Overexpression of ZAKβ in human osteosarcoma cells enhances ZAKα expression, resulting in a synergistic apoptotic effect

ZAK is a novel mixed lineage kinase‐like protein that contains a leucine‐zipper and a sterile‐alpha motif as a protein‐protein interaction domain, and it is located in the cytoplasm. There are 2 alternatively spliced forms of ZAK: ZAKα and ZAKβ. Previous studies showed that ZAKα is involved in vario...

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Veröffentlicht in:	Cell biochemistry and function 2018-06, Vol.36 (4), p.176-182
Hauptverfasser:	Fu, Chien‐Yao, Tseng, Yan‐Shen, Chen, Ming‐Cheng, Hsu, Hsi‐Hsien, Yang, Jaw‐Ji, Tu, Chuan‐Chou, Lin, Yueh‐Min, Viswanadha, Vijaya Padma, Ding, Ke, Kuo, Wei‐Wen, Huang, Chih‐Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Antibiotics, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects apoptotic effect Biocompatibility Bone cancer Cell differentiation Cell proliferation Cell Survival - drug effects Cytoplasm Differentiation (biology) Dose-Response Relationship, Drug Doxorubicin - pharmacology Drug Synergism Eutrophication Heart diseases Humans Hypertrophy Immunoprecipitation Kinases Leucine Leucine zipper proteins MAP kinase MAP Kinase Kinase Kinases Molecular chains Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma cells Protein Kinases - biosynthesis Proteins sterile‐alpha motif Structure-Activity Relationship Tumor Cells, Cultured Tumorigenesis ZAKα ZAKβ
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