Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model
Histologic evidence of the comparative neurotoxicity of lidocaine, mepivacaine, and prilocaine is incomplete. We compared the intrathecal neurotoxicity in rats among these 3 drugs based on morphologic and neurofunctional findings. Rats (n = 169) randomly received 0.12 μL/g of 0%, 2%, 5%, 7.5%, 10%,...
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| Veröffentlicht in: | Regional anesthesia and pain medicine 2004-09, Vol.29 (5), p.446-453 |
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| description | Histologic evidence of the comparative neurotoxicity of lidocaine, mepivacaine, and prilocaine is incomplete. We compared the intrathecal neurotoxicity in rats among these 3 drugs based on morphologic and neurofunctional findings.
Rats (n = 169) randomly received 0.12 μL/g of 0%, 2%, 5%, 7.5%, 10%, or 20% lidocaine, mepivacaine, or prilocaine or 25% glucose dissolved in distilled water via a chronically implanted intrathecal catheter. The effect of the agents on neurofunction was evaluated by movement of the hind limb (behavior test) and by sensory threshold (paw-stimulation test). The L1 spinal cord, the posterior and anterior roots, and the cauda equina were removed en bloc 5 days later and examined by light and electron microscopy.
A significant decrease in sensory threshold or irreversible hind-limb limitation was observed only in rats receiving 20% lidocaine. Morphologic abnormalities characterized by axonal degeneration were observed in rats receiving ≥7.5% lidocaine, 20% mepivacaine, and 20% prilocaine, at the posterior white matter and the proximal portion of the posterior root just at the entrance into the spinal cord. The incidence of lesions was significantly higher in rats receiving lidocaine than mepivacaine and prilocaine.
It is suggested that intrathecal mepivacaine and prilocaine are less neurotoxic than highly concentrated lidocaine in a rat intrathecal model. |
| doi_str_mv | 10.1016/j.rapm.2004.06.013 |
| format | Article |
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Rats (n = 169) randomly received 0.12 μL/g of 0%, 2%, 5%, 7.5%, 10%, or 20% lidocaine, mepivacaine, or prilocaine or 25% glucose dissolved in distilled water via a chronically implanted intrathecal catheter. The effect of the agents on neurofunction was evaluated by movement of the hind limb (behavior test) and by sensory threshold (paw-stimulation test). The L1 spinal cord, the posterior and anterior roots, and the cauda equina were removed en bloc 5 days later and examined by light and electron microscopy.
A significant decrease in sensory threshold or irreversible hind-limb limitation was observed only in rats receiving 20% lidocaine. Morphologic abnormalities characterized by axonal degeneration were observed in rats receiving ≥7.5% lidocaine, 20% mepivacaine, and 20% prilocaine, at the posterior white matter and the proximal portion of the posterior root just at the entrance into the spinal cord. The incidence of lesions was significantly higher in rats receiving lidocaine than mepivacaine and prilocaine.
It is suggested that intrathecal mepivacaine and prilocaine are less neurotoxic than highly concentrated lidocaine in a rat intrathecal model.</description><identifier>ISSN: 1098-7339</identifier><identifier>EISSN: 1532-8651</identifier><identifier>DOI: 10.1016/j.rapm.2004.06.013</identifier><identifier>PMID: 15372390</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Anesthetics, Local - administration & dosage ; Anesthetics, Local - toxicity ; Animals ; Behavior, Animal - drug effects ; Dose-Response Relationship, Drug ; Hydrogen-Ion Concentration ; Injections, Spinal - methods ; Lidocaine - administration & dosage ; Lidocaine - toxicity ; Local anesthetics ; Male ; Mepivacaine - administration & dosage ; Mepivacaine - toxicity ; Models, Animal ; Movement - drug effects ; Neurotoxicity ; Neurotoxicity Syndromes ; Osmolar Concentration ; Pathology ; Prilocaine - administration & dosage ; Prilocaine - toxicity ; Rats ; Rats, Wistar ; Regional anesthesia ; Sensory impairment ; Sensory Thresholds - drug effects ; Spinal Cord - drug effects ; Spinal Cord - ultrastructure ; Time Factors</subject><ispartof>Regional anesthesia and pain medicine, 2004-09, Vol.29 (5), p.446-453</ispartof><rights>2004 American Society of Regional Anesthesia and Pain Medicine</rights><rights>Copyright Churchill Livingstone Inc., Medical Publishers Sep/Oct 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-4721d9d8fc06565e44358ab6edc8cb1d2c7ce258c2748eb1442f05d9164453013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15372390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takenami, Tamie</creatorcontrib><creatorcontrib>Yagishita, Saburo</creatorcontrib><creatorcontrib>Nara, Yoshihiro</creatorcontrib><creatorcontrib>Hoka, Sumio</creatorcontrib><title>Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model</title><title>Regional anesthesia and pain medicine</title><addtitle>Reg Anesth Pain Med</addtitle><description>Histologic evidence of the comparative neurotoxicity of lidocaine, mepivacaine, and prilocaine is incomplete. We compared the intrathecal neurotoxicity in rats among these 3 drugs based on morphologic and neurofunctional findings.
Rats (n = 169) randomly received 0.12 μL/g of 0%, 2%, 5%, 7.5%, 10%, or 20% lidocaine, mepivacaine, or prilocaine or 25% glucose dissolved in distilled water via a chronically implanted intrathecal catheter. The effect of the agents on neurofunction was evaluated by movement of the hind limb (behavior test) and by sensory threshold (paw-stimulation test). The L1 spinal cord, the posterior and anterior roots, and the cauda equina were removed en bloc 5 days later and examined by light and electron microscopy.
A significant decrease in sensory threshold or irreversible hind-limb limitation was observed only in rats receiving 20% lidocaine. Morphologic abnormalities characterized by axonal degeneration were observed in rats receiving ≥7.5% lidocaine, 20% mepivacaine, and 20% prilocaine, at the posterior white matter and the proximal portion of the posterior root just at the entrance into the spinal cord. The incidence of lesions was significantly higher in rats receiving lidocaine than mepivacaine and prilocaine.
It is suggested that intrathecal mepivacaine and prilocaine are less neurotoxic than highly concentrated lidocaine in a rat intrathecal model.</description><subject>Anesthetics, Local - administration & dosage</subject><subject>Anesthetics, Local - toxicity</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hydrogen-Ion Concentration</subject><subject>Injections, Spinal - methods</subject><subject>Lidocaine - administration & dosage</subject><subject>Lidocaine - toxicity</subject><subject>Local anesthetics</subject><subject>Male</subject><subject>Mepivacaine - administration & dosage</subject><subject>Mepivacaine - toxicity</subject><subject>Models, Animal</subject><subject>Movement - drug effects</subject><subject>Neurotoxicity</subject><subject>Neurotoxicity Syndromes</subject><subject>Osmolar Concentration</subject><subject>Pathology</subject><subject>Prilocaine - administration & dosage</subject><subject>Prilocaine - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regional anesthesia</subject><subject>Sensory impairment</subject><subject>Sensory Thresholds - drug effects</subject><subject>Spinal Cord - drug effects</subject><subject>Spinal Cord - ultrastructure</subject><subject>Time Factors</subject><issn>1098-7339</issn><issn>1532-8651</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAURYMozjj6B1xIcN-apEnaghsRPwYG3Og6pMkrk9KPMWkH_fdmmIKuXOUFzjuPexG6piSlhMq7JvV616WMEJ4SmRKanaAlFRlLCinoaZxJWSR5lpULdBFCQwgpci7P0SJCOctKskR23Y9ej1swusUd7NxeG-16wLq3eOddO8xfD7iFEHAPkx_G4csZPG51j1tnZ8T1WOPoisMf5WChvURntW4DXM3vCn08P70_viabt5f148MmMVlejgnPGbWlLWpDpJACOM9EoSsJ1hSmopaZ3AAThWE5L6CinLOaCFtSybnIYvwVuj16d374nCCMqhkm38eTihFBo1PkEWJHyPghBA-1ijE77b8VJerQq2rUoVd16FURqaI4Lt3M5qnqwP6uzEVG4P4IQMy3d-BVMA56A9Z5MKOyg_vP_wODvYmn</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Takenami, Tamie</creator><creator>Yagishita, Saburo</creator><creator>Nara, Yoshihiro</creator><creator>Hoka, Sumio</creator><general>Elsevier Inc</general><general>BMJ Publishing Group LTD</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope></search><sort><creationdate>20040901</creationdate><title>Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model</title><author>Takenami, Tamie ; Yagishita, Saburo ; Nara, Yoshihiro ; Hoka, Sumio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-4721d9d8fc06565e44358ab6edc8cb1d2c7ce258c2748eb1442f05d9164453013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anesthetics, Local - administration & dosage</topic><topic>Anesthetics, Local - toxicity</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hydrogen-Ion Concentration</topic><topic>Injections, Spinal - methods</topic><topic>Lidocaine - administration & dosage</topic><topic>Lidocaine - toxicity</topic><topic>Local anesthetics</topic><topic>Male</topic><topic>Mepivacaine - administration & dosage</topic><topic>Mepivacaine - toxicity</topic><topic>Models, Animal</topic><topic>Movement - drug effects</topic><topic>Neurotoxicity</topic><topic>Neurotoxicity Syndromes</topic><topic>Osmolar Concentration</topic><topic>Pathology</topic><topic>Prilocaine - administration & dosage</topic><topic>Prilocaine - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Regional anesthesia</topic><topic>Sensory impairment</topic><topic>Sensory Thresholds - drug effects</topic><topic>Spinal Cord - drug effects</topic><topic>Spinal Cord - ultrastructure</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takenami, Tamie</creatorcontrib><creatorcontrib>Yagishita, Saburo</creatorcontrib><creatorcontrib>Nara, Yoshihiro</creatorcontrib><creatorcontrib>Hoka, Sumio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><jtitle>Regional anesthesia and pain medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takenami, Tamie</au><au>Yagishita, Saburo</au><au>Nara, Yoshihiro</au><au>Hoka, Sumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model</atitle><jtitle>Regional anesthesia and pain medicine</jtitle><addtitle>Reg Anesth Pain Med</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>29</volume><issue>5</issue><spage>446</spage><epage>453</epage><pages>446-453</pages><issn>1098-7339</issn><eissn>1532-8651</eissn><abstract>Histologic evidence of the comparative neurotoxicity of lidocaine, mepivacaine, and prilocaine is incomplete. We compared the intrathecal neurotoxicity in rats among these 3 drugs based on morphologic and neurofunctional findings.
Rats (n = 169) randomly received 0.12 μL/g of 0%, 2%, 5%, 7.5%, 10%, or 20% lidocaine, mepivacaine, or prilocaine or 25% glucose dissolved in distilled water via a chronically implanted intrathecal catheter. The effect of the agents on neurofunction was evaluated by movement of the hind limb (behavior test) and by sensory threshold (paw-stimulation test). The L1 spinal cord, the posterior and anterior roots, and the cauda equina were removed en bloc 5 days later and examined by light and electron microscopy.
A significant decrease in sensory threshold or irreversible hind-limb limitation was observed only in rats receiving 20% lidocaine. Morphologic abnormalities characterized by axonal degeneration were observed in rats receiving ≥7.5% lidocaine, 20% mepivacaine, and 20% prilocaine, at the posterior white matter and the proximal portion of the posterior root just at the entrance into the spinal cord. The incidence of lesions was significantly higher in rats receiving lidocaine than mepivacaine and prilocaine.
It is suggested that intrathecal mepivacaine and prilocaine are less neurotoxic than highly concentrated lidocaine in a rat intrathecal model.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>15372390</pmid><doi>10.1016/j.rapm.2004.06.013</doi><tpages>8</tpages></addata></record> |
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| ispartof | Regional anesthesia and pain medicine, 2004-09, Vol.29 (5), p.446-453 |
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| subjects | Anesthetics, Local - administration & dosage Anesthetics, Local - toxicity Animals Behavior, Animal - drug effects Dose-Response Relationship, Drug Hydrogen-Ion Concentration Injections, Spinal - methods Lidocaine - administration & dosage Lidocaine - toxicity Local anesthetics Male Mepivacaine - administration & dosage Mepivacaine - toxicity Models, Animal Movement - drug effects Neurotoxicity Neurotoxicity Syndromes Osmolar Concentration Pathology Prilocaine - administration & dosage Prilocaine - toxicity Rats Rats, Wistar Regional anesthesia Sensory impairment Sensory Thresholds - drug effects Spinal Cord - drug effects Spinal Cord - ultrastructure Time Factors |
| title | Intrathecal mepivacaine and prilocaine are less neurotoxic than lidocaine in a rat intrathecal model |
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