Impact of ABO‐mismatch on outcome in bone marrow transplantation

Impact of ABO‐mismatch on outcome in bone marrow transplantation

Background ABO‐mismatch between donor and recipient of bone marrow transplantation (BMT) can impact clinical outcome. This is a retrospective single‐centre study that aimed to compare overall survival, transfusion requirements, time of neutrophil engraftment and the incidence of veno‐occlusive disea...

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Veröffentlicht in:ISBT science series 2018-05, Vol.13 (2), p.158-164
Hauptverfasser: De Santis, G. C., Malta, R. O., Garcia‐Silva, A. C., Prata, K. de L., Oliveira, M. C., Moraes, D. A., Stracieri, A. B. P., Pieroni, F., Martinez, E. Z., Simões, B. P., Covas, D. T.
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ABO blood group
blood transfusion
Bone marrow
haematopoietic cell transplantation
Neutrophils
Stem cell transplantation
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container_end_page 164
container_issue 2
container_start_page 158
container_title ISBT science series
container_volume 13
creator De Santis, G. C.
Malta, R. O.
Garcia‐Silva, A. C.
Prata, K. de L.
Oliveira, M. C.
Moraes, D. A.
Stracieri, A. B. P.
Pieroni, F.
Martinez, E. Z.
Simões, B. P.
Covas, D. T.
description Background ABO‐mismatch between donor and recipient of bone marrow transplantation (BMT) can impact clinical outcome. This is a retrospective single‐centre study that aimed to compare overall survival, transfusion requirements, time of neutrophil engraftment and the incidence of veno‐occlusive disease (VOD) and graft‐vs‐host disease (GVHD) in recipients of BMT with ABO‐match and mismatch. Methods We reviewed the charts of 140 recipients of related HLA full‐match BMT, between 1998 and 2014. We found 39 cases of ABO‐mismatch (27·9%), of which 21 (53·8%) with major, 14 (35·9%) with minor and 4 (10·3%) with bidirectional mismatch. Results ABO‐mismatch had no impact on survival, neutrophil engraftment and the incidence of VOD and acute GVHD. Minor mismatch patients had higher risk for chronic GVHD than major mismatch (P = 0·02). Median transfusions of red blood cell (RBC) units were 5 (0–57) and 10 (1–47) for match and mismatch groups (P = 0·004), and 12 (2–47) for major mismatch (P = 0·005). Median transfusions of platelet units were 46 (0–756) and 73 (0–429) for match and mismatch groups (P = 0·06). Conclusion ABO‐mismatch seems to be less frequent in Brazil. ABO‐mismatch had no significant impact on survival, neutrophil engraftment and VOD, but resulted in increased transfusion of RBC.
doi_str_mv 10.1111/voxs.12371
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C. ; Malta, R. O. ; Garcia‐Silva, A. C. ; Prata, K. de L. ; Oliveira, M. C. ; Moraes, D. A. ; Stracieri, A. B. P. ; Pieroni, F. ; Martinez, E. Z. ; Simões, B. P. ; Covas, D. T.</creator><creatorcontrib>De Santis, G. C. ; Malta, R. O. ; Garcia‐Silva, A. C. ; Prata, K. de L. ; Oliveira, M. C. ; Moraes, D. A. ; Stracieri, A. B. P. ; Pieroni, F. ; Martinez, E. Z. ; Simões, B. P. ; Covas, D. T.</creatorcontrib><description>Background ABO‐mismatch between donor and recipient of bone marrow transplantation (BMT) can impact clinical outcome. This is a retrospective single‐centre study that aimed to compare overall survival, transfusion requirements, time of neutrophil engraftment and the incidence of veno‐occlusive disease (VOD) and graft‐vs‐host disease (GVHD) in recipients of BMT with ABO‐match and mismatch. Methods We reviewed the charts of 140 recipients of related HLA full‐match BMT, between 1998 and 2014. We found 39 cases of ABO‐mismatch (27·9%), of which 21 (53·8%) with major, 14 (35·9%) with minor and 4 (10·3%) with bidirectional mismatch. Results ABO‐mismatch had no impact on survival, neutrophil engraftment and the incidence of VOD and acute GVHD. Minor mismatch patients had higher risk for chronic GVHD than major mismatch (P = 0·02). Median transfusions of red blood cell (RBC) units were 5 (0–57) and 10 (1–47) for match and mismatch groups (P = 0·004), and 12 (2–47) for major mismatch (P = 0·005). Median transfusions of platelet units were 46 (0–756) and 73 (0–429) for match and mismatch groups (P = 0·06). Conclusion ABO‐mismatch seems to be less frequent in Brazil. ABO‐mismatch had no significant impact on survival, neutrophil engraftment and VOD, but resulted in increased transfusion of RBC.</description><identifier>ISSN: 1751-2816</identifier><identifier>EISSN: 1751-2824</identifier><identifier>DOI: 10.1111/voxs.12371</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>ABO blood group ; blood transfusion ; Bone marrow ; haematopoietic cell transplantation ; Neutrophils ; Stem cell transplantation</subject><ispartof>ISBT science series, 2018-05, Vol.13 (2), p.158-164</ispartof><rights>2017 International Society of Blood Transfusion</rights><rights>Copyright ISBT Science Series © 2018 International Society of Blood Transfusion</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1051-1a9287dbcfe2a60031ab64bb412cafa42db4bfa9ee82227761fad3a1e24aeb983</cites><orcidid>0000-0003-0873-1206</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fvoxs.12371$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fvoxs.12371$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>De Santis, G. 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This is a retrospective single‐centre study that aimed to compare overall survival, transfusion requirements, time of neutrophil engraftment and the incidence of veno‐occlusive disease (VOD) and graft‐vs‐host disease (GVHD) in recipients of BMT with ABO‐match and mismatch. Methods We reviewed the charts of 140 recipients of related HLA full‐match BMT, between 1998 and 2014. We found 39 cases of ABO‐mismatch (27·9%), of which 21 (53·8%) with major, 14 (35·9%) with minor and 4 (10·3%) with bidirectional mismatch. Results ABO‐mismatch had no impact on survival, neutrophil engraftment and the incidence of VOD and acute GVHD. Minor mismatch patients had higher risk for chronic GVHD than major mismatch (P = 0·02). Median transfusions of red blood cell (RBC) units were 5 (0–57) and 10 (1–47) for match and mismatch groups (P = 0·004), and 12 (2–47) for major mismatch (P = 0·005). Median transfusions of platelet units were 46 (0–756) and 73 (0–429) for match and mismatch groups (P = 0·06). 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Z.</creatorcontrib><creatorcontrib>Simões, B. P.</creatorcontrib><creatorcontrib>Covas, D. T.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>ISBT science series</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Santis, G. C.</au><au>Malta, R. O.</au><au>Garcia‐Silva, A. C.</au><au>Prata, K. de L.</au><au>Oliveira, M. C.</au><au>Moraes, D. A.</au><au>Stracieri, A. B. P.</au><au>Pieroni, F.</au><au>Martinez, E. Z.</au><au>Simões, B. P.</au><au>Covas, D. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of ABO‐mismatch on outcome in bone marrow transplantation</atitle><jtitle>ISBT science series</jtitle><date>2018-05</date><risdate>2018</risdate><volume>13</volume><issue>2</issue><spage>158</spage><epage>164</epage><pages>158-164</pages><issn>1751-2816</issn><eissn>1751-2824</eissn><abstract>Background ABO‐mismatch between donor and recipient of bone marrow transplantation (BMT) can impact clinical outcome. This is a retrospective single‐centre study that aimed to compare overall survival, transfusion requirements, time of neutrophil engraftment and the incidence of veno‐occlusive disease (VOD) and graft‐vs‐host disease (GVHD) in recipients of BMT with ABO‐match and mismatch. Methods We reviewed the charts of 140 recipients of related HLA full‐match BMT, between 1998 and 2014. We found 39 cases of ABO‐mismatch (27·9%), of which 21 (53·8%) with major, 14 (35·9%) with minor and 4 (10·3%) with bidirectional mismatch. Results ABO‐mismatch had no impact on survival, neutrophil engraftment and the incidence of VOD and acute GVHD. Minor mismatch patients had higher risk for chronic GVHD than major mismatch (P = 0·02). Median transfusions of red blood cell (RBC) units were 5 (0–57) and 10 (1–47) for match and mismatch groups (P = 0·004), and 12 (2–47) for major mismatch (P = 0·005). Median transfusions of platelet units were 46 (0–756) and 73 (0–429) for match and mismatch groups (P = 0·06). Conclusion ABO‐mismatch seems to be less frequent in Brazil. 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subjects ABO blood group
blood transfusion
Bone marrow
haematopoietic cell transplantation
Neutrophils
Stem cell transplantation
title Impact of ABO‐mismatch on outcome in bone marrow transplantation
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