Methotrexate Induced Lung Toxicity-A Case Report

[1] In patients with medication-induced lung toxicity, the radiologic patterns are highly variable and it rely upon the sort of antagonistic response the patient is experiencing. Since the vast majority of the medication prompted lung toxicities like the interstitial infiltrates, parenchyma may might be exhibited on radiographs. [3] Major criteria are as follows: * Hypersensitivity pneumonitis in view of histopathology, without confirmation of pathogenic organisms * Radiologic evidence of alveolar or pulmonary interstitial infiltrates. * Negative blood cultures (if febrile) and initial sputum cultures (if sputum is produced) Minor criteria are as follows: * Cough that are non-productive * Shortness of breath for < 2 months * During initial evaluation, Oxygen saturation < 90% on room air. * DLCO < 70% of predicted * < 15,000 cells/pL of leukocyte count There are very few studies in similar occurrence. In this case study, patient showed better clinical presentation after the cessation of the culprit, high dose methotrexate, Prompt diagnosis is vital in cases like above, in light of the fact that early medication-induced lung damage will frequently relapse with the end of treatment. Acute pneumonitis associated with low dose methotrexate treatment for rheumatoid arthritis: report of five cases and review of published reports: