Effects of Insulin on Calcium Metabolism and Platelet Aggregation
The influence of insulin on platelets in vitro has not been exhaustively investigated. To clarify whether insulin affects Calcium () metabolism in platelets directly or through alteration of other systems regulating intracellular Calcium homeostasis, we examined the effect of insulin both alone and...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1996-08, Vol.28 (2), p.209-212 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 28 |
| creator | Ishida, Mari Ishida, Takafumi Ono, Norihisa Matsuura, Hideo Watanabe, Mitsuaki Kajiyama, Goro Kambe, Masayuki Oshima, Tetsuya |
| description | The influence of insulin on platelets in vitro has not been exhaustively investigated. To clarify whether insulin affects Calcium () metabolism in platelets directly or through alteration of other systems regulating intracellular Calcium homeostasis, we examined the effect of insulin both alone and in combination with prostaglandin E (1) on platelet aggregation and Calcium metabolism. Incubation of rat platelets with insulin reduced thrombin-induced Calcium influx but did not change thrombin-evoked release of Calcium from internal stores or the size of internal Calcium stores. The interactive effects of insulin with prostaglandin E1, were only additive, and insulin did not augment the effects of prostaglandin E1 on platelet Calcium metabolism. In contrast, insulin did not inhibit thrombin-induced platelet aggregation but did augment inhibition of platelet aggregation by prostaglandin E1. Our results suggest that insulin inhibits platelet function by both prostaglandin E1, -dependent and -independent mechanisms. (Hypertension. 1996;28:209-212.) |
| doi_str_mv | 10.1161/01.hyp.28.2.209 |
| format | Article |
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To clarify whether insulin affects Calcium () metabolism in platelets directly or through alteration of other systems regulating intracellular Calcium homeostasis, we examined the effect of insulin both alone and in combination with prostaglandin E (1) on platelet aggregation and Calcium metabolism. Incubation of rat platelets with insulin reduced thrombin-induced Calcium influx but did not change thrombin-evoked release of Calcium from internal stores or the size of internal Calcium stores. The interactive effects of insulin with prostaglandin E1, were only additive, and insulin did not augment the effects of prostaglandin E1 on platelet Calcium metabolism. In contrast, insulin did not inhibit thrombin-induced platelet aggregation but did augment inhibition of platelet aggregation by prostaglandin E1. Our results suggest that insulin inhibits platelet function by both prostaglandin E1, -dependent and -independent mechanisms. (Hypertension. 1996;28:209-212.)</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.28.2.209</identifier><identifier>PMID: 8707383</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Calcium - metabolism ; Cells, Cultured ; Drug Interactions ; Fundamental and applied biological sciences. Psychology ; Insulin - pharmacology ; Male ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Prostaglandins E - pharmacology ; Rats ; Rats, Wistar ; Thrombin - pharmacology ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1996-08, Vol.28 (2), p.209-212</ispartof><rights>1996 American Heart Association, Inc.</rights><rights>1996 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Aug 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5009-d939d0623ec042504231015134f384219026160ccd24a1bc2dcc88a20ba3f5c73</citedby><cites>FETCH-LOGICAL-c5009-d939d0623ec042504231015134f384219026160ccd24a1bc2dcc88a20ba3f5c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3685,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3185575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8707383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishida, Mari</creatorcontrib><creatorcontrib>Ishida, Takafumi</creatorcontrib><creatorcontrib>Ono, Norihisa</creatorcontrib><creatorcontrib>Matsuura, Hideo</creatorcontrib><creatorcontrib>Watanabe, Mitsuaki</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><creatorcontrib>Kambe, Masayuki</creatorcontrib><creatorcontrib>Oshima, Tetsuya</creatorcontrib><title>Effects of Insulin on Calcium Metabolism and Platelet Aggregation</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>The influence of insulin on platelets in vitro has not been exhaustively investigated. To clarify whether insulin affects Calcium () metabolism in platelets directly or through alteration of other systems regulating intracellular Calcium homeostasis, we examined the effect of insulin both alone and in combination with prostaglandin E (1) on platelet aggregation and Calcium metabolism. Incubation of rat platelets with insulin reduced thrombin-induced Calcium influx but did not change thrombin-evoked release of Calcium from internal stores or the size of internal Calcium stores. The interactive effects of insulin with prostaglandin E1, were only additive, and insulin did not augment the effects of prostaglandin E1 on platelet Calcium metabolism. In contrast, insulin did not inhibit thrombin-induced platelet aggregation but did augment inhibition of platelet aggregation by prostaglandin E1. Our results suggest that insulin inhibits platelet function by both prostaglandin E1, -dependent and -independent mechanisms. (Hypertension. 1996;28:209-212.)</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Calcium - metabolism</subject><subject>Cells, Cultured</subject><subject>Drug Interactions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Insulin - pharmacology</subject><subject>Male</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Prostaglandins E - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thrombin - pharmacology</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNFr3DAMxs3Y6G7tnvc0CKOvSSXZTuzH47iuhY71YYPuyfgc5y6tL7naCaX__VzuqEAI6ftJgo-xbwgVYo1XgNXu9VCRqqgi0B_YAiWJUsiaf2QLQC1KjfjwmX1J6REAhRDNGTtTDTRc8QVbrrvOuykVY1fcDmkO_VCMQ7GywfXzvvjlJ7sZQ5_2hR3a4j7YyQc_FcvtNvqtnfpxuGCfOhuS_3qq5-zv9frP6qa8-_3zdrW8K50E0GWruW6hJu4dCJI5OQJK5KLjShBqoBprcK4lYXHjqHVOKUuwsbyTruHn7Mfx7iGOz7NPk3kc5zjkl4ZAUsNJQ4aujpCLY0rRd-YQ-72NrwbBvBlmAM3Nv3tDylDe03nj--nsvNn79p0_OZT1y5Nuk7Ohi3ZwfXrHOCopG5kxccRexjD5mJ7C_OKj2Xkbpp2BHIJqVaLWNajclW8jzf8DpP6APg</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>Ishida, Mari</creator><creator>Ishida, Takafumi</creator><creator>Ono, Norihisa</creator><creator>Matsuura, Hideo</creator><creator>Watanabe, Mitsuaki</creator><creator>Kajiyama, Goro</creator><creator>Kambe, Masayuki</creator><creator>Oshima, Tetsuya</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>199608</creationdate><title>Effects of Insulin on Calcium Metabolism and Platelet Aggregation</title><author>Ishida, Mari ; Ishida, Takafumi ; Ono, Norihisa ; Matsuura, Hideo ; Watanabe, Mitsuaki ; Kajiyama, Goro ; Kambe, Masayuki ; Oshima, Tetsuya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5009-d939d0623ec042504231015134f384219026160ccd24a1bc2dcc88a20ba3f5c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Calcium - metabolism</topic><topic>Cells, Cultured</topic><topic>Drug Interactions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Insulin - pharmacology</topic><topic>Male</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Prostaglandins E - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Thrombin - pharmacology</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishida, Mari</creatorcontrib><creatorcontrib>Ishida, Takafumi</creatorcontrib><creatorcontrib>Ono, Norihisa</creatorcontrib><creatorcontrib>Matsuura, Hideo</creatorcontrib><creatorcontrib>Watanabe, Mitsuaki</creatorcontrib><creatorcontrib>Kajiyama, Goro</creatorcontrib><creatorcontrib>Kambe, Masayuki</creatorcontrib><creatorcontrib>Oshima, Tetsuya</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishida, Mari</au><au>Ishida, Takafumi</au><au>Ono, Norihisa</au><au>Matsuura, Hideo</au><au>Watanabe, Mitsuaki</au><au>Kajiyama, Goro</au><au>Kambe, Masayuki</au><au>Oshima, Tetsuya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Insulin on Calcium Metabolism and Platelet Aggregation</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1996-08</date><risdate>1996</risdate><volume>28</volume><issue>2</issue><spage>209</spage><epage>212</epage><pages>209-212</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>The influence of insulin on platelets in vitro has not been exhaustively investigated. To clarify whether insulin affects Calcium () metabolism in platelets directly or through alteration of other systems regulating intracellular Calcium homeostasis, we examined the effect of insulin both alone and in combination with prostaglandin E (1) on platelet aggregation and Calcium metabolism. Incubation of rat platelets with insulin reduced thrombin-induced Calcium influx but did not change thrombin-evoked release of Calcium from internal stores or the size of internal Calcium stores. The interactive effects of insulin with prostaglandin E1, were only additive, and insulin did not augment the effects of prostaglandin E1 on platelet Calcium metabolism. In contrast, insulin did not inhibit thrombin-induced platelet aggregation but did augment inhibition of platelet aggregation by prostaglandin E1. Our results suggest that insulin inhibits platelet function by both prostaglandin E1, -dependent and -independent mechanisms. (Hypertension. 1996;28:209-212.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>8707383</pmid><doi>10.1161/01.hyp.28.2.209</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 1996-08, Vol.28 (2), p.209-212 |
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| language | eng |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Calcium - metabolism Cells, Cultured Drug Interactions Fundamental and applied biological sciences. Psychology Insulin - pharmacology Male Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Prostaglandins E - pharmacology Rats Rats, Wistar Thrombin - pharmacology Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
| title | Effects of Insulin on Calcium Metabolism and Platelet Aggregation |
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