MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3
MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA‐22 (miR‐22) has been reported to be a cancer‐related miRNA in several types of tumors. In this study, we aimed to investigate the role of miR‐22 in oral squamous cell carcinoma...
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| Veröffentlicht in: | Journal of cellular physiology 2018-09, Vol.233 (9), p.6705-6713 |
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| creator | Feng, Xiaodong Luo, Qingqiong Wang, Han Zhang, Han Chen, Fuxiang |
| description | MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA‐22 (miR‐22) has been reported to be a cancer‐related miRNA in several types of tumors. In this study, we aimed to investigate the role of miR‐22 in oral squamous cell carcinoma (OSCC). We found that miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. Furthermore, lentivirus‐mediated miR‐22 overexpression markedly reduced OSCC cell viability, migration and invasion, whereas miR‐22 inhibitor promoted these parameters. Mechanistically, NLR family pyrin domain containing three (NLRP3) was identified as a direct target of miR‐22. miR‐22 expression was inversely correlated with NLRP3 expression both in OSCC tissues and cell lines. Moreover, overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus. Therefore, our results indicate that miR‐22 may play a suppressive role in OSCC by targeting NLRP3, which offer new insights into the molecular mechanisms of the growth and metastasis of OSCC.
miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. NLR family pyrin domain containing 3 (NLRP3) was identified as a direct target of miR‐22. Overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus. |
| doi_str_mv | 10.1002/jcp.26331 |
| format | Article |
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miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. NLR family pyrin domain containing 3 (NLRP3) was identified as a direct target of miR‐22. Overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.26331</identifier><identifier>PMID: 29319163</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Carcinogenesis ; Carcinogens ; Cell migration ; Cell proliferation ; Inflammasomes ; Metastases ; MicroRNAs ; migration and invasion ; miRNA ; miR‐22 ; Molecular chains ; Molecular modelling ; NLRP3 ; Oral cancer ; Oral squamous cell carcinoma ; Parameter identification ; Pyrin protein ; Regulators ; Ribonucleic acid ; RNA ; Squamous cell carcinoma ; Target recognition ; Tumors</subject><ispartof>Journal of cellular physiology, 2018-09, Vol.233 (9), p.6705-6713</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>This article is protected by copyright. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4191-f6effaa56bd33309c61deb89ac42e0c9dbecc0f0360e6b0dbf26a68c4a9f334c3</citedby><cites>FETCH-LOGICAL-c4191-f6effaa56bd33309c61deb89ac42e0c9dbecc0f0360e6b0dbf26a68c4a9f334c3</cites><orcidid>0000-0002-4093-2676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.26331$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.26331$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29319163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Xiaodong</creatorcontrib><creatorcontrib>Luo, Qingqiong</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Chen, Fuxiang</creatorcontrib><title>MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA‐22 (miR‐22) has been reported to be a cancer‐related miRNA in several types of tumors. In this study, we aimed to investigate the role of miR‐22 in oral squamous cell carcinoma (OSCC). We found that miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. Furthermore, lentivirus‐mediated miR‐22 overexpression markedly reduced OSCC cell viability, migration and invasion, whereas miR‐22 inhibitor promoted these parameters. Mechanistically, NLR family pyrin domain containing three (NLRP3) was identified as a direct target of miR‐22. miR‐22 expression was inversely correlated with NLRP3 expression both in OSCC tissues and cell lines. Moreover, overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus. Therefore, our results indicate that miR‐22 may play a suppressive role in OSCC by targeting NLRP3, which offer new insights into the molecular mechanisms of the growth and metastasis of OSCC.
miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. NLR family pyrin domain containing 3 (NLRP3) was identified as a direct target of miR‐22. Overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus.</description><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell migration</subject><subject>Cell proliferation</subject><subject>Inflammasomes</subject><subject>Metastases</subject><subject>MicroRNAs</subject><subject>migration and invasion</subject><subject>miRNA</subject><subject>miR‐22</subject><subject>Molecular chains</subject><subject>Molecular modelling</subject><subject>NLRP3</subject><subject>Oral cancer</subject><subject>Oral squamous cell carcinoma</subject><subject>Parameter identification</subject><subject>Pyrin protein</subject><subject>Regulators</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Squamous cell carcinoma</subject><subject>Target recognition</subject><subject>Tumors</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOAyEUhonR2HpZ-AKGxJWJUw8wpbI0jdfUaoyuCcNAQzM3YUbTnY_gM_okolPduTqc8PGfw4fQAYERAaCnS92MKGeMbKAhATFJUj6mm2gY70gixikZoJ0QlgAgBGPbaEAFI4JwNkSvd077-nF-_vn-QSkOXdN4E4IJWJuiwI2vC2eNV62rqxNcukV_xKrKsateVfhuXIVrrwocXjpV1t36rVZeu6ouFc5WuFV-YVpXLfB89vjA9tCWVUUw--u6i54vL56m18ns_upmej5LdBoXTCw31io15lnOGAOhOclNdiaUTqkBLfLMaA0WGAfDM8gzS7niZzpVwjKWaraLjvrc-JGXzoRWLuvOV3GkpJBOUgaEQqSOeyqqCMEbKxvvSuVXkoD8NiyjYfljOLKH68QuK03-R_4qjcBpD7y5wqz-T5K304c-8gu7qYeb</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Feng, Xiaodong</creator><creator>Luo, Qingqiong</creator><creator>Wang, Han</creator><creator>Zhang, Han</creator><creator>Chen, Fuxiang</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-4093-2676</orcidid></search><sort><creationdate>201809</creationdate><title>MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3</title><author>Feng, Xiaodong ; Luo, Qingqiong ; Wang, Han ; Zhang, Han ; Chen, Fuxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4191-f6effaa56bd33309c61deb89ac42e0c9dbecc0f0360e6b0dbf26a68c4a9f334c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cell migration</topic><topic>Cell proliferation</topic><topic>Inflammasomes</topic><topic>Metastases</topic><topic>MicroRNAs</topic><topic>migration and invasion</topic><topic>miRNA</topic><topic>miR‐22</topic><topic>Molecular chains</topic><topic>Molecular modelling</topic><topic>NLRP3</topic><topic>Oral cancer</topic><topic>Oral squamous cell carcinoma</topic><topic>Parameter identification</topic><topic>Pyrin protein</topic><topic>Regulators</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Squamous cell carcinoma</topic><topic>Target recognition</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Xiaodong</creatorcontrib><creatorcontrib>Luo, Qingqiong</creatorcontrib><creatorcontrib>Wang, Han</creatorcontrib><creatorcontrib>Zhang, Han</creatorcontrib><creatorcontrib>Chen, Fuxiang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Xiaodong</au><au>Luo, Qingqiong</au><au>Wang, Han</au><au>Zhang, Han</au><au>Chen, Fuxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2018-09</date><risdate>2018</risdate><volume>233</volume><issue>9</issue><spage>6705</spage><epage>6713</epage><pages>6705-6713</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>MicroRNAs (miRNAs) have been implicated as important regulators of carcinogenesis and tumor development. Recently, microRNA‐22 (miR‐22) has been reported to be a cancer‐related miRNA in several types of tumors. In this study, we aimed to investigate the role of miR‐22 in oral squamous cell carcinoma (OSCC). We found that miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. Furthermore, lentivirus‐mediated miR‐22 overexpression markedly reduced OSCC cell viability, migration and invasion, whereas miR‐22 inhibitor promoted these parameters. Mechanistically, NLR family pyrin domain containing three (NLRP3) was identified as a direct target of miR‐22. miR‐22 expression was inversely correlated with NLRP3 expression both in OSCC tissues and cell lines. Moreover, overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus. Therefore, our results indicate that miR‐22 may play a suppressive role in OSCC by targeting NLRP3, which offer new insights into the molecular mechanisms of the growth and metastasis of OSCC.
miR‐22 expression was significantly decreased in OSCC tissues compared with that in the adjacent noncancerous tissues. NLR family pyrin domain containing 3 (NLRP3) was identified as a direct target of miR‐22. Overexpression of miR‐22 in OSCC cells could reverse the tumor‐promoting effect of the activated NLRP3 inflammasome and vice versus.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29319163</pmid><doi>10.1002/jcp.26331</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4093-2676</orcidid></addata></record> |
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| subjects | Carcinogenesis Carcinogens Cell migration Cell proliferation Inflammasomes Metastases MicroRNAs migration and invasion miRNA miR‐22 Molecular chains Molecular modelling NLRP3 Oral cancer Oral squamous cell carcinoma Parameter identification Pyrin protein Regulators Ribonucleic acid RNA Squamous cell carcinoma Target recognition Tumors |
| title | MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3 |
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