Preparation and biological efficacy of haddock bone calcium tablets
To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone calcium powder by NaOH and ethanol soaking （alkalinealeohol method） and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The...
Gespeichert in:
| Veröffentlicht in: | Chinese journal of oceanology and limnology 2010-03, Vol.28 (2), p.371-378 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 378 |
|---|---|
| container_issue | 2 |
| container_start_page | 371 |
| container_title | Chinese journal of oceanology and limnology |
| container_volume | 28 |
| creator | Huo, Jiancong Deng, Shanggui Xie, Chao Tong, Guozhong |
| description | To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone calcium powder by NaOH and ethanol soaking （alkalinealeohol method） and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are： NaOH concentration 1 mol/L, immersion time 30 h; ethanol concentration 60%, immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol was used as an excipient at a ratio of 1：2 to full-cream milk powder, without the use of a disintegrating agent. This process provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets at a dose of 2 g·kg^-1·d^-1 or 5g·kg^-1·d^-1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore, these tablets could be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with haddock bone calcium tablets are unclear, it is suggested that there are some factors, such as treatment with method of alkaline-alcohol or the added milk, may play positive roles in increasing absorption ratio. |
| doi_str_mv | 10.1007/s00343-010-9019-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_204989411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>36080728</cqvip_id><sourcerecordid>1990642361</sourcerecordid><originalsourceid>FETCH-LOGICAL-c342t-37f15b5a8c3bc0a7a5f175ca8528a323ce46e3287cf3cce5fef9364e37fe7df83</originalsourceid><addsrcrecordid>eNp9kLtOAzEQRS0EEiHwAXQWvWH8ytolinhJkaCA2vJ67WSTzTqxN0X-HkcbiY5qirnnzuggdE_hkQJUTxmAC06AAtFANYELNKFacyIB5CWaAJOCCJD6Gt3kvC5pLUBP0Pwr-Z1Ndmhjj23f4LqNXVy2znbYh1CmO-IY8Mo2TXQbXMfe47J07WGLB1t3fsi36CrYLvu785yin9eX7_k7WXy-fcyfF8RxwQbCq0BlLa1yvHZgKysDraSzSjJlOePOi5nnTFUucOe8DD5oPhO-cL5qguJT9DD27lLcH3wezDoeUl9OGgZCKy0oLSE6hlyKOScfzC61W5uOhoI5qTKjKlNUmZMqA4VhI5NLtl_69Ff8H3T-xq1iv9wXztTWbULbecNnoKBiiv8Cldp3IA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>204989411</pqid></control><display><type>article</type><title>Preparation and biological efficacy of haddock bone calcium tablets</title><source>ProQuest Central Essentials</source><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central Student</source><source>ProQuest Central Korea</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Huo, Jiancong ; Deng, Shanggui ; Xie, Chao ; Tong, Guozhong</creator><creatorcontrib>Huo, Jiancong ; Deng, Shanggui ; Xie, Chao ; Tong, Guozhong</creatorcontrib><description>To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone calcium powder by NaOH and ethanol soaking （alkalinealeohol method） and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are： NaOH concentration 1 mol/L, immersion time 30 h; ethanol concentration 60%, immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol was used as an excipient at a ratio of 1：2 to full-cream milk powder, without the use of a disintegrating agent. This process provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets at a dose of 2 g·kg^-1·d^-1 or 5g·kg^-1·d^-1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore, these tablets could be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with haddock bone calcium tablets are unclear, it is suggested that there are some factors, such as treatment with method of alkaline-alcohol or the added milk, may play positive roles in increasing absorption ratio.</description><identifier>ISSN: 0254-4059</identifier><identifier>ISSN: 2096-5508</identifier><identifier>EISSN: 1993-5005</identifier><identifier>EISSN: 2523-3521</identifier><identifier>DOI: 10.1007/s00343-010-9019-0</identifier><language>eng</language><publisher>Heidelberg: SP Science Press</publisher><subject>Absorption ; Alcohols ; Animal models ; Aquaculture ; Bones ; Calcium ; Calcium (blood) ; Disintegration ; Earth and Environmental Science ; Earth Sciences ; Effectiveness ; Ethanol ; Excipients ; Fish ; Gadinae ; Immersion ; Marine biology ; Marine fishes ; Milk ; Oceanography ; Osteoporosis ; Phosphorus ; Physics ; Polyvinylpyrrolidone ; Powder ; Rigidity ; Sodium hydroxide ; Submerging ; Tablets ; 乙醇浓度 ; 浸泡时间 ; 生物有效性 ; 聚乙烯吡咯烷酮 ; 骨质疏松症</subject><ispartof>Chinese journal of oceanology and limnology, 2010-03, Vol.28 (2), p.371-378</ispartof><rights>Chinese Society for Oceanology and Limnology, Science Press and Springer Berlin Heidelberg 2010</rights><rights>Chinese Society for Oceanology and Limnology, Science Press and Springer Berlin Heidelberg 2010.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-37f15b5a8c3bc0a7a5f175ca8528a323ce46e3287cf3cce5fef9364e37fe7df83</citedby><cites>FETCH-LOGICAL-c342t-37f15b5a8c3bc0a7a5f175ca8528a323ce46e3287cf3cce5fef9364e37fe7df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84119X/84119X.jpg</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/204989411/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/204989411?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21388,21389,21390,21391,23256,27924,27925,33530,33703,33744,34005,34314,43659,43787,43805,43953,44067,64385,64389,72469,74104,74283,74302,74473,74590</link.rule.ids></links><search><creatorcontrib>Huo, Jiancong</creatorcontrib><creatorcontrib>Deng, Shanggui</creatorcontrib><creatorcontrib>Xie, Chao</creatorcontrib><creatorcontrib>Tong, Guozhong</creatorcontrib><title>Preparation and biological efficacy of haddock bone calcium tablets</title><title>Chinese journal of oceanology and limnology</title><addtitle>Chin. J. Ocean. Limnol</addtitle><addtitle>Chinese Journal of Oceanology and Limnology</addtitle><description>To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone calcium powder by NaOH and ethanol soaking （alkalinealeohol method） and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are： NaOH concentration 1 mol/L, immersion time 30 h; ethanol concentration 60%, immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol was used as an excipient at a ratio of 1：2 to full-cream milk powder, without the use of a disintegrating agent. This process provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets at a dose of 2 g·kg^-1·d^-1 or 5g·kg^-1·d^-1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore, these tablets could be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with haddock bone calcium tablets are unclear, it is suggested that there are some factors, such as treatment with method of alkaline-alcohol or the added milk, may play positive roles in increasing absorption ratio.</description><subject>Absorption</subject><subject>Alcohols</subject><subject>Animal models</subject><subject>Aquaculture</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium (blood)</subject><subject>Disintegration</subject><subject>Earth and Environmental Science</subject><subject>Earth Sciences</subject><subject>Effectiveness</subject><subject>Ethanol</subject><subject>Excipients</subject><subject>Fish</subject><subject>Gadinae</subject><subject>Immersion</subject><subject>Marine biology</subject><subject>Marine fishes</subject><subject>Milk</subject><subject>Oceanography</subject><subject>Osteoporosis</subject><subject>Phosphorus</subject><subject>Physics</subject><subject>Polyvinylpyrrolidone</subject><subject>Powder</subject><subject>Rigidity</subject><subject>Sodium hydroxide</subject><subject>Submerging</subject><subject>Tablets</subject><subject>乙醇浓度</subject><subject>浸泡时间</subject><subject>生物有效性</subject><subject>聚乙烯吡咯烷酮</subject><subject>骨质疏松症</subject><issn>0254-4059</issn><issn>2096-5508</issn><issn>1993-5005</issn><issn>2523-3521</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kLtOAzEQRS0EEiHwAXQWvWH8ytolinhJkaCA2vJ67WSTzTqxN0X-HkcbiY5qirnnzuggdE_hkQJUTxmAC06AAtFANYELNKFacyIB5CWaAJOCCJD6Gt3kvC5pLUBP0Pwr-Z1Ndmhjj23f4LqNXVy2znbYh1CmO-IY8Mo2TXQbXMfe47J07WGLB1t3fsi36CrYLvu785yin9eX7_k7WXy-fcyfF8RxwQbCq0BlLa1yvHZgKysDraSzSjJlOePOi5nnTFUucOe8DD5oPhO-cL5qguJT9DD27lLcH3wezDoeUl9OGgZCKy0oLSE6hlyKOScfzC61W5uOhoI5qTKjKlNUmZMqA4VhI5NLtl_69Ff8H3T-xq1iv9wXztTWbULbecNnoKBiiv8Cldp3IA</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Huo, Jiancong</creator><creator>Deng, Shanggui</creator><creator>Xie, Chao</creator><creator>Tong, Guozhong</creator><general>SP Science Press</general><general>Springer Nature B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W95</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QL</scope><scope>7SN</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7XB</scope><scope>88I</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>GNUQQ</scope><scope>H96</scope><scope>HCIFZ</scope><scope>L.G</scope><scope>M2P</scope><scope>M7N</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20100301</creationdate><title>Preparation and biological efficacy of haddock bone calcium tablets</title><author>Huo, Jiancong ; Deng, Shanggui ; Xie, Chao ; Tong, Guozhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-37f15b5a8c3bc0a7a5f175ca8528a323ce46e3287cf3cce5fef9364e37fe7df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorption</topic><topic>Alcohols</topic><topic>Animal models</topic><topic>Aquaculture</topic><topic>Bones</topic><topic>Calcium</topic><topic>Calcium (blood)</topic><topic>Disintegration</topic><topic>Earth and Environmental Science</topic><topic>Earth Sciences</topic><topic>Effectiveness</topic><topic>Ethanol</topic><topic>Excipients</topic><topic>Fish</topic><topic>Gadinae</topic><topic>Immersion</topic><topic>Marine biology</topic><topic>Marine fishes</topic><topic>Milk</topic><topic>Oceanography</topic><topic>Osteoporosis</topic><topic>Phosphorus</topic><topic>Physics</topic><topic>Polyvinylpyrrolidone</topic><topic>Powder</topic><topic>Rigidity</topic><topic>Sodium hydroxide</topic><topic>Submerging</topic><topic>Tablets</topic><topic>乙醇浓度</topic><topic>浸泡时间</topic><topic>生物有效性</topic><topic>聚乙烯吡咯烷酮</topic><topic>骨质疏松症</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, Jiancong</creatorcontrib><creatorcontrib>Deng, Shanggui</creatorcontrib><creatorcontrib>Xie, Chao</creatorcontrib><creatorcontrib>Tong, Guozhong</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-农业科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 2: Ocean Technology, Policy & Non-Living Resources</collection><collection>SciTech Premium Collection</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Chinese journal of oceanology and limnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, Jiancong</au><au>Deng, Shanggui</au><au>Xie, Chao</au><au>Tong, Guozhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and biological efficacy of haddock bone calcium tablets</atitle><jtitle>Chinese journal of oceanology and limnology</jtitle><stitle>Chin. J. Ocean. Limnol</stitle><addtitle>Chinese Journal of Oceanology and Limnology</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>28</volume><issue>2</issue><spage>371</spage><epage>378</epage><pages>371-378</pages><issn>0254-4059</issn><issn>2096-5508</issn><eissn>1993-5005</eissn><eissn>2523-3521</eissn><abstract>To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone calcium powder by NaOH and ethanol soaking （alkalinealeohol method） and prepared haddock bone calcium tablets using the powder in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are： NaOH concentration 1 mol/L, immersion time 30 h; ethanol concentration 60%, immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol was used as an excipient at a ratio of 1：2 to full-cream milk powder, without the use of a disintegrating agent. This process provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets at a dose of 2 g·kg^-1·d^-1 or 5g·kg^-1·d^-1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore, these tablets could be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with haddock bone calcium tablets are unclear, it is suggested that there are some factors, such as treatment with method of alkaline-alcohol or the added milk, may play positive roles in increasing absorption ratio.</abstract><cop>Heidelberg</cop><pub>SP Science Press</pub><doi>10.1007/s00343-010-9019-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0254-4059 |
| ispartof | Chinese journal of oceanology and limnology, 2010-03, Vol.28 (2), p.371-378 |
| issn | 0254-4059 2096-5508 1993-5005 2523-3521 |
| language | eng |
| recordid | cdi_proquest_journals_204989411 |
| source | ProQuest Central Essentials; ProQuest Central (Alumni Edition); ProQuest Central Student; ProQuest Central Korea; ProQuest Central UK/Ireland; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Absorption Alcohols Animal models Aquaculture Bones Calcium Calcium (blood) Disintegration Earth and Environmental Science Earth Sciences Effectiveness Ethanol Excipients Fish Gadinae Immersion Marine biology Marine fishes Milk Oceanography Osteoporosis Phosphorus Physics Polyvinylpyrrolidone Powder Rigidity Sodium hydroxide Submerging Tablets 乙醇浓度 浸泡时间 生物有效性 聚乙烯吡咯烷酮 骨质疏松症 |
| title | Preparation and biological efficacy of haddock bone calcium tablets |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T04%3A47%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preparation%20and%20biological%20efficacy%20of%20haddock%20bone%20calcium%20tablets&rft.jtitle=Chinese%20journal%20of%20oceanology%20and%20limnology&rft.au=Huo,%20Jiancong&rft.date=2010-03-01&rft.volume=28&rft.issue=2&rft.spage=371&rft.epage=378&rft.pages=371-378&rft.issn=0254-4059&rft.eissn=1993-5005&rft_id=info:doi/10.1007/s00343-010-9019-0&rft_dat=%3Cproquest_cross%3E1990642361%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=204989411&rft_id=info:pmid/&rft_cqvip_id=36080728&rfr_iscdi=true |