Embryo–fetal toxicity assessment of vonoprazan in rats and rabbits

Vonoprazan is a new potassium‐competitive acid blocker to treat acid‐related diseases. However, its safety during pregnancy is unclear. The aim of the study was to investigate the potential reproductive toxicity on the embryo–fetal development of vonoprazan. Vonoprazan acetate was administered by in...

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Veröffentlicht in:	Journal of applied toxicology 2018-07, Vol.38 (7), p.987-995
Hauptverfasser:	Li, Tianyi, Qiao, Hongqun, Yue, Peng, Cai, Ming, He, Xuejun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid embryo–fetal development Exposure Fetuses Gestation Growth rate Intravenous administration Ossification Placenta Potassium Pregnancy Rabbits Rats reproductive toxicity Rodents Toxicity vonoprazan
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