(E)-Nicotinaldehyde O-Cinnamyloxime, a Nicotine Analog, Attenuates Neuronal Cells Death Against Rotenone-Induced Neurotoxicity

Parkinson’s disease (PD) is a neurodegenerative pathology characterized by resting tremor, rigidity, bradykinesia, and loss of dopamine-producing neurons in the pars compacta of the substantia nigra in the central nervous system (CNS) that result in dopamine depletion in the striatum. Oxidative stre...

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Veröffentlicht in:	Molecular neurobiology 2019-02, Vol.56 (2), p.1221-1232
Hauptverfasser:	Jurado-Coronel, Juan Camilo, Loaiza, Alix E., Díaz, John E., Cabezas, Ricardo, Ashraf, Ghulam Md, Sahebkar, Amirhossein, Echeverria, Valentina, González, Janneth, Barreto, George E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (nicotinic) Biomedical and Life Sciences Biomedicine Brain injury Cell Biology Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects Central nervous system Computational neuroscience Dopamine Epidemiology Humans Movement disorders Neostriatum Neurobiology Neurodegenerative diseases Neurology Neurons - drug effects Neurons - metabolism Neuroprotective Agents - pharmacology Neurosciences Neurotoxicity Nicotine Nicotine - analogs & derivatives Nicotine - pharmacology Oxidative stress Oxidative Stress - drug effects Parkinson Disease, Secondary - drug therapy Parkinson Disease, Secondary - metabolism Parkinson's disease Reactive oxygen species Reactive Oxygen Species - metabolism Rigidity Rotenone Rotenone - pharmacology Substantia nigra Tremor
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