Potentiation of the cardiac L-type Ca2+ channel (alpha1C) by dihydropyridine agonist and strong deplolarization occur via distinct mechanisms

Potentiation of the cardiac L-type Ca2+ channel (alpha1C) by dihydropyridine agonist and strong deplolarization occur via distinct mechanisms

A defining property of L-type Ca2+ channels is their potentiation by both 1,4-dihydropyridine agonists and strong depolarization. In contrast, non-L-type channels are potentiated by neither agonist nor depolarization, suggesting that these two processes may be linked.

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Bibliographische Detailangaben
Veröffentlicht in:The Journal of general physiology 2001-11, Vol.118 (5), p.495
Hauptverfasser: Wilkens, Christina M, Grabner, Manfred, Beam, Kurt G
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Calcium
Heart
Ions
Membranes
Muscular system
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Zusammenfassung:A defining property of L-type Ca2+ channels is their potentiation by both 1,4-dihydropyridine agonists and strong depolarization. In contrast, non-L-type channels are potentiated by neither agonist nor depolarization, suggesting that these two processes may be linked.
ISSN:0022-1295
1540-7748