c5ac0b42ee4d1fd1b6873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Apolipoproteins E - deficiency</topic><topic>Apolipoproteins E - genetics</topic><topic>Arteriosclerosis - chemically induced</topic><topic>Arteriosclerosis - etiology</topic><topic>Arteriosclerosis - genetics</topic><topic>Fatty Acids, Monounsaturated - administration & dosage</topic><topic>Fatty Acids, Monounsaturated - pharmacology</topic><topic>Fatty Acids, Monounsaturated - therapeutic use</topic><topic>Femoral Artery - surgery</topic><topic>Hindlimb - blood supply</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity</topic><topic>Hypercholesterolemia - complications</topic><topic>Hypercholesterolemia - genetics</topic><topic>Indoles - administration & dosage</topic><topic>Indoles - pharmacology</topic><topic>Indoles - therapeutic use</topic><topic>Ischemia - drug therapy</topic><topic>Ischemia - physiopathology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Neovascularization, Pathologic - chemically induced</topic><topic>Neovascularization, Physiologic - drug effects</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase Type II</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Pyridines - administration & dosage</topic><topic>Pyridines - pharmacology</topic><topic>Pyridines - therapeutic use</topic><topic>Pyridines - toxicity</topic><topic>Quinolines - administration & dosage</topic><topic>Quinolines - pharmacology</topic><topic>Quinolines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sata, Masataka</creatorcontrib><creatorcontrib>Nishimatsu, Hiroaki</creatorcontrib><creatorcontrib>Osuga, Jun-ichi</creatorcontrib><creatorcontrib>Tanaka, Kimie</creatorcontrib><creatorcontrib>Ishizaka, Nobukazu</creatorcontrib><creatorcontrib>Ishibashi, Shun</creatorcontrib><creatorcontrib>Hirata, Yasunobu</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sata, Masataka</au><au>Nishimatsu, Hiroaki</au><au>Osuga, Jun-ichi</au><au>Tanaka, Kimie</au><au>Ishizaka, Nobukazu</au><au>Ishibashi, Shun</au><au>Hirata, Yasunobu</au><au>Nagai, Ryozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2004-06</date><risdate>2004</risdate><volume>43</volume><issue>6</issue><spage>1214</spage><epage>1220</epage><pages>1214-1220</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, or statins, are widely prescribed to lower cholesterol. Recent reports suggest that statins may promote angiogenesis in ischemic tissues. It remains to be elucidated whether statins potentially enhance unfavorable angiogenesis associated with tumor and atherosclerosis. Here, we induced hind limb ischemia in wild-type mice by resecting the right femoral artery and subsequently inoculated cancer cells in the same animal. Cerivastatin enhanced blood flow recovery in the ischemic hind limb as determined by laser Doppler imaging, whereas tumor growth was significantly retarded. Cerivastatin did not affect capillary density in tumors. Cerivastatin, pitavastatin, and fluvastatin inhibited atherosclerotic lesion progression in apolipoprotein E-deficient mice, whereas they augmented blood flow recovery and capillary formation in ischemic hind limb. Low-dose statins were more effective than high-dose statins in both augmentation of collateral flow recovery and inhibition of atherosclerosis. These results suggest that statins may not promote the development of cancer and atherosclerosis at the doses that augment collateral flow growth in ischemic tissues.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>15166180</pmid><doi>10.1161/01.HYP.0000126186.29571.41</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2004-06, Vol.43 (6), p.1214-1220 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_proquest_journals_205277585 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Animals Apolipoproteins E - deficiency Apolipoproteins E - genetics Arteriosclerosis - chemically induced Arteriosclerosis - etiology Arteriosclerosis - genetics Fatty Acids, Monounsaturated - administration & dosage Fatty Acids, Monounsaturated - pharmacology Fatty Acids, Monounsaturated - therapeutic use Femoral Artery - surgery Hindlimb - blood supply Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hydroxymethylglutaryl-CoA Reductase Inhibitors - toxicity Hypercholesterolemia - complications Hypercholesterolemia - genetics Indoles - administration & dosage Indoles - pharmacology Indoles - therapeutic use Ischemia - drug therapy Ischemia - physiopathology Male Mice Mice, Inbred C57BL Mice, Knockout Neovascularization, Pathologic - chemically induced Neovascularization, Physiologic - drug effects Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Pyridines - administration & dosage Pyridines - pharmacology Pyridines - therapeutic use Pyridines - toxicity Quinolines - administration & dosage Quinolines - pharmacology Quinolines - therapeutic use |
| title | Statins Augment Collateral Growth in Response to Ischemia but They Do Not Promote Cancer and Atherosclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T16%3A17%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Statins%20Augment%20Collateral%20Growth%20in%20Response%20to%20Ischemia%20but%20They%20Do%20Not%20Promote%20Cancer%20and%20Atherosclerosis&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Sata,%20Masataka&rft.date=2004-06&rft.volume=43&rft.issue=6&rft.spage=1214&rft.epage=1220&rft.pages=1214-1220&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/01.HYP.0000126186.29571.41&rft_dat=%3Cproquest_cross%3E644472151%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=205277585&rft_id=info:pmid/15166180&rfr_iscdi=true |