Attenuating effects of caffeic acid phenethyl ester and betaine on abamectin-induced hepatotoxicity and nephrotoxicity

Abamectin (ABM) is a widely utilized potent anthelmintic and insecticidal agent. In this study, we investigated the protective effects of caffeic acid phenethyl ester (CAPE) and betaine (BET) against ABM-induced hepatotoxicity and nephrotoxicity in rats. Forty rats were divided into five groups, rec...

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Veröffentlicht in:	Environmental science and pollution research international 2018-06, Vol.25 (16), p.15909-15917
Hauptverfasser:	Abdel-Daim, Mohamed M., Abdellatief, Suhair A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abamectin Alkaline phosphatase Animals Anthelmintic agents Antioxidants Antioxidants - pharmacology Antiparasitic agents Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Betaine Betaine - pharmacology Biochemical analysis Caffeic acid Caffeic Acids - pharmacology Catalase Catalase - metabolism Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Chemoprotection Cholesterol Creatinine Creatinine - blood Creatinine - chemistry Dietary supplements Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Enzymatic activity Fungicides Glutathione Glutathione - chemistry Glutathione - pharmacology Glutathione peroxidase Glutathione Peroxidase - chemistry Hepatotoxicity Inflammation Insecticides Ivermectin - analogs & derivatives Ivermectin - chemistry Ivermectin - metabolism Ivermectin - toxicity Kidney - cytology Kidney - drug effects Kidney - pathology Kidneys L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Liver Male Malondialdehyde Malondialdehyde - chemistry Malondialdehyde - pharmacology Molecular chains Nitric oxide Nitric Oxide - chemistry Nitric Oxide - metabolism Oxidative stress Peroxidase Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - pharmacology Pretreatment Rats Rats, Wistar Research Article Rodents Saline solutions Serum levels Superoxide dismutase Superoxide Dismutase - chemistry Superoxide Dismutase - metabolism Urea Waste Water Technology Water Management Water Pollution Control
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Zusammenfassung:	Abamectin (ABM) is a widely utilized potent anthelmintic and insecticidal agent. In this study, we investigated the protective effects of caffeic acid phenethyl ester (CAPE) and betaine (BET) against ABM-induced hepatotoxicity and nephrotoxicity in rats. Forty rats were divided into five groups, receiving either oral saline solution (normal control), oral ABM at a dose of 2 mg/kg BW (1/5 LD50), CAPE (10 μmol/kg BW intraperitoneally) followed by ABM, or BET supplementation at a dose of 250 mg/kg BW followed by ABM administration, while group V rats received a combination of i.p. CAPE and oral BET in the same doses before receiving ABM. Biochemical analysis showed that ABM administration significantly ( p
ISSN:	0944-1344 1614-7499
DOI:	10.1007/s11356-018-1786-8